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ALKH - KHG/KDPG aldolase
UniProt: P0A955 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10256
Length: 213 (202)
Sequences: 1542
Seq/Len: 7.63

ALKH
Paralog alert: 0.43 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: ALKH DGOA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
61_A 89_Q 3.507 1.00
196_D 199_R 2.797 1.00
55_D 58_R 2.364 1.00
202_K 206_E 2.323 1.00
35_A 39_G 2.28 1.00
97_T 126_D 2.207 1.00
34_K 63_E 2.127 1.00
201_T 205_R 2.117 1.00
98_E 123_L 2.061 1.00
33_A 60_I 1.984 1.00
76_N 79_Q 1.978 1.00
48_L 54_V 1.938 1.00
84_T 109_I 1.924 1.00
25_K 28_H 1.903 1.00
101_L 111_L 1.902 1.00
124_G 132_F 1.888 1.00
170_R 174_A 1.878 1.00
28_H 195_G 1.875 1.00
38_A 201_T 1.86 1.00
58_R 62_K 1.852 1.00
54_V 82_E 1.834 1.00
79_Q 82_E 1.825 1.00
81_A 85_E 1.793 1.00
81_A 103_A 1.783 1.00
117_T 120_E 1.76 1.00
18_V 159_C 1.751 1.00
96_L 127_Y 1.741 1.00
78_Q 82_E 1.695 1.00
140_N 145_A 1.689 1.00
115_I 121_L 1.668 1.00
21_I 44_L 1.643 1.00
57_I 71_A 1.616 1.00
92_I 112_I 1.613 1.00
102_K 127_Y 1.608 1.00
125_M 155_Q 1.601 1.00
199_R 202_K 1.593 1.00
121_L 156_V 1.566 1.00
105_T 130_K 1.559 1.00
26_L 52_C 1.549 1.00
125_M 156_V 1.531 1.00
115_I 132_F 1.521 1.00
145_A 149_I 1.511 0.99
99_P 126_D 1.503 0.99
46_V 60_I 1.481 0.99
74_V 91_A 1.439 0.99
134_F 140_N 1.407 0.99
37_V 64_V 1.406 0.99
103_A 107_G 1.404 0.99
30_V 59_A 1.383 0.99
55_D 59_A 1.381 0.99
104_A 111_L 1.36 0.99
182_G 185_W 1.357 0.99
37_V 67_A 1.339 0.98
96_L 101_L 1.339 0.98
93_S 111_L 1.336 0.98
81_A 107_G 1.33 0.98
52_C 55_D 1.329 0.98
30_V 63_E 1.327 0.98
96_L 115_I 1.319 0.98
191_A 199_R 1.302 0.98
80_L 100_L 1.267 0.98
118_V 149_I 1.263 0.98
116_S 140_N 1.259 0.98
121_L 153_F 1.241 0.97
134_F 158_F 1.232 0.97
48_L 83_V 1.207 0.97
30_V 64_V 1.194 0.96
34_K 38_A 1.19 0.96
93_S 113_P 1.182 0.96
70_G 90_F 1.182 0.96
122_M 153_F 1.18 0.96
95_G 122_M 1.165 0.96
37_V 42_R 1.157 0.95
160_P 177_S 1.154 0.95
91_A 104_A 1.152 0.95
91_A 109_I 1.149 0.95
138_E 144_K 1.149 0.95
146_L 177_S 1.145 0.95
180_C 185_W 1.141 0.95
119_S 123_L 1.14 0.95
200_I 204_A 1.129 0.94
199_R 203_L 1.11 0.94
98_E 102_K 1.108 0.94
165_S 168_N 1.101 0.93
137_A 164_I 1.098 0.93
59_A 63_E 1.089 0.93
138_E 172_Y 1.074 0.92
99_P 102_K 1.072 0.92
34_K 64_V 1.068 0.92
49_R 161_T 1.057 0.92
80_L 103_A 1.055 0.91
139_A 145_A 1.051 0.91
83_V 88_A 1.047 0.91
30_V 60_I 1.041 0.91
80_L 91_A 1.036 0.90
71_A 83_V 1.028 0.90
106_E 126_D 1.022 0.90
205_R 209_E 1.021 0.90
160_P 178_V 1.019 0.89
80_L 104_A 1.018 0.89
26_L 56_A 1.007 0.89
20_V 161_T 1.006 0.89
116_S 149_I 1.005 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1vhcA611000.46Contact Map0.803
1wbhA311000.467Contact Map0.765
4e38A311000.472Contact Map0.796
3labA20.98121000.475Contact Map0.681
1mxsA111000.481Contact Map0.688
2yw3A60.95311000.501Contact Map0.702
1wa3A60.94371000.552Contact Map0.82
2v82A10.9391000.603Contact Map0.643
1w8sA100.962499.90.655Contact Map0.371
3ajxA40.877999.90.684Contact Map0.524

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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