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ALAA - Glutamate-pyruvate aminotransferase AlaA
UniProt: P0A959 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14101
Length: 405 (395)
Sequences: 19363
Seq/Len: 49.02

ALAA
Paralog alert: 0.94 [within 20: 0.26] - ratio of genomes with paralogs
Cluster includes: AAT ALAA ALAC ARNB AVTA CSDA HIS8 ISCS MALY RFFA SERC SUFS TYRB YBDL YDCR YJIR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
59_I 63_P 3.138 1.00
308_E 385_V 3.123 1.00
162_R 199_Q 3.11 1.00
359_E 397_R 3.009 1.00
307_Y 311_N 2.878 1.00
187_K 191_M 2.862 1.00
101_G 107_L 2.856 1.00
312_R 389_E 2.847 1.00
121_E 142_K 2.791 1.00
52_D 56_V 2.641 1.00
390_L 394_K 2.598 1.00
354_D 358_Q 2.571 1.00
80_A 291_G 2.564 1.00
324_S 337_K 2.558 1.00
86_Q 92_D 2.478 1.00
120_D 170_R 2.431 1.00
116_L 141_G 2.413 1.00
390_L 393_S 2.358 1.00
56_V 60_R 2.267 1.00
316_L 392_L 2.259 1.00
76_S 287_Q 2.247 1.00
186_S 189_L 2.204 1.00
191_M 195_E 2.203 1.00
249_Q 286_I 2.137 1.00
79_K 83_Q 2.074 1.00
109_V 113_Q 2.067 1.00
79_K 95_V 1.948 1.00
159_D 192_E 1.938 1.00
38_L 391_S 1.922 1.00
315_E 319_D 1.914 1.00
311_N 315_E 1.901 1.00
171_G 205_F 1.869 1.00
121_E 144_V 1.868 1.00
188_E 191_M 1.867 1.00
312_R 385_V 1.865 1.00
197_A 204_I 1.84 1.00
314_W 318_N 1.832 1.00
316_L 319_D 1.827 1.00
162_R 192_E 1.808 1.00
136_V 141_G 1.803 1.00
205_F 235_F 1.785 1.00
149_D 189_L 1.784 1.00
316_L 393_S 1.77 1.00
104_V 235_F 1.765 1.00
75_Y 79_K 1.753 1.00
209_I 237_G 1.753 1.00
314_W 327_K 1.747 1.00
83_Q 291_G 1.744 1.00
111_A 205_F 1.738 1.00
347_D 350_K 1.726 1.00
157_D 160_D 1.722 1.00
192_E 195_E 1.708 1.00
80_A 83_Q 1.697 1.00
384_R 387_D 1.697 1.00
126_A 145_H 1.694 1.00
82_M 95_V 1.689 1.00
198_R 229_D 1.687 1.00
318_N 325_C 1.677 1.00
316_L 396_A 1.675 1.00
155_F 189_L 1.666 1.00
160_D 164_K 1.657 1.00
363_L 377_F 1.657 1.00
393_S 397_R 1.646 1.00
121_E 166_T 1.638 1.00
81_I 251_W 1.633 1.00
312_R 316_L 1.613 1.00
160_D 163_A 1.582 1.00
8_S 117_N 1.57 1.00
111_A 233_I 1.568 1.00
76_S 291_G 1.561 1.00
55_L 59_I 1.538 1.00
60_R 288_T 1.537 1.00
122_M 136_V 1.537 1.00
201_N 231_L 1.526 1.00
81_I 100_I 1.524 1.00
165_I 196_I 1.513 1.00
133_T 137_S 1.512 1.00
121_E 169_T 1.503 1.00
354_D 398_F 1.499 1.00
187_K 221_H 1.497 1.00
279_N 282_A 1.495 1.00
158_L 196_I 1.494 1.00
319_D 396_A 1.492 1.00
300_I 304_G 1.491 1.00
385_V 389_E 1.484 1.00
162_R 200_H 1.48 1.00
85_Y 253_V 1.473 1.00
112_M 173_V 1.461 1.00
195_E 199_Q 1.46 1.00
313_A 392_L 1.458 1.00
197_A 202_L 1.455 1.00
74_L 284_H 1.452 1.00
396_A 400_S 1.447 1.00
316_L 389_E 1.445 1.00
121_E 168_R 1.443 1.00
82_M 98_I 1.438 1.00
195_E 198_R 1.425 1.00
174_I 193_I 1.418 1.00
57_D 288_T 1.41 1.00
80_A 287_Q 1.409 1.00
187_K 226_L 1.397 0.99
252_M 268_L 1.391 0.99
93_V 253_V 1.387 0.99
300_I 303_G 1.384 0.99
112_M 136_V 1.363 0.99
33_N 360_K 1.361 0.99
60_R 64_T 1.354 0.99
313_A 334_M 1.348 0.99
359_E 394_K 1.345 0.99
56_V 59_I 1.342 0.99
