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CLS - Cardiolipin synthase
UniProt: P0A6H8 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11608
Length: 486 (479)
Sequences: 1376
Seq/Len: 2.87

CLS
Paralog alert: 0.27 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: CLS YBHO YMDC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
137_D 236_Y 5.822 1.00
139_Q 167_A 5.814 1.00
168_A 171_R 5.342 1.00
394_K 459_L 5.31 1.00
363_D 394_K 4.261 1.00
138_I 164_S 4.166 1.00
134_L 228_I 3.887 1.00
137_D 263_R 3.63 1.00
235_A 272_M 3.54 1.00
167_A 171_R 3.237 1.00
130_V 149_F 2.881 1.00
135_I 164_S 2.872 1.00
152_W 177_L 2.809 1.00
412_G 447_A 2.706 1.00
135_I 161_V 2.696 1.00
338_I 365_S 2.621 1.00
365_S 394_K 2.619 1.00
227_M 272_M 2.608 1.00
452_D 455_S 2.607 1.00
236_Y 263_R 2.569 1.00
310_T 435_L 2.56 1.00
358_A 393_V 2.556 1.00
118_G 267_P 2.522 1.00
174_H 202_E 2.431 1.00
137_D 234_I 2.397 1.00
415_S 443_G 2.357 1.00
338_I 363_D 2.35 1.00
122_Q 133_A 2.308 1.00
415_S 446_L 2.274 1.00
120_Q 265_E 2.27 1.00
437_I 442_F 2.261 1.00
468_R 476_E 2.251 1.00
400_G 456_R 2.25 1.00
130_V 134_L 2.246 1.00
367_I 457_S 2.208 1.00
166_M 199_A 2.171 1.00
235_A 269_A 2.148 1.00
372_N 378_G 2.067 1.00
458_R 464_L 1.996 1.00
409_L 443_G 1.987 1.00
175_C 201_I 1.956 0.99
416_L 434_T 1.902 0.99
396_Y 459_L 1.895 0.99
229_M 272_M 1.888 0.99
137_D 140_L 1.884 0.99
330_A 337_L 1.88 0.99
367_I 454_I 1.866 0.99
258_I 453_Y 1.863 0.99
179_L 205_E 1.851 0.99
136_R 139_Q 1.841 0.99
133_A 236_Y 1.84 0.99
355_C 387_E 1.837 0.99
166_M 170_R 1.834 0.99
138_I 145_I 1.832 0.99
202_E 286_K 1.825 0.99
196_M 201_I 1.823 0.99
329_A 410_V 1.817 0.99
147_M 228_I 1.811 0.99
164_S 168_A 1.809 0.99
337_L 410_V 1.784 0.99
154_P 159_D 1.779 0.99
234_I 263_R 1.777 0.99
447_A 451_D 1.776 0.99
155_G 158_A 1.753 0.99
142_R 171_R 1.743 0.99
133_A 137_D 1.741 0.99
146_E 176_R 1.734 0.98
385_F 395_I 1.727 0.98
365_S 454_I 1.723 0.98
340_T 367_I 1.711 0.98
162_A 192_W 1.695 0.98
382_R 397_Q 1.685 0.98
340_T 403_L 1.683 0.98
397_Q 460_L 1.673 0.98
264_M 435_L 1.672 0.98
368_L 385_F 1.667 0.98
336_Y 447_A 1.621 0.97
162_A 195_L 1.615 0.97
139_Q 164_S 1.592 0.97
465_W 468_R 1.584 0.97
365_S 396_Y 1.583 0.97
462_A 466_L 1.57 0.97
162_A 166_M 1.569 0.97
336_Y 412_G 1.565 0.97
146_E 273_G 1.563 0.96
365_S 451_D 1.55 0.96
126_E 256_Q 1.537 0.96
385_F 397_Q 1.529 0.96
227_M 433_I 1.506 0.95
325_A 436_A 1.504 0.95
142_R 233_Y 1.503 0.95
232_N 273_G 1.493 0.95
136_R 140_L 1.492 0.95
126_E 129_D 1.485 0.95
454_I 457_S 1.477 0.95
139_Q 168_A 1.474 0.95
124_M 133_A 1.469 0.95
144_N 273_G 1.467 0.94
194_E 198_N 1.436 0.94
163_E 166_M 1.41 0.93
233_Y 265_E 1.402 0.93
132_Q 160_Q 1.392 0.92
121_L 437_I 1.388 0.92
389_L 459_L 1.378 0.92
338_I 451_D 1.376 0.92
144_N 232_N 1.371 0.91
