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CLPP - ATP-dependent Clp protease proteolytic subunit
UniProt: P0A6G7 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10158
Length: 207 (193)
Sequences: 2411
Seq/Len: 12.49

CLPP
Paralog alert: 0.34 [within 20: 0.08] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
173_Q 177_Q 4.914 1.00
150_E 154_R 3.561 1.00
181_D 196_Y 3.157 1.00
174_S 177_Q 2.966 1.00
100_D 121_A 2.886 1.00
191_P 195_E 2.827 1.00
161_G 165_E 2.764 1.00
194_V 201_S 2.745 1.00
114_A 167_M 2.644 1.00
118_T 167_M 2.502 1.00
19_M 30_S 2.477 1.00
72_D 100_D 2.475 1.00
130_N 162_R 2.355 1.00
127_C 199_V 2.339 1.00
100_D 124_K 2.297 1.00
132_R 155_E 2.283 1.00
87_G 112_M 2.229 1.00
165_E 169_L 2.226 1.00
142_Y 152_H 2.188 1.00
50_E 53_M 2.08 1.00
65_E 99_P 2.067 1.00
72_D 124_K 2.063 1.00
45_L 75_L 1.979 1.00
127_C 133_V 1.925 1.00
194_V 199_V 1.836 1.00
101_V 121_A 1.774 1.00
164_N 182_T 1.725 1.00
158_K 192_E 1.705 1.00
45_L 49_V 1.674 1.00
118_T 170_H 1.671 1.00
191_P 194_V 1.641 1.00
47_G 53_M 1.634 1.00
74_Y 104_I 1.589 1.00
161_G 179_E 1.574 1.00
127_C 131_S 1.551 1.00
165_E 175_L 1.526 1.00
166_L 170_H 1.525 1.00
164_N 179_E 1.514 1.00
167_M 182_T 1.489 1.00
147_T 183_E 1.467 1.00
39_K 67_E 1.458 1.00
83_V 86_A 1.431 1.00
97_I 101_V 1.422 1.00
65_E 206_R 1.412 1.00
177_Q 180_R 1.392 0.99
51_D 86_A 1.39 0.99
95_Q 169_L 1.386 0.99
108_Q 132_R 1.38 0.99
85_T 108_Q 1.352 0.99
103_T 120_G 1.35 0.99
91_Y 170_H 1.344 0.99
105_C 109_A 1.338 0.99
192_E 195_E 1.335 0.99
194_V 202_I 1.308 0.99
161_G 175_L 1.293 0.99
91_Y 95_Q 1.279 0.99
126_F 201_S 1.279 0.99
138_P 160_K 1.278 0.99
189_S 192_E 1.274 0.99
167_M 178_I 1.228 0.98
115_F 167_M 1.226 0.98
175_L 179_E 1.217 0.98
122_K 172_G 1.214 0.98
51_D 83_V 1.2 0.98
140_G 156_I 1.192 0.98
150_E 157_L 1.177 0.98
127_C 194_V 1.142 0.97
79_S 113_G 1.127 0.97
68_N 71_K 1.118 0.96
49_V 53_M 1.115 0.96
111_S 136_H 1.111 0.96
117_L 133_V 1.1 0.96
74_Y 102_S 1.086 0.96
94_M 101_V 1.075 0.95
16_L 24_T 1.074 0.95
45_L 53_M 1.072 0.95
119_A 170_H 1.07 0.95
180_R 183_E 1.069 0.95
127_C 190_A 1.067 0.95
95_Q 170_H 1.061 0.95
65_E 98_K 1.059 0.95
171_T 178_I 1.048 0.94
102_S 126_F 1.044 0.94
115_F 166_L 1.041 0.94
177_Q 186_R 1.039 0.94
154_R 158_K 1.022 0.93
164_N 175_L 1.018 0.93
145_Q 156_I 1.013 0.93
23_Q 26_R 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1tg6A711000.375Contact Map0.848
1y7oA711000.426Contact Map0.87
4gm2A70.93721000.43Contact Map0.725
3p2lA70.95171000.504Contact Map0.862
2cbyA70.93721000.505Contact Map0.806
1yg6A140.93241000.508Contact Map0.854
3qwdA140.93721000.516Contact Map0.829
2f6iA70.98071000.524Contact Map0.798
4jcqA280.89861000.552Contact Map0.752
3bf0A40.97199.90.646Contact Map0.614

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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