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ASSY - Argininosuccinate synthase
UniProt: P0A6E4 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10068
Length: 447 (400)
Sequences: 1308
Seq/Len: 3.27

ASSY
Paralog alert: 0.03 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
240_R 248_A 6.133 1.00
268_G 299_L 4.989 1.00
235_E 271_H 4.943 1.00
119_K 148_N 4.421 1.00
263_E 266_R 4.209 1.00
252_K 263_E 4.183 1.00
235_E 270_R 3.841 1.00
357_T 379_N 3.807 1.00
235_E 250_N 3.493 1.00
238_T 359_E 3.376 1.00
86_Q 353_A 3.162 1.00
114_L 144_G 3.147 1.00
67_N 121_D 3.135 1.00
174_E 178_A 2.849 1.00
240_R 359_E 2.835 1.00
58_R 62_E 2.833 1.00
359_E 376_V 2.693 1.00
75_K 79_A 2.588 1.00
75_K 256_D 2.583 1.00
283_I 335_R 2.465 1.00
71_I 113_M 2.396 1.00
239_V 246_P 2.35 1.00
12_Q 124_N 2.345 1.00
236_E 363_E 2.336 1.00
84_A 105_L 2.306 1.00
44_N 74_R 2.301 1.00
114_L 126_W 2.263 1.00
33_Q 179_C 2.259 1.00
113_M 116_A 2.227 1.00
15_G 123_V 2.223 1.00
33_Q 175_F 2.215 1.00
78_V 261_M 2.195 1.00
126_W 144_G 2.15 1.00
241_F 300_L 2.112 1.00
69_R 120_E 2.08 1.00
119_K 150_E 2.048 1.00
345_R 349_Q 2.034 1.00
218_N 236_E 2.013 1.00
350_R 354_S 2.001 1.00
242_E 253_T 1.999 1.00
211_N 376_V 1.957 1.00
240_R 357_T 1.946 1.00
242_E 247_V 1.937 1.00
246_P 260_M 1.883 0.99
167_G 171_E 1.876 0.99
256_D 259_E 1.849 0.99
246_P 300_L 1.838 0.99
249_L 263_E 1.815 0.99
74_R 262_L 1.791 0.99
43_A 73_C 1.774 0.99
254_F 263_E 1.765 0.99
264_A 299_L 1.763 0.99
319_Q 323_H 1.714 0.99
14_I 154_Y 1.652 0.98
266_R 270_R 1.651 0.98
204_A 389_M 1.648 0.98
69_R 121_D 1.643 0.98
221_M 229_S 1.61 0.98
54_D 57_P 1.589 0.98
326_Q 329_R 1.589 0.98
236_E 373_L 1.589 0.98
73_C 113_M 1.566 0.97
231_K 363_E 1.562 0.97
148_N 151_L 1.561 0.97
86_Q 245_H 1.56 0.97
343_M 352_V 1.557 0.97
29_L 32_R 1.543 0.97
39_Y 67_N 1.531 0.97
37_V 66_E 1.526 0.97
327_L 349_Q 1.52 0.97
126_W 151_L 1.518 0.97
52_D 195_S 1.497 0.96
318_E 329_R 1.494 0.96
52_D 55_A 1.491 0.96
392_G 398_P 1.478 0.96
103_T 106_G 1.477 0.96
76_Q 112_T 1.474 0.96
273_L 362_L 1.442 0.95
236_E 372_I 1.439 0.95
323_H 348_L 1.432 0.95
115_V 151_L 1.428 0.95
58_R 61_M 1.411 0.94
397_S 402_I 1.399 0.94
79_A 257_D 1.398 0.94
40_A 68_A 1.395 0.94
399_D 402_I 1.387 0.94
12_Q 152_Q 1.386 0.94
186_S 205_K 1.372 0.93
101_N 104_P 1.362 0.93
111_G 143_Y 1.345 0.92
242_E 357_T 1.328 0.92
294_A 297_M 1.328 0.92
362_L 369_D 1.308 0.91
252_K 259_E 1.302 0.91
100_F 104_P 1.291 0.90
