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BLC - Outer membrane lipoprotein blc
UniProt: P0A901 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12474
Length: 177 (168)
Sequences: 788
Seq/Len: 4.69

BLC
Paralog alert: 0.18 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
57_L 78_G 2.94 1.00
65_S 73_N 2.884 1.00
67_R 71_G 2.666 1.00
103_A 117_N 2.564 1.00
122_D 126_R 2.532 1.00
36_A 72_L 2.475 1.00
152_K 171_W 2.426 1.00
138_L 169_F 2.096 1.00
62_A 76_N 1.991 1.00
77_K 88_Q 1.981 1.00
45_E 48_R 1.979 1.00
131_C 164_F 1.976 1.00
34_F 118_V 1.907 1.00
158_V 161_R 1.874 1.00
73_N 90_E 1.863 1.00
71_G 94_Y 1.797 1.00
165_D 168_K 1.797 1.00
140_I 147_I 1.773 1.00
129_L 159_A 1.713 0.99
39_Y 106_V 1.666 0.99
129_L 155_M 1.653 0.99
140_I 155_M 1.638 0.99
77_K 86_W 1.625 0.99
34_F 121_L 1.505 0.98
42_T 63_T 1.505 0.98
71_G 92_K 1.503 0.98
149_D 153_Q 1.492 0.98
127_H 151_V 1.488 0.98
63_T 77_K 1.478 0.98
46_I 142_S 1.463 0.98
35_D 38_R 1.45 0.98
48_R 60_V 1.435 0.98
62_A 106_V 1.422 0.97
91_G 104_L 1.396 0.97
107_S 110_G 1.391 0.97
138_L 164_F 1.367 0.96
119_I 129_L 1.355 0.96
142_S 147_I 1.347 0.96
28_V 135_R 1.346 0.96
40_L 65_S 1.304 0.95
129_L 147_I 1.28 0.94
40_L 66_L 1.273 0.94
16_V 19_C 1.259 0.94
138_L 159_A 1.247 0.93
158_V 162_E 1.244 0.93
39_Y 62_A 1.218 0.92
53_F 137_Y 1.212 0.92
120_A 127_H 1.199 0.91
44_Y 172_V 1.199 0.91
64_Y 76_N 1.195 0.91
120_A 158_V 1.185 0.91
51_H 170_I 1.167 0.90
119_I 131_C 1.156 0.89
45_E 139_W 1.139 0.88
156_L 169_F 1.139 0.88
94_Y 113_Y 1.135 0.88
54_E 139_W 1.128 0.88
34_F 101_R 1.125 0.87
42_T 61_T 1.118 0.87
154_E 158_V 1.089 0.85
102_A 118_V 1.084 0.85
156_L 166_V 1.069 0.84
147_I 155_M 1.068 0.83
37_K 66_L 1.06 0.83
39_Y 76_N 1.056 0.82
155_M 158_V 1.049 0.82
102_A 119_I 1.041 0.81
80_N 87_Q 1.038 0.81
107_S 113_Y 1.03 0.80
120_A 155_M 1.027 0.80
15_L 19_C 1.024 0.80
107_S 112_F 1.022 0.80
6_L 10_A 1.018 0.79
39_Y 141_L 1.002 0.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1qwdA20.98871000.295Contact Map0.755
3ebwA20.85881000.365Contact Map0.549
2hzqA10.88141000.373Contact Map0.665
3fmzA20.97181000.375Contact Map0.481
1gkaB10.91531000.379Contact Map0.483
1kt6A10.88141000.381Contact Map0.417
1z24A10.89271000.382Contact Map0.373
1kxoA10.8871000.391Contact Map0.547
3cqnA20.89831000.397Contact Map0.412
1i4uA20.90961000.397Contact Map0.54

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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