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CARA - Carbamoyl-phosphate synthase small chain
UniProt: P0A6F1 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10134
Length: 382 (371)
Sequences: 2054
Seq/Len: 5.54

CARA
Paralog alert: 0.08 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
255_I 274_L 4.751 1.00
96_E 104_R 4.656 1.00
193_H 215_R 4.218 1.00
212_R 368_D 3.99 1.00
195_V 219_V 3.882 1.00
52_I 81_V 3.734 1.00
30_V 130_G 3.249 1.00
326_R 341_H 3.163 1.00
194_V 374_I 2.978 1.00
163_T 221_A 2.929 1.00
283_T 316_V 2.905 1.00
55_L 80_L 2.889 1.00
89_A 94_N 2.682 1.00
33_N 48_Y 2.675 1.00
246_A 282_K 2.585 1.00
22_A 106_N 2.566 1.00
24_G 108_V 2.544 1.00
193_H 217_T 2.437 1.00
276_A 316_V 2.386 1.00
266_F 366_L 2.376 1.00
253_T 256_Q 2.313 1.00
222_Q 250_Y 2.312 1.00
284_V 315_A 2.308 1.00
10_E 129_N 2.302 1.00
219_V 223_T 2.286 1.00
204_N 207_R 2.273 1.00
99_S 103_K 2.261 1.00
318_E 330_K 2.221 1.00
326_R 343_T 2.19 1.00
11_D 121_L 2.173 1.00
168_Y 218_I 2.162 1.00
324_N 343_T 2.15 1.00
291_H 313_G 2.093 1.00
35_S 293_G 2.093 1.00
25_S 146_K 2.079 1.00
327_V 337_L 2.052 1.00
86_P 89_A 2.051 1.00
67_D 95_T 2.038 1.00
226_E 257_K 2.006 1.00
196_A 237_F 2.001 1.00
224_S 227_D 1.999 1.00
197_Y 219_V 1.987 1.00
79_G 132_I 1.96 1.00
341_H 369_H 1.956 1.00
81_V 110_I 1.939 1.00
70_E 101_Y 1.925 1.00
298_K 303_N 1.925 1.00
196_A 201_A 1.901 1.00
113_I 118_L 1.898 1.00
89_A 97_D 1.874 1.00
276_A 340_I 1.872 1.00
340_I 349_S 1.844 1.00
124_E 288_F 1.839 1.00
275_L 349_S 1.826 1.00
325_L 342_R 1.802 1.00
301_E 326_R 1.794 1.00
42_I 53_V 1.776 1.00
169_S 215_R 1.731 1.00
20_I 109_A 1.711 1.00
284_V 317_D 1.711 1.00
164_T 168_Y 1.706 1.00
225_A 229_L 1.697 1.00
236_I 258_F 1.694 1.00
145_E 149_A 1.683 1.00
52_I 79_G 1.678 1.00
174_S 211_D 1.669 1.00
262_D 345_K 1.662 1.00
15_F 121_L 1.643 0.99
18_R 112_D 1.64 0.99
259_L 347_A 1.629 0.99
56_T 119_T 1.624 0.99
82_I 85_L 1.607 0.99
282_K 317_D 1.601 0.99
8_V 144_L 1.598 0.99
342_R 346_P 1.594 0.99
49_S 76_H 1.594 0.99
214_C 371_I 1.593 0.99
342_R 345_K 1.57 0.99
219_V 231_M 1.57 0.99
52_I 130_G 1.565 0.99
275_L 347_A 1.563 0.99
192_F 375_E 1.559 0.99
157_D 160_K 1.552 0.99
214_C 374_I 1.531 0.99
69_D 93_R 1.529 0.99
324_N 344_D 1.523 0.99
279_S 325_L 1.515 0.99
306_M 365_P 1.509 0.99
279_S 342_R 1.502 0.99
195_V 231_M 1.493 0.99
196_A 206_L 1.484 0.99
253_T 257_K 1.479 0.99
5_A 110_I 1.473 0.99
266_F 348_F 1.466 0.99
