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CH60 - 60 kDa chaperonin
UniProt: P0A6F5 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10599
Length: 548 (527)
Sequences: 3256
Seq/Len: 6.18

CH60
Paralog alert: 0.23 [within 20: 0.03] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
135_S 497_T 4.622 1.00
131_L 497_T 4.47 1.00
126_A 129_E 4.147 1.00
487_N 490_D 4.128 1.00
274_A 325_I 3.805 1.00
479_N 482_T 3.758 1.00
130_E 133_A 3.74 1.00
160_K 164_E 3.666 1.00
479_N 486_G 3.564 1.00
465_V 485_Y 3.492 1.00
486_G 491_M 3.237 1.00
141_S 164_E 3.226 1.00
222_L 298_G 2.96 1.00
338_E 341_A 2.933 1.00
432_Q 440_I 2.923 1.00
451_L 469_V 2.893 1.00
145_A 160_K 2.884 1.00
321_K 335_G 2.878 1.00
460_E 478_Y 2.817 1.00
478_Y 483_E 2.685 1.00
339_E 343_Q 2.682 1.00
129_E 133_A 2.623 1.00
124_V 504_L 2.617 1.00
122_K 436_Q 2.523 1.00
419_L 500_T 2.519 1.00
125_T 129_E 2.47 1.00
141_S 167_D 2.461 1.00
99_I 120_I 2.432 1.00
426_L 440_I 2.416 1.00
359_D 362_R 2.404 1.00
18_R 67_E 2.391 1.00
468_T 471_G 2.39 1.00
120_I 508_A 2.369 1.00
217_S 245_K 2.342 1.00
51_K 56_V 2.328 1.00
475_N 487_N 2.32 1.00
127_A 447_M 2.295 1.00
124_V 508_A 2.272 1.00
427_A 444_L 2.252 1.00
187_L 381_V 2.221 1.00
222_L 292_I 2.152 1.00
448_E 470_K 2.148 1.00
102_E 445_R 2.119 1.00
126_A 429_L 2.085 1.00
217_S 319_Q 2.075 1.00
121_D 512_G 2.063 1.00
156_E 160_K 2.05 1.00
460_E 483_E 2.005 1.00
129_E 132_K 2.004 1.00
238_E 242_K 2.004 1.00
21_N 25_D 1.979 1.00
356_A 362_R 1.944 1.00
394_A 397_E 1.942 1.00
130_E 134_L 1.938 1.00
455_V 460_E 1.922 1.00
429_L 440_I 1.92 1.00
215_L 248_L 1.919 1.00
131_L 418_A 1.898 1.00
287_A 290_Q 1.875 1.00
479_N 491_M 1.875 1.00
214_E 322_R 1.873 1.00
340_A 343_Q 1.867 1.00
91_T 503_A 1.864 1.00
72_Q 75_K 1.86 1.00
472_G 476_Y 1.801 1.00
130_E 425_K 1.784 1.00
415_G 488_M 1.773 1.00
127_A 422_V 1.771 1.00
168_K 191_E 1.764 1.00
100_I 514_M 1.76 1.00
250_I 292_I 1.757 1.00
162_I 396_V 1.751 1.00
21_N 97_Q 1.75 1.00
343_Q 347_A 1.74 1.00
420_I 470_K 1.709 1.00
486_G 493_I 1.707 1.00
149_T 156_E 1.707 1.00
215_L 218_P 1.706 1.00
220_I 320_A 1.683 1.00
301_I 312_A 1.682 1.00
299_T 316_D 1.678 1.00
18_R 22_V 1.672 1.00
17_L 21_N 1.665 1.00
6_V 519_C 1.653 1.00
488_M 493_I 1.652 1.00
40_L 521_V 1.639 1.00
143_A 146_Q 1.618 1.00
132_K 501_R 1.615 1.00
82_N 401_H 1.608 1.00
126_A 425_K 1.596 0.99
219_F 319_Q 1.596 0.99
140_D 143_A 1.59 0.99
99_I 443_A 1.589 0.99
141_S 160_K 1.58 0.99
426_L 444_L 1.58 0.99
28_K 97_Q 1.572 0.99
128_V 132_K 1.565 0.99
425_K 428_D 1.561 0.99
437_N 441_K 1.56 0.99
216_E 322_R 1.543 0.99
48_T 394_A 1.535 0.99
166_M 407_V 1.533 0.99
46_A 387_V 1.527 0.99
443_A 508_A 1.525 0.99
10_N 14_V 1.524 0.99
115_D 436_Q 1.515 0.99
217_S 321_K 1.51 0.99
103_G 120_I 1.506 0.99
449_A 453_Q 1.506 0.99
321_K 334_D 1.499 0.99
239_A 242_K 1.495 0.99
101_T 449_A 1.483 0.99
82_N 394_A 1.474 0.99
63_E 524_L 1.472 0.99
82_N 397_E 1.469 0.99
326_N 329_T 1.462 0.99
161_L 187_L 1.449 0.99
308_E 311_K 1.448 0.99
320_A 333_I 1.446 0.99
239_A 313_T 1.444 0.99
24_A 97_Q 1.442 0.99
313_T 316_D 1.442 0.99
161_L 379_I 1.437 0.99
349_I 369_V 1.43 0.99
106_A 111_M 1.428 0.99
69_M 522_T 1.422 0.99
448_E 452_R 1.42 0.99
241_A 270_I 1.419 0.99
