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RBN - Ribonuclease BN
UniProt: P0A8V0 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14260
Length: 305 (302)
Sequences: 2786
Seq/Len: 9.23

RBN
Paralog alert: 0.35 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: PHNP RBN
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
208_A 226_V 4.491 1.00
227_D 264_G 3.472 1.00
90_T 119_V 3.389 1.00
5_F 8_T 3.237 1.00
2_E 302_V 2.859 1.00
135_T 151_E 2.839 1.00
5_F 297_A 2.839 1.00
225_G 262_G 2.767 1.00
149_R 206_A 2.746 1.00
37_F 150_I 2.714 1.00
265_K 295_E 2.695 1.00
90_T 117_E 2.402 1.00
2_E 25_N 2.339 1.00
137_Y 222_L 2.323 1.00
231_H 249_S 2.319 1.00
177_E 182_K 2.253 1.00
228_V 267_I 2.199 1.00
20_T 209_I 2.185 1.00
221_D 224_K 2.167 1.00
237_I 252_R 2.091 1.00
267_I 303_F 2.082 1.00
61_F 134_V 2.062 1.00
98_R 102_E 2.038 1.00
46_Q 49_H 2.028 1.00
206_A 226_V 2.024 1.00
208_A 223_A 1.979 1.00
59_K 90_T 1.969 1.00
256_T 260_E 1.95 1.00
133_K 151_E 1.892 1.00
258_A 266_L 1.889 1.00
207_L 230_V 1.862 1.00
139_L 145_C 1.806 1.00
21_A 43_T 1.769 1.00
220_L 260_E 1.755 1.00
267_I 297_A 1.751 1.00
2_E 304_N 1.746 1.00
25_N 34_L 1.715 1.00
295_E 301_T 1.683 1.00
210_F 231_H 1.645 1.00
284_L 288_R 1.644 1.00
139_L 147_G 1.642 1.00
267_I 295_E 1.636 1.00
4_I 302_V 1.612 1.00
98_R 120_E 1.612 1.00
176_Q 180_A 1.583 1.00
233_A 254_A 1.575 1.00
192_I 197_Y 1.57 1.00
92_Y 119_V 1.567 1.00
128_D 133_K 1.56 1.00
258_A 263_V 1.557 1.00
269_T 297_A 1.546 1.00
50_T 300_F 1.545 1.00
151_E 206_A 1.521 1.00
5_F 22_I 1.491 1.00
183_T 194_G 1.489 1.00
223_A 226_V 1.485 1.00
167_A 197_Y 1.467 1.00
145_C 211_G 1.466 1.00
33_G 58_D 1.464 1.00
297_A 301_T 1.434 0.99
255_A 290_I 1.422 0.99
298_N 301_T 1.415 0.99
95_Q 120_E 1.407 0.99
226_V 263_V 1.398 0.99
60_I 73_L 1.379 0.99
152_E 205_K 1.374 0.99
139_L 210_F 1.371 0.99
147_G 210_F 1.357 0.99
186_L 190_R 1.352 0.99
69_H 270_H 1.35 0.99
193_N 196_D 1.338 0.99
46_Q 300_F 1.331 0.99
149_R 226_V 1.314 0.99
23_L 34_L 1.309 0.99
8_T 17_R 1.308 0.99
93_G 97_I 1.305 0.99
223_A 261_A 1.302 0.99
96_G 120_E 1.295 0.99
63_S 148_Y 1.293 0.99
3_L 207_L 1.291 0.99
252_R 289_S 1.283 0.99
128_D 153_H 1.282 0.99
140_E 214_G 1.277 0.99
37_F 61_F 1.276 0.99
17_R 299_D 1.275 0.99
62_I 73_L 1.275 0.99
217_D 260_E 1.267 0.98
251_T 255_A 1.25 0.98
163_A 166_A 1.248 0.98
160_N 163_A 1.229 0.98
65_L 96_G 1.227 0.98
268_I 287_C 1.224 0.98
63_S 209_I 1.216 0.98
22_I 269_T 1.216 0.98
230_V 269_T 1.215 0.98
250_S 253_Q 1.208 0.98
62_I 97_I 1.206 0.98
214_G 253_Q 1.202 0.98
255_A 291_F 1.19 0.97
281_Q 284_L 1.187 0.97
3_L 24_L 1.171 0.97
256_T 259_R 1.17 0.97
225_G 264_G 1.162 0.97
185_T 191_Q 1.159 0.97
183_T 193_N 1.145 0.97
35_W 150_I 1.143 0.96
224_K 262_G 1.133 0.96
100_F 104_A 1.128 0.96
126_I 135_T 1.124 0.96
263_V 266_L 1.124 0.96
61_F 148_Y 1.122 0.96
39_C 62_I 1.121 0.96
8_T 299_D 1.12 0.96
220_L 257_L 1.118 0.96
22_I 37_F 1.116 0.96
218_A 221_D 1.115 0.96
36_L 43_T 1.115 0.96
95_Q 122_G 1.112 0.96
5_F 230_V 1.105 0.95
59_K 92_Y 1.098 0.95
138_P 144_E 1.098 0.95
194_G 197_Y 1.088 0.95
4_I 25_N 1.086 0.95
88_P 117_E 1.076 0.95
213_T 219_A 1.072 0.94
220_L 261_A 1.071 0.94
126_I 136_A 1.066 0.94
149_R 208_A 1.063 0.94
3_L 230_V 1.063 0.94
210_F 219_A 1.056 0.94
67_G 71_F 1.056 0.94
99_E 106_R 1.055 0.94
134_V 150_I 1.054 0.94
5_F 267_I 1.053 0.94
282_H 286_E 1.049 0.94
284_L 296_L 1.045 0.93
160_N 199_A 1.032 0.93
164_L 197_Y 1.023 0.92
209_I 230_V 1.018 0.92
9_S 17_R 1.017 0.92
77_L 89_L 1.013 0.92
88_P 115_P 1.012 0.92
235_L 246_R 1.007 0.92
43_T 47_L 1.003 0.91
232_E 249_S 1.003 0.91
255_A 258_A 1 0.91
236_D 283_L 1 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3zwfA20.98691000.172Contact Map0.839
2cbnA111000.214Contact Map0.831
1y44A20.99671000.214Contact Map0.883
2e7yA20.85571000.427Contact Map0.652
1zkpA40.78361000.442Contact Map0.837
3jxpA10.81000.457Contact Map0.689
3g1pA20.74431000.489Contact Map0.819
3md7A10.75741000.503Contact Map0.767
3bk2A10.76721000.587Contact Map0.522
2az4A20.75081000.601Contact Map0.566

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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