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HSCB - Co-chaperone protein HscB
UniProt: P0A6L9 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12131
Length: 171 (170)
Sequences: 554
Seq/Len: 3.26

HSCB
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
101_E 120_R 2.48 1.00
99_R 160_S 2.364 1.00
2_D 11_A 2.349 1.00
14_Q 133_V 2.29 1.00
3_Y 70_Y 2.177 1.00
114_L 161_A 2.073 1.00
135_Q 147_T 1.948 1.00
68_A 148_V 1.875 0.99
40_S 43_E 1.751 0.99
28_Q 151_L 1.741 0.99
26_D 29_R 1.731 0.99
93_M 100_E 1.709 0.99
95_Q 153_F 1.691 0.99
2_D 5_T 1.68 0.98
44_Q 51_S 1.622 0.98
24_F 60_T 1.583 0.98
140_T 143_A 1.555 0.97
60_T 70_Y 1.543 0.97
63_H 66_M 1.513 0.97
27_L 54_I 1.484 0.96
31_Y 54_I 1.482 0.96
23_R 27_L 1.48 0.96
134_E 138_N 1.455 0.95
6_L 42_A 1.454 0.95
12_R 137_D 1.418 0.94
64_P 93_M 1.414 0.94
44_Q 125_F 1.412 0.94
95_Q 98_L 1.366 0.93
88_D 165_E 1.353 0.92
2_D 35_K 1.341 0.92
3_Y 53_T 1.307 0.91
63_H 155_D 1.269 0.89
105_I 117_F 1.263 0.89
132_M 136_L 1.244 0.88
111_E 169_L 1.24 0.87
11_A 74_L 1.208 0.85
118_I 161_A 1.208 0.85
25_Q 152_R 1.206 0.85
48_V 52_A 1.204 0.85
50_Q 53_T 1.199 0.85
125_F 151_L 1.196 0.85
156_K 160_S 1.183 0.84
14_Q 130_Q 1.166 0.83
90_A 126_D 1.159 0.82
117_F 164_L 1.155 0.82
93_M 97_E 1.151 0.82
149_R 153_F 1.143 0.81
59_Q 66_M 1.136 0.80
25_Q 29_R 1.132 0.80
124_M 154_L 1.124 0.79
128_R 147_T 1.117 0.79
91_F 98_L 1.112 0.78
39_G 43_E 1.11 0.78
52_A 88_D 1.11 0.78
91_F 153_F 1.109 0.78
40_S 96_L 1.108 0.78
132_M 151_L 1.102 0.77
72_L 157_L 1.094 0.77
16_D 19_A 1.093 0.77
23_R 29_R 1.089 0.76
136_L 141_W 1.081 0.76
131_L 134_E 1.08 0.75
6_L 25_Q 1.061 0.74
41_Q 44_Q 1.061 0.74
69_E 151_L 1.061 0.74
8_G 44_Q 1.055 0.73
49_Q 54_I 1.054 0.73
45_L 95_Q 1.053 0.73
24_F 72_L 1.048 0.72
32_H 55_N 1.042 0.72
23_R 44_Q 1.04 0.71
91_F 99_R 1.038 0.71
132_M 135_Q 1.032 0.71
123_K 126_D 1.032 0.71
94_E 120_R 1.032 0.71
135_Q 144_A 1.03 0.70
126_D 130_Q 1.027 0.70
68_A 99_R 1.026 0.70
58_W 65_L 1.022 0.70
85_T 149_R 1.019 0.69
53_T 56_Q 1.018 0.69
28_Q 34_D 1.017 0.69
69_E 152_R 1.003 0.67
99_R 156_K 1.003 0.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1fpoA311000.227Contact Map0.589
3hhoA40.99421000.227Contact Map0.569
3bvoA20.96491000.255Contact Map0.519
3uo3A20.92981000.32Contact Map0.534
2l6lA10.801299.70.639Contact Map0.188
1wjzA10.456199.40.716Contact Map0.486
1n4cA10.38699.30.729Contact Map0.239
1fafA10.403599.30.73Contact Map0.216
2yuaA10.485499.30.735Contact Map0.366
2cugA10.421199.20.74Contact Map0.455

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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