106_A 438_V 1.407 0.98
69_M 520_M 1.403 0.98
431_G 437_N 1.402 0.98
352_Q 355_E 1.398 0.98
411_V 494_L 1.397 0.98
213_V 274_A 1.393 0.98
467_N 471_G 1.39 0.98
319_Q 337_G 1.385 0.98
347_A 351_Q 1.385 0.98
122_K 126_A 1.377 0.98
120_I 443_A 1.376 0.98
186_E 380_K 1.375 0.98
353_I 369_V 1.371 0.98
428_D 431_G 1.364 0.98
229_N 232_E 1.363 0.98
98_A 101_T 1.336 0.98
454_I 480_A 1.336 0.98
420_I 451_L 1.334 0.98
383_A 389_M 1.324 0.97
473_D 476_Y 1.318 0.97
468_T 484_E 1.311 0.97
346_V 369_V 1.295 0.97
133_A 425_K 1.293 0.97
341_A 344_G 1.289 0.97
117_K 121_D 1.287 0.97
379_I 396_V 1.286 0.97
248_L 274_A 1.284 0.97
5_D 524_L 1.277 0.97
15_K 18_R 1.277 0.97
136_V 489_I 1.263 0.96
351_Q 355_E 1.26 0.96
166_M 175_I 1.247 0.96
432_Q 436_Q 1.246 0.96
222_L 300_V 1.243 0.96
136_V 143_A 1.236 0.96
455_V 462_P 1.227 0.95
51_K 394_A 1.224 0.95
277_K 283_D 1.219 0.95
346_V 373_A 1.216 0.95
204_F 211_G 1.204 0.95
21_N 101_T 1.203 0.95
441_K 444_L 1.202 0.95
293_A 300_V 1.201 0.95
434_E 437_N 1.2 0.95
424_S 428_D 1.194 0.94
139_S 143_A 1.193 0.94
179_D 390_K 1.184 0.94
320_A 323_V 1.184 0.94
228_S 255_E 1.18 0.94
126_A 130_E 1.172 0.94
423_A 470_K 1.171 0.94
465_V 478_Y 1.17 0.94
353_I 359_D 1.166 0.93
218_P 320_A 1.165 0.93
5_D 522_T 1.158 0.93
322_R 334_D 1.155 0.93
346_V 350_R 1.155 0.93
413_A 489_I 1.149 0.93
423_A 447_M 1.148 0.93
350_R 373_A 1.142 0.93
91_T 450_P 1.14 0.92
307_M 316_D 1.139 0.92
343_Q 380_K 1.138 0.92
523_D 526_K 1.13 0.92
254_V 275_A 1.126 0.92
205_I 211_G 1.122 0.92
240_V 243_A 1.122 0.92
421_R 474_G 1.121 0.92
417_V 421_R 1.12 0.92
418_A 422_V 1.12 0.92
441_K 445_R 1.115 0.91
126_A 440_I 1.108 0.91
445_R 449_A 1.107 0.91
301_I 316_D 1.106 0.91
347_A 354_E 1.105 0.91
214_E 324_V 1.105 0.91
147_V 411_V 1.101 0.91
50_T 391_E 1.1 0.91
431_G 440_I 1.1 0.91
473_D 487_N 1.097 0.90
181_T 186_E 1.097 0.90
207_K 210_T 1.097 0.90
157_T 185_D 1.095 0.90
433_N 440_I 1.094 0.90
424_S 427_A 1.087 0.90
406_A 410_G 1.087 0.90
7_K 66_F 1.08 0.90
25_D 28_K 1.072 0.89
249_I 333_I 1.071 0.89
409_E 498_K 1.07 0.89
348_Q 355_E 1.069 0.89
344_G 347_A 1.064 0.89
266_T 269_G 1.063 0.89
320_A 332_I 1.06 0.88
132_K 497_T 1.058 0.88
28_K 453_Q 1.058 0.88
260_A 264_V 1.057 0.88
347_A 350_R 1.057 0.88
15_K 64_D 1.053 0.88
272_K 275_A 1.05 0.88
127_A 426_L 1.049 0.88
43_S 65_K 1.046 0.87
123_A 443_A 1.043 0.87
134_L 474_G 1.043 0.87
514_M 520_M 1.043 0.87
456_L 462_P 1.043 0.87
340_A 344_G 1.038 0.87
188_D 380_K 1.037 0.87
381_V 389_M 1.034 0.87
421_R 469_V 1.034 0.87
312_A 316_D 1.032 0.86
77_V 92_A 1.032 0.86
118_R 436_Q 1.022 0.86
128_V 505_Q 1.014 0.85
20_V 514_M 1.012 0.85
164_E 191_E 1.007 0.85
469_V 472_G 1.001 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1iokA70.99271000.031Contact Map0.673
1kp8A140.99821000.032Contact Map0.689
3rtkA20.98361000.062Contact Map0.763
1we3A140.98361000.066Contact Map0.783
3ruvA40.8851000.178Contact Map0.71
1q3qA40.88141000.181Contact Map0.729
3j1bA160.8851000.186Contact Map0.748
1a6dA10.87771000.188Contact Map0.666
3p9dC20.90331000.197Contact Map0.45
1a6dB10.87771000.208Contact Map0.71

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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