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COAD - Phosphopantetheine adenylyltransferase
UniProt: P0A6I6 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11190
Length: 159 (156)
Sequences: 1649
Seq/Len: 10.57

COAD
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
31_H 66_E 5.772 1.00
68_V 77_F 3.905 1.00
14_I 55_A 3.425 1.00
68_V 81_Q 3.102 1.00
25_A 87_I 3.017 1.00
23_T 61_H 2.805 1.00
6_I 78_A 2.771 1.00
26_T 64_N 2.7 1.00
50_E 157_K 2.351 1.00
47_T 50_E 2.226 1.00
58_A 149_N 2.049 1.00
54_L 153_A 2.021 1.00
14_I 22_V 1.991 1.00
29_F 32_V 1.984 1.00
108_H 144_H 1.952 1.00
53_A 56_Q 1.942 1.00
10_T 44_P 1.849 1.00
19_I 147_P 1.795 1.00
5_A 32_V 1.782 1.00
79_R 110_M 1.776 1.00
88_R 102_L 1.775 1.00
135_V 140_G 1.697 1.00
52_V 56_Q 1.654 1.00
151_H 155_M 1.654 1.00
86_L 113_L 1.625 1.00
152_Q 156_A 1.621 1.00
53_A 57_Q 1.616 1.00
75_A 110_M 1.593 1.00
33_I 81_Q 1.593 1.00
146_L 150_V 1.566 1.00
20_D 121_S 1.554 1.00
78_A 113_L 1.528 1.00
19_I 59_T 1.517 1.00
52_V 69_G 1.498 1.00
46_F 54_L 1.435 1.00
57_Q 60_A 1.419 1.00
24_R 114_E 1.417 1.00
32_V 87_I 1.413 1.00
76_N 79_R 1.41 1.00
35_A 70_F 1.397 0.99
59_T 62_L 1.383 0.99
10_T 37_A 1.375 0.99
77_F 81_Q 1.357 0.99
105_M 135_V 1.347 0.99
57_Q 153_A 1.346 0.99
79_R 112_E 1.341 0.99
57_Q 149_N 1.317 0.99
4_R 31_H 1.263 0.99
74_M 86_L 1.234 0.98
92_A 100_M 1.233 0.98
41_S 134_E 1.209 0.98
148_E 152_Q 1.207 0.98
105_M 131_L 1.203 0.98
36_I 52_V 1.142 0.97
16_N 147_P 1.141 0.97
90_L 96_F 1.137 0.97
58_A 147_P 1.133 0.97
28_M 118_L 1.115 0.96
48_L 69_G 1.112 0.96
143_T 151_H 1.107 0.96
153_A 156_A 1.103 0.96
6_I 77_F 1.1 0.96
92_A 101_Q 1.099 0.96
28_M 116_V 1.082 0.96
142_V 154_L 1.081 0.95
21_I 118_L 1.072 0.95
14_I 150_V 1.056 0.95
75_A 113_L 1.045 0.94
103_A 117_F 1.04 0.94
104_H 125_S 1.032 0.94
134_E 138_H 1.032 0.94
34_L 59_T 1.027 0.94
45_M 158_L 1.025 0.93
74_M 102_L 1.015 0.93
40_P 138_H 1.01 0.93
49_E 53_A 1.007 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1vlhA611000.496Contact Map0.867
3k9wA111000.498Contact Map0.781
3nbkA40.99371000.506Contact Map0.81
3nd5A611000.507Contact Map0.81
3f3mA111000.51Contact Map0.724
1od6A10.98741000.512Contact Map0.778
4f3rA30.99371000.515Contact Map0.767
1o6bA111000.516Contact Map0.728
1qjcA20.99371000.517Contact Map0.809
3nv7A10.98741000.521Contact Map0.529

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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