353_L 357_L 1.34 0.99
126_A 147_L 1.334 0.99
81_I 98_I 1.329 0.99
254_L 265_I 1.328 0.99
83_Q 87_A 1.324 0.99
78_R 82_M 1.321 0.99
189_L 192_E 1.321 0.99
52_D 55_L 1.318 0.99
350_K 354_D 1.314 0.99
112_M 116_L 1.305 0.99
87_A 294_Q 1.294 0.99
116_L 122_M 1.292 0.99
318_N 327_K 1.29 0.99
158_L 192_E 1.29 0.99
389_E 393_S 1.287 0.99
196_I 200_H 1.268 0.99
72_K 78_R 1.266 0.99
147_L 160_D 1.266 0.99
314_W 325_C 1.264 0.99
305_R 385_V 1.259 0.99
55_L 63_P 1.255 0.99
238_L 286_I 1.255 0.99
122_M 171_G 1.253 0.99
267_G 270_M 1.251 0.99
233_I 252_M 1.249 0.99
227_A 230_L 1.246 0.98
124_V 143_A 1.243 0.98
162_R 196_I 1.241 0.98
314_W 334_M 1.234 0.98
115_L 203_I 1.225 0.98
304_G 307_Y 1.221 0.98
379_I 391_S 1.218 0.98
310_R 314_W 1.216 0.98
313_A 388_I 1.214 0.98
188_E 192_E 1.212 0.98
113_Q 139_S 1.207 0.98
85_Y 251_W 1.204 0.98
305_R 308_E 1.199 0.98
196_I 202_L 1.198 0.98
99_Y 265_I 1.197 0.98
348_D 367_T 1.196 0.98
96_E 258_K 1.195 0.98
172_I 202_L 1.181 0.98
335_F 366_G 1.178 0.98
187_K 225_P 1.176 0.98
133_T 145_H 1.173 0.98
58_V 285_A 1.172 0.98
315_E 318_N 1.172 0.98
149_D 157_D 1.171 0.98
236_N 251_W 1.17 0.97
166_T 169_T 1.163 0.97
76_S 284_H 1.16 0.97
72_K 269_E 1.154 0.97
123_L 169_T 1.152 0.97
204_I 223_I 1.144 0.97
287_Q 291_G 1.135 0.97
102_N 106_E 1.132 0.97
162_R 166_T 1.128 0.97
257_P 263_G 1.122 0.97
165_I 202_L 1.12 0.96
304_G 308_E 1.118 0.96
359_E 401_G 1.115 0.96
77_A 100_I 1.113 0.96
159_D 163_A 1.111 0.96
57_D 61_N 1.11 0.96
115_L 171_G 1.109 0.96
347_D 374_P 1.106 0.96
313_A 316_L 1.104 0.96
352_V 363_L 1.102 0.96
288_T 291_G 1.1 0.96
316_L 320_I 1.099 0.96
311_N 327_K 1.088 0.96
216_D 329_R 1.086 0.96
191_M 226_L 1.086 0.96
94_T 97_D 1.083 0.96
90_M 93_V 1.081 0.95
76_S 79_K 1.08 0.95
107_L 252_M 1.08 0.95
82_M 94_T 1.079 0.95
38_L 388_I 1.073 0.95
266_E 270_M 1.073 0.95
288_T 292_G 1.065 0.95
58_V 62_L 1.064 0.95
75_Y 95_V 1.059 0.95
224_A 234_T 1.056 0.95
56_V 63_P 1.053 0.95
98_I 253_V 1.05 0.94
27_R 31_E 1.045 0.94
107_L 235_F 1.044 0.94
118_S 140_S 1.039 0.94
94_T 258_K 1.034 0.94
136_V 143_A 1.033 0.94
310_R 381_T 1.033 0.94
337_K 376_H 1.032 0.94
44_A 47_G 1.032 0.94
165_I 169_T 1.029 0.94
43_P 306_L 1.028 0.94
383_P 387_D 1.027 0.94
355_F 358_Q 1.023 0.93
116_L 120_D 1.017 0.93
249_Q 278_A 1.012 0.93
361_V 395_F 1.012 0.93
117_N 120_D 1.01 0.93
128_D 175_I 1.002 0.92
102_N 279_N 1.001 0.92
194_V 204_I 1.001 0.92
123_L 146_Y 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3dydA20.98271000.297Contact Map0.789
2x5dA40.96541000.304Contact Map0.76
1xi9A40.96791000.307Contact Map0.786
1j32A20.94321000.31Contact Map0.777
3h14A10.93831000.314Contact Map0.631
2gb3A60.95311000.318Contact Map0.789
3jtxA20.92591000.322Contact Map0.729
2r2nA40.94571000.323Contact Map0.715
3fvsA20.94811000.323Contact Map0.706
4je5A30.95561000.324Contact Map0.711

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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