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PRMA - Ribosomal protein L11 methyltransferase
UniProt: P0A8T1 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11497
Length: 293 (292)
Sequences: 1351
Seq/Len: 4.63

PRMA
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
247_P 251_G 3.743 1.00
225_D 248_V 3.741 1.00
143_P 283_E 3.315 1.00
167_C 197_S 3.304 1.00
177_L 184_A 3.217 1.00
149_L 175_A 3.119 1.00
117_S 132_D 2.743 1.00
150_Q 282_K 2.701 1.00
227_V 247_P 2.376 1.00
159_G 182_A 2.317 1.00
183_K 211_E 2.309 1.00
186_G 210_L 2.249 1.00
107_R 126_A 2.225 1.00
146_S 282_K 2.219 1.00
279_V 288_I 2.101 1.00
154_S 278_P 2.073 1.00
264_E 268_E 2.048 1.00
260_A 281_E 2.034 1.00
111_R 153_D 2.029 1.00
263_A 286_C 2.011 1.00
162_V 176_A 1.983 1.00
266_V 269_A 1.938 1.00
237_R 266_V 1.925 1.00
98_E 101_D 1.924 1.00
163_I 224_A 1.913 1.00
177_L 209_R 1.9 1.00
151_W 289_T 1.9 1.00
93_K 98_E 1.892 1.00
197_S 212_L 1.85 1.00
5_Q 88_E 1.848 1.00
232_L 262_Q 1.835 1.00
156_D 160_K 1.82 1.00
144_T 256_S 1.8 1.00
115_C 130_M 1.797 1.00
263_A 279_V 1.79 1.00
112_L 149_L 1.756 1.00
161_T 183_K 1.755 1.00
44_L 47_E 1.753 1.00
275_A 291_R 1.716 0.99
157_L 160_K 1.688 0.99
269_A 272_D 1.683 0.99
244_S 274_F 1.677 0.99
240_A 270_Y 1.675 0.99
177_L 210_L 1.643 0.99
150_Q 280_V 1.636 0.99
186_G 197_S 1.599 0.99
186_G 212_L 1.59 0.99
247_P 274_F 1.577 0.99
109_G 150_Q 1.57 0.99
252_L 291_R 1.567 0.99
240_A 266_V 1.559 0.99
127_V 178_K 1.536 0.99
97_R 100_M 1.532 0.99
242_L 245_V 1.526 0.98
5_Q 31_T 1.503 0.98
100_M 118_W 1.445 0.98
109_G 153_D 1.443 0.98
162_V 181_A 1.442 0.98
231_I 235_P 1.441 0.98
173_A 210_L 1.438 0.98
104_H 119_R 1.435 0.97
151_W 287_R 1.434 0.97
237_R 265_S 1.422 0.97
114_I 149_L 1.42 0.97
112_L 175_A 1.41 0.97
116_P 133_P 1.388 0.97
152_L 157_L 1.387 0.97
173_A 184_A 1.377 0.97
184_A 210_L 1.376 0.97
115_C 128_N 1.356 0.96
111_R 127_V 1.352 0.96
201_A 206_V 1.341 0.96
276_L 279_V 1.338 0.96
6_L 87_I 1.336 0.96
201_A 210_L 1.334 0.96
270_Y 290_G 1.323 0.95
236_L 255_L 1.317 0.95
191_P 195_Q 1.313 0.95
226_V 252_L 1.311 0.95
199_D 202_E 1.31 0.95
198_R 202_E 1.302 0.95
106_M 141_T 1.296 0.95
116_P 119_R 1.29 0.94
276_L 288_I 1.286 0.94
236_L 270_Y 1.283 0.94
281_E 286_C 1.272 0.94
174_I 206_V 1.251 0.93
154_S 280_V 1.246 0.93
2_P 89_Q 1.222 0.92
20_D 24_E 1.219 0.92
170_G 197_S 1.206 0.91
202_E 207_S 1.204 0.91
267_C 290_G 1.201 0.91
260_A 284_E 1.197 0.91
281_E 284_E 1.196 0.91
267_C 271_A 1.185 0.90
96_E 99_W 1.176 0.90
233_A 266_V 1.173 0.90
162_V 226_V 1.172 0.90
131_L 169_S 1.169 0.90
185_I 211_E 1.168 0.90
118_W 133_P 1.165 0.89
228_V 254_G 1.165 0.89
263_A 288_I 1.162 0.89
147_L 232_L 1.159 0.89
65_D 68_D 1.155 0.89
5_Q 57_I 1.14 0.88
99_W 102_N 1.134 0.88
110_E 153_D 1.132 0.88
235_P 270_Y 1.126 0.87
169_S 233_A 1.123 0.87
267_C 279_V 1.12 0.87
113_W 121_V 1.112 0.86
244_S 292_K 1.109 0.86
259_L 262_Q 1.101 0.86
97_R 101_D 1.1 0.85
147_L 287_R 1.098 0.85
42_E 47_E 1.096 0.85
167_C 173_A 1.092 0.85
162_V 228_V 1.082 0.84
41_F 47_E 1.073 0.84
121_V 128_N 1.07 0.83
113_W 126_A 1.069 0.83
263_A 267_C 1.064 0.83
226_V 254_G 1.062 0.83
227_V 243_I 1.06 0.83
106_M 171_I 1.055 0.82
41_F 44_L 1.055 0.82
262_Q 265_S 1.052 0.82
195_Q 199_D 1.046 0.81
161_T 182_A 1.042 0.81
68_D 114_I 1.042 0.81
67_N 71_A 1.032 0.80
276_L 290_G 1.031 0.80
264_E 267_C 1.03 0.80
165_F 187_I 1.026 0.80
25_A 60_F 1.025 0.79
162_V 184_A 1.014 0.78
258_I 266_V 1.011 0.78
133_P 147_L 1.007 0.78
10_T 14_N 1.001 0.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2nxcA10.85671000.401Contact Map0.716
3grzA20.65531000.643Contact Map0.806
3gczA10.716799.90.712Contact Map0.478
3b3jA10.907899.90.726Contact Map0.724
3bzbA20.672499.90.743Contact Map0.754
3dmgA10.928399.90.747Contact Map0.661
1u2zA30.972799.90.748Contact Map0.46
3lcvB10.808999.90.756Contact Map0.322
3gnlA20.525699.80.766Contact Map0.598
3axsA10.634899.80.768Contact Map0.614

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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