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ATPE - ATP synthase epsilon chain
UniProt: P0A6E6 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10100
Length: 139 (137)
Sequences: 1498
Seq/Len: 10.93

ATPE
Paralog alert: 0.03 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
28_G 33_L 3.39 1.00
7_L 21_V 2.57 1.00
99_K 103_E 2.412 1.00
93_A 96_M 2.392 1.00
100_R 104_E 2.355 1.00
8_D 18_S 2.276 1.00
6_H 20_L 2.191 1.00
50_M 131_V 2.168 1.00
85_I 128_Q 2.133 1.00
26_V 70_L 2.13 1.00
33_L 42_L 1.984 1.00
97_E 100_R 1.92 1.00
5_Y 37_P 1.916 1.00
97_E 101_K 1.772 1.00
27_T 49_G 1.741 1.00
27_T 32_E 1.711 1.00
72_V 77_V 1.709 1.00
23_K 34_G 1.709 1.00
52_R 60_E 1.686 1.00
38_G 75_G 1.672 1.00
26_V 33_L 1.635 1.00
104_E 108_S 1.625 1.00
91_D 94_R 1.588 1.00
51_I 79_V 1.549 1.00
22_E 57_H 1.548 1.00
96_M 133_E 1.538 1.00
93_A 97_E 1.5 1.00
99_K 122_L 1.498 1.00
96_M 99_K 1.493 1.00
14_Q 89_D 1.477 1.00
94_R 98_A 1.463 1.00
23_K 54_V 1.43 1.00
8_D 15_Q 1.415 1.00
95_A 125_A 1.411 1.00
67_G 81_A 1.402 0.99
118_A 122_L 1.395 0.99
66_S 83_T 1.369 0.99
23_K 36_Y 1.35 0.99
32_E 47_K 1.349 0.99
92_E 132_I 1.32 0.99
51_I 65_L 1.313 0.99
100_R 103_E 1.311 0.99
63_I 86_R 1.283 0.99
24_I 51_I 1.256 0.99
119_S 123_A 1.248 0.99
92_E 129_L 1.221 0.98
96_M 100_R 1.217 0.98
4_T 22_E 1.203 0.98
43_L 71_E 1.189 0.98
86_R 89_D 1.186 0.98
104_E 107_S 1.183 0.98
130_R 133_E 1.176 0.98
24_I 77_V 1.174 0.98
44_T 70_L 1.171 0.98
28_G 42_L 1.17 0.97
63_I 84_A 1.155 0.97
5_Y 77_V 1.15 0.97
17_F 53_I 1.135 0.97
85_I 94_R 1.13 0.97
113_V 117_Q 1.127 0.97
28_G 44_T 1.122 0.97
92_E 96_M 1.106 0.96
95_A 128_Q 1.103 0.96
90_L 95_A 1.097 0.96
3_M 20_L 1.096 0.96
95_A 99_K 1.066 0.95
47_K 123_A 1.064 0.95
61_E 88_Q 1.05 0.94
22_E 54_V 1.014 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1aqtA10.99281000.088Contact Map0.702
2qe7H10.9641000.089Contact Map0.537
2e5yA20.95681000.093Contact Map0.785
2rq6A10.97121000.11Contact Map0.427
2w6jH10.94961000.128Contact Map0.508
2ck3H10.94961000.143Contact Map0.509
2xokH10.93531000.211Contact Map0.473
3ziaH20.93531000.211Contact Map0.48
3hqxA10.647529.40.919Contact Map0.168
3lnnA20.928111.30.933Contact Map0.371

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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