159_A 270_L 1.453 0.98
97_D 100_S 1.452 0.98
236_I 263_I 1.444 0.98
199_F 238_L 1.441 0.98
298_K 330_K 1.431 0.98
208_M 364_A 1.421 0.98
43_L 77_A 1.42 0.98
197_Y 228_V 1.414 0.98
75_V 105_H 1.406 0.98
197_Y 254_A 1.403 0.98
258_F 265_V 1.399 0.98
252_I 277_L 1.394 0.98
96_E 100_S 1.391 0.98
192_F 374_I 1.387 0.98
13_T 117_K 1.368 0.97
293_G 309_A 1.342 0.97
13_T 121_L 1.333 0.97
238_L 255_I 1.331 0.97
306_M 363_A 1.329 0.97
272_H 349_S 1.328 0.97
300_V 330_K 1.314 0.97
144_L 148_R 1.306 0.96
229_L 263_I 1.303 0.96
223_T 227_D 1.302 0.96
100_S 103_K 1.302 0.96
299_D 304_V 1.296 0.96
75_V 107_I 1.295 0.96
225_A 254_A 1.287 0.96
53_V 77_A 1.285 0.96
196_A 216_L 1.278 0.96
195_V 233_P 1.272 0.96
281_A 320_T 1.267 0.96
348_F 366_L 1.264 0.95
33_N 42_I 1.254 0.95
318_E 327_V 1.253 0.95
284_V 336_T 1.242 0.95
257_K 260_E 1.239 0.95
73_S 76_H 1.232 0.95
281_A 321_L 1.231 0.95
10_E 128_Q 1.229 0.94
194_V 214_C 1.225 0.94
145_E 148_R 1.224 0.94
371_I 374_I 1.205 0.94
192_F 371_I 1.187 0.93
299_D 369_H 1.186 0.93
225_A 257_K 1.186 0.93
23_T 103_K 1.173 0.92
249_D 253_T 1.173 0.92
67_D 96_E 1.171 0.92
194_V 371_I 1.154 0.92
160_K 222_Q 1.131 0.91
259_L 275_L 1.129 0.90
352_G 363_A 1.128 0.90
18_R 111_A 1.128 0.90
227_D 230_K 1.124 0.90
66_N 69_D 1.105 0.89
199_F 251_A 1.104 0.89
151_P 156_M 1.098 0.89
8_V 14_Q 1.093 0.88
43_L 80_L 1.085 0.88
237_F 266_F 1.078 0.88
71_E 207_R 1.073 0.87
35_S 42_I 1.071 0.87
193_H 231_M 1.069 0.87
254_A 257_K 1.064 0.87
323_A 343_T 1.064 0.87
164_T 167_A 1.057 0.86
246_A 277_L 1.05 0.86
49_S 161_E 1.05 0.86
325_L 340_I 1.049 0.86
26_A 79_G 1.048 0.85
197_Y 223_T 1.042 0.85
30_V 122_L 1.041 0.85
301_E 341_H 1.037 0.85
223_T 231_M 1.037 0.85
122_L 130_G 1.034 0.84
201_A 206_L 1.03 0.84
122_L 127_A 1.028 0.84
246_A 283_T 1.021 0.83
329_H 352_G 1.016 0.83
275_L 340_I 1.016 0.83
156_M 161_E 1.007 0.82
157_D 250_Y 1.003 0.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1a9xB40.98691000.205Contact Map0.895
1s1mA20.88741000.623Contact Map0.381
1vcoA10.90311000.639Contact Map0.345
3nvaA20.8771000.673Contact Map0.411
2vxoA20.55761000.782Contact Map0.592
3tqiA40.51311000.797Contact Map0.668
1gpmA40.50521000.798Contact Map0.649
2vpiA20.53931000.799Contact Map0.574
1qdlB10.46861000.799Contact Map0.663
2ywbA40.47911000.8Contact Map0.716

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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