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FABB - 3-oxoacyl-[acyl-carrier-protein] synthase 1
UniProt: P0A953 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10274
Length: 406 (400)
Sequences: 10026
Seq/Len: 25.07

FABB
Paralog alert: 0.57 [within 20: 0.25] - ratio of genomes with paralogs
Cluster includes: FABB FABF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
18_N 21_E 3.421 1.00
224_A 366_E 3.35 1.00
98_R 183_D 3.306 1.00
255_A 347_L 3.27 1.00
346_S 385_V 3.034 1.00
24_A 28_E 2.981 1.00
278_V 315_E 2.963 1.00
85_D 254_Y 2.938 1.00
222_Y 297_S 2.848 1.00
258_V 402_R 2.789 1.00
82_A 239_V 2.642 1.00
242_E 245_H 2.554 1.00
170_I 343_A 2.51 1.00
384_T 402_R 2.398 1.00
349_M 356_A 2.332 1.00
60_I 68_M 2.309 1.00
171_G 260_Y 2.305 1.00
224_A 363_E 2.303 1.00
254_Y 351_E 2.243 1.00
102_I 176_Q 2.21 1.00
221_T 329_A 2.148 1.00
177_I 242_E 2.146 1.00
241_E 251_A 2.118 1.00
174_V 257_I 2.081 1.00
343_A 401_M 2.078 1.00
232_A 334_S 2.077 1.00
33_I 50_G 2.073 1.00
6_I 347_L 2.072 1.00
243_L 404_L 2.072 1.00
147_A 156_N 2.058 1.00
278_V 282_K 2.051 1.00
79_M 186_F 2.017 1.00
236_G 340_V 1.994 1.00
78_S 235_G 1.984 1.00
241_E 249_R 1.955 1.00
25_S 32_G 1.942 1.00
292_I 384_T 1.928 1.00
103_A 237_M 1.91 1.00
22_V 327_T 1.903 1.00
105_S 142_V 1.891 1.00
100_G 185_V 1.881 1.00
25_S 30_R 1.877 1.00
238_V 343_A 1.871 1.00
225_H 363_E 1.867 1.00
245_H 248_A 1.854 1.00
6_I 343_A 1.849 1.00
55_D 58_G 1.842 1.00
79_M 146_L 1.84 1.00
27_R 354_F 1.838 1.00
291_P 384_T 1.832 1.00
343_A 387_S 1.829 1.00
3_R 258_V 1.824 1.00
210_K 227_D 1.798 1.00
161_S 164_A 1.747 1.00
182_Q 185_V 1.745 1.00
176_Q 182_Q 1.742 1.00
17_N 21_E 1.736 1.00
383_T 403_K 1.733 1.00
80_E 84_A 1.732 1.00
85_D 252_H 1.722 1.00
186_F 239_V 1.707 1.00
348_L 352_H 1.707 1.00
327_T 341_Q 1.705 1.00
358_S 361_I 1.696 1.00
175_E 179_L 1.692 1.00
13_S 341_Q 1.685 1.00
243_L 247_L 1.67 1.00
223_D 361_I 1.669 1.00
223_D 362_E 1.668 1.00
35_F 47_H 1.64 1.00
225_H 362_E 1.628 1.00
214_T 217_K 1.601 1.00
294_Y 355_I 1.569 1.00
75_A 146_L 1.562 1.00
252_H 351_E 1.553 1.00
353_G 383_T 1.539 1.00
323_A 355_I 1.529 1.00
278_V 316_V 1.523 1.00
144_A 393_G 1.52 1.00
236_G 344_I 1.516 1.00
372_N 379_D 1.515 1.00
280_C 284_A 1.511 1.00
10_G 78_S 1.507 1.00
75_A 142_V 1.506 1.00
170_I 240_V 1.498 1.00
295_L 313_I 1.492 1.00
79_M 237_M 1.491 1.00
168_H 395_T 1.482 1.00
35_F 48_V 1.478 1.00
143_S 158_S 1.478 1.00
98_R 283_M 1.474 1.00
354_F 378_T 1.473 1.00
188_G 237_M 1.471 1.00
294_Y 325_S 1.465 1.00
331_T 341_Q 1.453 1.00
365_D 368_A 1.45 1.00
261_G 280_C 1.45 1.00
2_K 5_V 1.446 1.00
50_G 232_A 1.444 1.00
348_L 351_E 1.429 1.00
31_S 218_A 1.426 1.00
173_A 187_A 1.423 1.00
4_A 240_V 1.42 1.00
104_G 165_T 1.42 1.00
100_G 182_Q 1.42 1.00
329_A 359_I 1.419 1.00
9_L 19_Q 1.414 1.00
260_Y 399_L 1.392 0.99
70_D 74_Y 1.391 0.99
175_E 178_Q 1.39 0.99
78_S 237_M 1.388 0.99
261_G 284_A 1.378 0.99
168_H 397_A 1.374 0.99
353_G 403_K 1.372 0.99
