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COAE - Dephospho-CoA kinase
UniProt: P0A6I9 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12312
Length: 206 (196)
Sequences: 2313
Seq/Len: 11.80

COAE
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
149_R 153_E 3.279 1.00
53_H 83_W 3.166 1.00
116_V 168_V 2.616 1.00
88_L 92_I 2.604 1.00
95_E 98_H 2.582 1.00
141_T 152_V 2.229 1.00
80_E 83_W 2.183 1.00
129_V 169_A 2.175 1.00
126_R 171_D 2.092 1.00
51_A 59_I 2.081 1.00
25_L 187_A 2.035 1.00
71_R 155_I 2.01 1.00
133_S 176_N 1.96 1.00
139_K 143_Q 1.893 1.00
46_A 91_L 1.892 1.00
95_E 99_Q 1.862 1.00
24_D 183_A 1.805 1.00
47_L 65_L 1.79 1.00
178_A 181_A 1.787 1.00
74_I 81_K 1.785 1.00
49_A 91_L 1.742 1.00
116_V 127_V 1.736 1.00
131_D 162_R 1.732 1.00
133_S 136_T 1.727 1.00
53_H 80_E 1.699 1.00
7_L 19_A 1.667 1.00
27_I 109_L 1.658 1.00
121_Y 168_V 1.645 1.00
12_G 141_T 1.587 1.00
60_A 64_T 1.577 1.00
60_A 66_Q 1.567 1.00
18_V 182_I 1.56 1.00
128_L 189_L 1.544 1.00
21_A 183_A 1.542 1.00
50_I 84_L 1.524 1.00
69_A 72_E 1.501 1.00
18_V 186_V 1.497 1.00
164_A 167_A 1.485 1.00
110_W 124_A 1.479 1.00
21_A 187_A 1.454 1.00
38_Q 99_Q 1.439 1.00
40_V 50_I 1.432 1.00
74_I 84_L 1.43 1.00
142_M 149_R 1.401 0.99
73_R 80_E 1.399 0.99
18_V 130_V 1.39 0.99
22_F 109_L 1.388 0.99
100_I 108_V 1.386 0.99
131_D 166_L 1.38 0.99
35_I 95_E 1.362 0.99
136_T 139_K 1.352 0.99
128_L 171_D 1.351 0.99
134_P 153_E 1.337 0.99
153_E 157_A 1.334 0.99
16_S 20_N 1.328 0.99
27_I 190_H 1.327 0.99
83_W 86_A 1.319 0.99
38_Q 95_E 1.318 0.99
83_W 87_L 1.314 0.99
138_L 153_E 1.309 0.99
164_A 168_V 1.309 0.99
30_I 35_I 1.308 0.99
137_Q 162_R 1.296 0.99
161_T 164_A 1.289 0.99
12_G 152_V 1.289 0.99
42_P 64_T 1.286 0.99
171_D 193_Y 1.283 0.99
107_Y 190_H 1.28 0.99
77_N 80_E 1.277 0.99
32_A 96_T 1.275 0.99
47_L 51_A 1.259 0.99
142_M 152_V 1.247 0.99
5_V 128_L 1.234 0.98
41_E 64_T 1.233 0.98
6_A 115_L 1.219 0.98
132_V 136_T 1.219 0.98
19_A 111_V 1.207 0.98
65_L 70_L 1.207 0.98
147_V 155_I 1.176 0.98
116_V 160_A 1.174 0.98
58_M 73_R 1.172 0.98
23_A 29_V 1.172 0.98
117_E 165_R 1.169 0.97
6_A 124_A 1.149 0.97
185_D 188_R 1.146 0.97
53_H 87_L 1.143 0.97
13_S 162_R 1.142 0.97
20_N 23_A 1.137 0.97
78_P 81_K 1.132 0.97
171_D 189_L 1.129 0.97
40_V 65_L 1.126 0.97
7_L 109_L 1.123 0.97
161_T 165_R 1.121 0.97
58_M 69_A 1.114 0.96
190_H 194_L 1.102 0.96
147_V 152_V 1.1 0.96
132_V 137_Q 1.1 0.96
151_H 155_I 1.1 0.96
50_I 58_M 1.093 0.96
151_H 154_Q 1.092 0.96
96_T 110_W 1.092 0.96
138_L 149_R 1.086 0.96
21_A 25_L 1.077 0.95
49_A 52_D 1.075 0.95
13_S 137_Q 1.07 0.95
39_V 88_L 1.069 0.95
162_R 165_R 1.055 0.95
28_N 103_A 1.05 0.94
160_A 165_R 1.045 0.94
82_N 85_N 1.032 0.94
129_V 165_R 1.029 0.94
137_Q 156_L 1.026 0.94
36_A 40_V 1.025 0.93
66_Q 69_A 1.022 0.93
40_V 88_L 1.016 0.93
81_K 158_A 1.015 0.93
72_E 151_H 1.011 0.93
160_A 164_A 1.011 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1dekA20.87381000.411Contact Map0.27
1uf9A30.95631000.451Contact Map0.716
2if2A30.98061000.458Contact Map0.815
1vhtA311000.459Contact Map0.794
4i1uA20.97091000.462Contact Map0.809
2grjA80.87381000.464Contact Map0.804
2f6rA10.97571000.478Contact Map0.78
1jjvA10.98061000.506Contact Map0.788
3akeA10.91751000.568Contact Map0.509
1rz3A10.796199.90.588Contact Map0.501

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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