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COAA - Pantothenate kinase
UniProt: P0A6I3 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10922
Length: 316 (308)
Sequences: 571
Seq/Len: 1.85

COAA
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
135_V 138_E 3.871 1.00
162_D 167_V 3.532 1.00
176_S 183_I 3.506 1.00
132_P 135_V 3.158 1.00
169_N 191_V 2.535 1.00
41_G 44_E 2.111 0.99
237_Q 275_M 2.108 0.99
233_E 287_K 1.997 0.99
158_K 162_D 1.896 0.98
171_T 187_D 1.85 0.98
169_N 189_T 1.849 0.98
302_T 310_E 1.811 0.97
126_T 203_V 1.788 0.97
136_L 150_S 1.747 0.96
237_Q 279_K 1.729 0.96
91_I 195_I 1.68 0.95
276_T 280_E 1.676 0.95
135_V 139_R 1.663 0.95
171_T 185_D 1.634 0.94
137_K 140_G 1.63 0.94
245_L 271_I 1.615 0.94
134_Q 138_E 1.603 0.93
144_K 175_Y 1.566 0.92
93_I 227_I 1.559 0.92
133_N 142_M 1.558 0.92
194_D 251_A 1.555 0.92
43_N 47_S 1.53 0.91
136_L 175_Y 1.526 0.91
248_R 267_K 1.494 0.90
59_S 115_W 1.493 0.90
155_R 159_F 1.476 0.89
16_D 90_I 1.467 0.89
66_I 70_L 1.46 0.88
253_T 260_H 1.45 0.88
14_Q 311_E 1.442 0.87
149_E 207_G 1.44 0.87
90_I 178_L 1.427 0.87
12_Y 30_T 1.414 0.86
174_V 186_G 1.413 0.86
221_D 296_R 1.405 0.85
301_L 312_V 1.388 0.85
24_R 28_P 1.382 0.84
178_L 257_S 1.376 0.84
304_S 310_E 1.376 0.84
108_L 294_R 1.368 0.83
24_R 60_R 1.367 0.83
162_D 227_I 1.347 0.82
132_P 181_D 1.346 0.82
168_P 191_V 1.343 0.82
79_F 225_F 1.329 0.81
206_S 221_D 1.317 0.80
24_R 30_T 1.297 0.79
134_Q 181_D 1.293 0.78
163_L 196_L 1.287 0.78
30_T 62_L 1.271 0.77
273_T 277_L 1.267 0.76
88_P 91_I 1.248 0.75
237_Q 283_W 1.247 0.75
258_Y 314_L 1.24 0.74
152_D 182_V 1.221 0.72
176_S 231_A 1.22 0.72
35_E 114_R 1.215 0.72
21_A 103_T 1.212 0.72
130_L 136_L 1.21 0.71
147_F 159_F 1.208 0.71
173_P 231_A 1.206 0.71
32_S 46_L 1.194 0.70
151_Y 257_S 1.19 0.70
77_E 313_R 1.186 0.69
238_T 242_N 1.171 0.68
63_N 157_V 1.166 0.67
13_L 93_I 1.159 0.67
59_S 62_L 1.157 0.67
210_Y 214_P 1.155 0.66
151_Y 159_F 1.145 0.65
88_P 128_G 1.145 0.65
257_S 289_N 1.145 0.65
34_D 246_K 1.144 0.65
92_S 223_V 1.144 0.65
52_A 90_I 1.143 0.65
112_L 195_I 1.141 0.65
13_L 26_S 1.135 0.64
28_P 60_R 1.133 0.64
34_D 38_R 1.128 0.64
77_E 312_V 1.126 0.63
249_E 267_K 1.12 0.63
16_D 19_Q 1.118 0.63
136_L 151_Y 1.118 0.63
17_R 23_L 1.116 0.62
29_M 140_G 1.107 0.61
56_L 60_R 1.106 0.61
14_Q 167_V 1.105 0.61
42_I 309_V 1.105 0.61
84_G 313_R 1.103 0.61
262_Y 281_I 1.098 0.61
211_P 214_P 1.096 0.60
225_F 299_L 1.096 0.60
135_V 284_L 1.087 0.59
131_H 189_T 1.086 0.59
88_P 175_Y 1.082 0.59
234_D 238_T 1.08 0.59
14_Q 313_R 1.075 0.58
263_A 266_T 1.075 0.58
159_F 182_V 1.074 0.58
104_T 301_L 1.072 0.58
67_S 117_E 1.071 0.58
51_V 172_A 1.07 0.58
134_Q 175_Y 1.068 0.57
241_I 258_Y 1.067 0.57
72_R 76_L 1.063 0.57
194_D 252_F 1.062 0.57
126_T 151_Y 1.056 0.56
18_N 86_R 1.054 0.56
264_K 267_K 1.047 0.55
249_E 253_T 1.047 0.55
238_T 305_A 1.041 0.54
111_L 120_R 1.039 0.54
60_R 115_W 1.034 0.54
122_E 258_Y 1.033 0.54
175_Y 181_D 1.032 0.53
26_S 63_N 1.031 0.53
147_F 181_D 1.031 0.53
147_F 151_Y 1.028 0.53
266_T 269_E 1.026 0.53
72_R 223_V 1.026 0.53
220_S 224_D 1.02 0.52
129_F 159_F 1.015 0.52
109_Q 195_I 1.014 0.52
294_R 306_N 1.012 0.51
10_T 316_K 1.012 0.51
137_K 141_L 1.011 0.51
99_V 230_D 1.009 0.51
12_Y 105_A 1.008 0.51
267_K 271_I 1.006 0.51
35_E 51_V 1.006 0.51
86_R 120_R 1.005 0.51
63_N 118_H 1.003 0.50
24_R 56_L 1 0.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tqcA211000.538Contact Map0.488
4bfzA20.97151000.607Contact Map0.43
4gi7A811000.649Contact Map0.484
1odfA10.78481000.722Contact Map0.34
2ga8A10.70571000.753Contact Map0.448
2jeoA10.683599.90.812Contact Map0.447
1a7jA10.642499.90.813Contact Map0.208
1rz3A10.623499.80.825Contact Map0.34
3c8uA10.658299.80.839Contact Map0.395
1uj2A20.686799.80.843Contact Map0.443

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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