238_V 340_V 1.357 0.99
22_V 345_Y 1.351 0.99
24_A 30_R 1.349 0.99
20_Q 85_D 1.347 0.99
208_S 220_R 1.344 0.99
170_I 399_L 1.342 0.99
83_I 150_F 1.327 0.99
82_A 237_M 1.321 0.99
100_G 155_V 1.321 0.99
310_L 324_I 1.314 0.99
184_I 239_V 1.314 0.99
31_S 360_N 1.301 0.99
258_V 384_T 1.298 0.99
2_K 244_E 1.293 0.99
175_E 181_K 1.292 0.99
157_Y 172_N 1.291 0.99
21_E 24_A 1.283 0.99
89_S 92_A 1.278 0.99
254_Y 347_L 1.276 0.99
388_N 398_T 1.272 0.99
95_N 151_K 1.264 0.99
8_G 85_D 1.259 0.99
355_I 374_V 1.253 0.99
208_S 227_D 1.253 0.99
294_Y 346_S 1.252 0.99
292_I 400_V 1.239 0.98
13_S 236_G 1.237 0.98
263_T 396_N 1.236 0.98
80_E 149_P 1.234 0.98
330_M 359_I 1.227 0.98
2_K 242_E 1.226 0.98
329_A 358_S 1.213 0.98
9_L 344_I 1.207 0.98
223_D 363_E 1.204 0.98
75_A 103_A 1.204 0.98
173_A 185_V 1.203 0.98
153_H 279_R 1.199 0.98
209_T 227_D 1.196 0.98
271_A 304_V 1.194 0.98
40_K 43_G 1.193 0.98
350_L 401_M 1.191 0.98
175_E 287_G 1.191 0.98
103_A 188_G 1.186 0.98
220_R 225_H 1.186 0.98
282_K 286_H 1.18 0.98
310_L 373_I 1.173 0.98
216_E 227_D 1.172 0.98
4_A 174_V 1.17 0.97
386_M 398_T 1.17 0.97
279_R 283_M 1.169 0.97
238_V 344_I 1.164 0.97
183_D 242_E 1.161 0.97
147_A 264_S 1.157 0.97
176_Q 181_K 1.157 0.97
259_G 287_G 1.157 0.97
24_A 27_R 1.157 0.97
317_F 386_M 1.154 0.97
281_M 316_V 1.147 0.97
313_I 324_I 1.147 0.97
263_T 280_C 1.142 0.97
217_K 362_E 1.142 0.97
174_V 178_Q 1.141 0.97
99_V 184_I 1.139 0.97
386_M 400_V 1.136 0.97
83_I 239_V 1.134 0.97
285_M 292_I 1.131 0.97
334_S 341_Q 1.13 0.97
110_P 117_A 1.112 0.96
299_G 305_G 1.111 0.96
11_I 19_Q 1.11 0.96
75_A 237_M 1.109 0.96
357_P 378_T 1.107 0.96
292_I 317_F 1.106 0.96
45_R 202_D 1.1 0.96
243_L 256_E 1.091 0.96
210_K 216_E 1.087 0.96
327_T 331_T 1.085 0.96
350_L 382_L 1.078 0.95
346_S 350_L 1.077 0.95
170_I 187_A 1.074 0.95
299_G 326_A 1.073 0.95
234_G 334_S 1.072 0.95
281_M 388_N 1.071 0.95
20_Q 24_A 1.063 0.95
174_V 287_G 1.061 0.95
373_I 376_E 1.056 0.95
199_C 231_I 1.056 0.95
11_I 22_V 1.054 0.95
18_N 81_Q 1.054 0.95
375_T 379_D 1.054 0.95
156_N 264_S 1.054 0.95
244_E 247_L 1.051 0.94
231_I 335_L 1.05 0.94
293_D 383_T 1.048 0.94
168_H 262_A 1.048 0.94
283_M 287_G 1.038 0.94
159_I 172_N 1.03 0.94
153_H 275_E 1.026 0.94
220_R 227_D 1.022 0.93
27_R 378_T 1.019 0.93
15_I 32_G 1.019 0.93
361_I 364_L 1.018 0.93
33_I 48_V 1.016 0.93
23_L 352_H 1.014 0.93
6_I 401_M 1.01 0.93
177_I 245_H 1.01 0.93
26_L 348_L 1.01 0.93
171_G 181_K 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2vz8A20.95321000.007Contact Map0.763
3mqdA10.99011000.101Contact Map0.785
4kc5A40.96061000.107Contact Map0.841
2gqdA20.98771000.107Contact Map0.744
4jrmD40.98521000.109Contact Map0.781
3o04A10.98771000.109Contact Map0.754
1e5mA10.98771000.11Contact Map0.765
4jgaA20.99261000.111Contact Map0.8
2hg4A60.95811000.112Contact Map0.82
1ox0A10.98521000.114Contact Map0.753

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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