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TPX - Thiol peroxidase
UniProt: P0A862 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12672
Length: 168 (150)
Sequences: 7779
Seq/Len: 51.86

TPX
Paralog alert: 0.86 [within 20: 0.09] - ratio of genomes with paralogs
Cluster includes: AHPC BCP DSBE TPX
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
47_R 140_E 3.897 1.00
29_T 37_D 3.082 1.00
46_K 79_V 3.049 1.00
25_A 118_Y 2.85 1.00
56_I 91_Q 2.776 1.00
32_A 36_S 2.647 1.00
139_D 145_I 2.523 1.00
29_T 39_T 2.502 1.00
139_D 143_N 2.465 1.00
69_N 102_N 2.455 1.00
24_K 143_N 2.314 1.00
72_A 76_D 2.202 1.00
31_V 37_D 2.126 1.00
39_T 42_Q 2.057 1.00
27_T 41_G 2.054 1.00
113_E 117_A 1.997 1.00
71_L 74_E 1.991 1.00
20_Q 23_S 1.985 1.00
27_T 39_T 1.935 1.00
30_L 106_L 1.897 1.00
38_V 43_F 1.576 1.00
44_A 48_K 1.536 1.00
33_K 95_C 1.512 1.00
48_K 142_D 1.506 1.00
48_K 79_V 1.482 1.00
57_D 93_R 1.481 1.00
78_T 166_L 1.479 1.00
73_T 76_D 1.474 1.00
82_C 105_T 1.461 1.00
122_I 132_A 1.453 1.00
160_E 164_A 1.451 1.00
67_K 71_L 1.434 1.00
49_V 137_V 1.427 1.00
30_L 114_F 1.379 0.99
48_K 81_L 1.372 0.99
41_G 44_A 1.366 0.99
115_L 131_A 1.36 0.99
71_L 160_E 1.358 0.99
43_F 81_L 1.333 0.99
43_F 48_K 1.328 0.99
146_F 165_V 1.319 0.99
65_V 100_L 1.306 0.99
72_A 102_N 1.271 0.99
52_I 83_I 1.266 0.99
85_A 115_L 1.255 0.99
93_R 96_G 1.241 0.98
32_A 38_V 1.239 0.98
85_A 112_A 1.235 0.98
92_S 96_G 1.226 0.98
76_D 79_V 1.203 0.98
67_K 70_Q 1.194 0.98
74_E 160_E 1.191 0.98
88_P 92_S 1.179 0.98
120_V 136_V 1.179 0.98
27_T 40_L 1.176 0.98
73_T 102_N 1.155 0.97
71_L 159_Y 1.144 0.97
32_A 106_L 1.134 0.97
25_A 138_I 1.13 0.97
89_F 93_R 1.13 0.97
138_I 144_V 1.129 0.97
48_K 138_I 1.122 0.97
82_C 103_V 1.119 0.96
114_F 118_Y 1.111 0.96
31_V 88_P 1.107 0.96
49_V 135_V 1.097 0.96
47_R 137_V 1.096 0.96
62_A 98_E 1.096 0.96
87_L 90_A 1.086 0.96
66_R 70_Q 1.065 0.95
50_L 138_I 1.065 0.95
51_N 65_V 1.061 0.95
32_A 104_I 1.055 0.95
112_A 121_A 1.045 0.94
25_A 144_V 1.041 0.94
74_E 167_K 1.037 0.94
51_N 64_S 1.029 0.94
69_N 103_V 1.013 0.93
19_P 144_V 1.011 0.93
64_S 135_V 1.003 0.93
58_T 133_R 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4je1A20.98811000.23Contact Map0.588
1xvqA10.97021000.234Contact Map0.604
1q98A20.98211000.238Contact Map0.709
2yzhA40.98811000.243Contact Map0.743
3zrdA20.9941000.247Contact Map0.697
2v2gA40.8811000.252Contact Map0.75
3p7xA40.97021000.257Contact Map0.765
1prxA20.89291000.265Contact Map0.688
1xvwA20.90481000.265Contact Map0.788
1psqA20.95831000.266Contact Map0.734

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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