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ATDA - Spermidine N(1)-acetyltransferase
UniProt: P0A951 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12447
Length: 186 (171)
Sequences: 9359
Seq/Len: 54.73

ATDA
Paralog alert: 0.84 [within 20: 0.16] - ratio of genomes with paralogs
Cluster includes: ATDA PHNO RIMI RIMJ RIML YAFP YEDL YHHY YIAC YJAB YJGM YNCA YPEA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
101_T 137_K 3.42 1.00
10_R 63_E 3.098 1.00
10_R 16_D 2.955 1.00
143_E 163_C 2.61 1.00
122_L 135_Y 2.577 1.00
142_V 145_E 2.569 1.00
133_H 136_R 2.37 1.00
142_V 160_I 2.21 1.00
6_S 102_R 2.189 1.00
109_D 113_T 2.091 1.00
84_A 117_L 2.005 1.00
108_M 120_L 2 1.00
124_V 132_I 1.907 1.00
74_L 111_G 1.9 1.00
61_V 68_K 1.873 1.00
12_L 61_V 1.832 1.00
136_R 142_V 1.817 1.00
4_A 106_L 1.812 1.00
4_A 102_R 1.796 1.00
124_V 135_Y 1.792 1.00
118_Y 148_H 1.786 1.00
132_I 160_I 1.746 1.00
148_H 167_H 1.744 1.00
108_M 140_F 1.725 1.00
69_A 94_Y 1.72 1.00
106_L 109_D 1.704 1.00
26_N 92_P 1.695 1.00
126_K 158_N 1.691 1.00
132_I 136_R 1.688 1.00
111_G 120_L 1.67 1.00
119_K 163_C 1.667 1.00
145_E 160_I 1.654 1.00
28_S 92_P 1.651 1.00
72_V 107_A 1.612 1.00
151_F 156_Y 1.557 1.00
119_K 143_E 1.536 1.00
90_I 100_A 1.511 1.00
86_F 104_A 1.508 1.00
18_R 41_F 1.488 1.00
108_M 164_I 1.482 1.00
132_I 162_M 1.458 1.00
132_I 142_V 1.447 1.00
67_E 93_E 1.439 1.00
72_V 103_A 1.435 1.00
19_Y 67_E 1.404 0.99
145_E 158_N 1.395 0.99
104_A 138_L 1.394 0.99
19_Y 68_K 1.391 0.99
101_T 134_I 1.382 0.99
101_T 138_L 1.349 0.99
112_F 166_Q 1.346 0.99
63_E 66_G 1.317 0.99
146_L 161_R 1.313 0.99
62_V 103_A 1.304 0.99
62_V 90_I 1.268 0.99
129_E 132_I 1.258 0.99
14_R 49_D 1.257 0.99
17_L 48_Y 1.238 0.98
110_Y 114_V 1.237 0.98
88_I 135_Y 1.229 0.98
91_S 94_Y 1.223 0.98
131_A 135_Y 1.206 0.98
71_L 89_I 1.189 0.98
126_K 160_I 1.176 0.98
127_E 157_R 1.169 0.97
88_I 131_A 1.165 0.97
126_K 145_E 1.156 0.97
4_A 7_V 1.152 0.97
148_H 158_N 1.147 0.97
118_Y 156_Y 1.138 0.97
18_R 22_Q 1.131 0.97
129_E 133_H 1.122 0.97
142_V 162_M 1.12 0.96
19_Y 22_Q 1.118 0.96
47_L 51_H 1.117 0.96
135_Y 140_F 1.114 0.96
8_K 63_E 1.097 0.96
29_V 95_Q 1.087 0.96
100_A 134_I 1.081 0.95
108_M 138_L 1.07 0.95
85_E 123_I 1.064 0.95
149_E 159_A 1.055 0.95
147_M 163_C 1.045 0.94
110_Y 115_L 1.037 0.94
105_K 138_L 1.031 0.94
60_F 110_Y 1.03 0.94
64_C 69_A 1.028 0.94
41_F 45_S 1.023 0.93
46_D 50_K 1.017 0.93
95_Q 130_K 1.008 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2vzyA40.98921000.315Contact Map0.768
3pzjA20.92471000.316Contact Map0.773
2z10A10.99461000.326Contact Map0.76
1yreA40.94091000.334Contact Map0.783
3tthA120.90861000.335Contact Map0.797
1nslA60.93011000.344Contact Map0.894
3r9fA20.89781000.346Contact Map0.773
3tcvA211000.357Contact Map0.815
4mhdA30.93551000.358Contact Map0.851
4mi4A30.93551000.358Contact Map0.855

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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