155_G 159_D 1.371 0.91
338_I 447_A 1.37 0.91
139_Q 160_Q 1.368 0.91
123_L 449_V 1.365 0.91
148_V 223_Q 1.363 0.91
336_Y 409_L 1.356 0.91
350_L 427_L 1.353 0.91
370_R 399_E 1.344 0.90
260_L 453_Y 1.343 0.90
149_F 228_I 1.336 0.90
335_E 412_G 1.326 0.90
336_Y 363_D 1.324 0.89
164_S 171_R 1.314 0.89
399_E 458_R 1.311 0.89
368_L 381_S 1.304 0.88
122_Q 263_R 1.303 0.88
156_G 250_Q 1.302 0.88
365_S 459_L 1.296 0.88
344_F 366_I 1.29 0.88
322_I 420_V 1.287 0.88
134_L 161_V 1.272 0.87
237_T 433_I 1.25 0.86
135_I 139_Q 1.25 0.86
228_I 242_M 1.25 0.86
162_A 201_I 1.237 0.85
327_L 350_L 1.229 0.84
384_F 480_Y 1.228 0.84
363_D 459_L 1.223 0.84
130_V 261_M 1.218 0.83
380_A 486_L 1.208 0.83
448_A 452_D 1.205 0.83
390_A 462_A 1.204 0.82
124_M 236_Y 1.2 0.82
147_M 242_M 1.198 0.82
134_L 230_I 1.197 0.82
150_Y 430_N 1.197 0.82
389_L 462_A 1.196 0.82
137_D 230_I 1.189 0.81
422_L 427_L 1.184 0.81
116_V 271_A 1.184 0.81
220_D 239_S 1.183 0.81
336_Y 410_V 1.181 0.81
234_I 265_E 1.18 0.81
42_L 46_I 1.18 0.81
388_L 393_V 1.178 0.81
337_L 354_I 1.177 0.80
164_S 167_A 1.176 0.80
382_R 472_Q 1.172 0.80
121_L 442_F 1.172 0.80
139_Q 142_R 1.17 0.80
337_L 357_A 1.169 0.80
107_C 325_A 1.163 0.79
161_V 164_S 1.157 0.79
340_T 407_S 1.154 0.79
264_M 272_M 1.145 0.78
204_V 284_T 1.145 0.78
319_E 359_Q 1.122 0.76
223_Q 279_D 1.108 0.75
275_I 312_A 1.107 0.74
122_Q 445_D 1.106 0.74
412_G 444_A 1.102 0.74
178_M 283_E 1.097 0.74
133_A 136_R 1.095 0.73
156_G 244_D 1.094 0.73
129_D 132_Q 1.093 0.73
135_I 160_Q 1.091 0.73
125_T 449_V 1.088 0.73
389_L 395_I 1.081 0.72
377_V 381_S 1.079 0.72
401_G 484_P 1.078 0.72
396_Y 454_I 1.077 0.72
371_K 375_M 1.075 0.71
47_L 54_A 1.074 0.71
275_I 433_I 1.072 0.71
329_A 414_L 1.066 0.70
119_N 267_P 1.062 0.70
235_A 310_T 1.059 0.70
181_S 205_E 1.057 0.70
146_E 232_N 1.057 0.70
138_I 161_V 1.053 0.69
147_M 161_V 1.049 0.69
237_T 272_M 1.049 0.69
149_F 261_M 1.048 0.69
353_A 357_A 1.048 0.69
336_Y 365_S 1.048 0.69
264_M 268_I 1.04 0.68
206_A 239_S 1.038 0.68
239_S 450_Q 1.027 0.66
42_L 47_L 1.018 0.65
257_W 401_G 1.017 0.65
383_A 480_Y 1.015 0.65
379_W 476_E 1.013 0.65
339_M 408_V 1.012 0.65
133_A 263_R 1.012 0.65
331_Y 353_A 1.008 0.64
243_V 248_F 1.008 0.64
150_Y 374_S 1.007 0.64
386_T 465_W 1.004 0.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3hsiA30.79631000.52Contact Map0.461
1v0wA10.81481000.523Contact Map0.499
2o8rA20.84161000.632Contact Map0.478
1xdpA20.84771000.635Contact Map0.416
2c1lA20.35391000.813Contact Map0.521
4ggjA10.38271000.813Contact Map0.566
1byrA10.31481000.819Contact Map0.635
4gelA20.40741000.822Contact Map0.646
3qphA10.512398.70.928Contact Map0.206
2f5tX10.3086970.952Contact Map0.41

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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