54_D 58_R 1.281 0.90
250_N 263_E 1.277 0.89
221_M 224_K 1.26 0.89
142_R 409_N 1.257 0.88
343_M 347_S 1.252 0.88
174_E 177_I 1.249 0.88
259_E 262_L 1.238 0.87
145_L 153_I 1.236 0.87
267_I 270_R 1.234 0.87
52_D 56_I 1.231 0.87
224_K 291_I 1.228 0.87
261_M 296_G 1.227 0.87
357_T 378_E 1.223 0.86
193_T 202_H 1.216 0.86
254_F 260_M 1.211 0.86
224_K 227_D 1.204 0.85
249_L 264_A 1.202 0.85
79_A 245_H 1.202 0.85
145_L 406_T 1.2 0.85
100_F 103_T 1.198 0.85
113_M 117_A 1.194 0.85
189_K 205_K 1.193 0.85
170_H 390_E 1.193 0.85
308_L 320_Y 1.19 0.84
238_T 361_T 1.188 0.84
193_T 200_A 1.186 0.84
102_T 106_G 1.185 0.84
263_E 267_I 1.178 0.84
361_T 376_V 1.169 0.83
307_L 360_V 1.157 0.82
248_A 253_T 1.146 0.81
234_A 271_H 1.144 0.81
319_Q 322_A 1.143 0.81
264_A 296_G 1.141 0.81
104_P 108_A 1.138 0.81
173_S 184_K 1.128 0.80
191_Y 222_G 1.123 0.79
101_N 108_A 1.119 0.79
249_L 259_E 1.117 0.79
312_H 320_Y 1.116 0.79
308_L 312_H 1.107 0.78
91_H 103_T 1.105 0.78
361_T 374_N 1.104 0.78
76_Q 80_E 1.103 0.78
197_M 261_M 1.103 0.78
76_Q 113_M 1.1 0.77
39_Y 121_D 1.1 0.77
248_A 359_E 1.094 0.77
241_F 246_P 1.092 0.77
304_Y 308_L 1.086 0.76
42_T 68_A 1.086 0.76
145_L 409_N 1.079 0.75
240_R 253_T 1.078 0.75
57_P 61_M 1.071 0.75
238_T 376_V 1.065 0.74
237_V 267_I 1.063 0.74
396_F 401_R 1.06 0.74
259_E 266_R 1.056 0.73
216_I 376_V 1.055 0.73
218_N 363_E 1.054 0.73
383_K 386_R 1.053 0.73
230_V 272_G 1.047 0.72
227_D 275_M 1.046 0.72
341_A 345_R 1.041 0.72
115_V 144_G 1.04 0.72
39_Y 66_E 1.04 0.72
240_R 249_L 1.039 0.71
231_K 234_A 1.037 0.71
75_K 258_V 1.036 0.71
236_E 361_T 1.03 0.71
91_H 101_N 1.025 0.70
256_D 260_M 1.022 0.70
185_M 205_K 1.02 0.69
101_N 107_R 1.017 0.69
115_V 148_N 1.017 0.69
220_I 223_V 1.014 0.69
103_T 107_R 1.014 0.69
102_T 199_G 1.008 0.68
296_G 299_L 1.006 0.68
170_H 174_E 1.005 0.68
219_P 226_W 1.004 0.68
115_V 147_T 1.004 0.68
69_R 117_A 1.003 0.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1k92A10.99781000.245Contact Map0.593
1vl2A40.9151000.316Contact Map0.756
2nz2A10.90381000.338Contact Map0.741
1korA40.88371000.379Contact Map0.775
2hmaA10.731599.90.85Contact Map0.32
3rjzA10.503499.80.888Contact Map0.304
2derA20.729399.70.891Contact Map0.418
1surA10.404999.70.894Contact Map0.506
2pg3A10.47299.70.898Contact Map0.385
3k32A60.44399.60.899Contact Map0.555

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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