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ASPG1 - L-asparaginase 1
UniProt: P0A962 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10045
Length: 338 (334)
Sequences: 1655
Seq/Len: 4.96

ASPG1
Paralog alert: 0.36 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: ASPG1 ASPG2
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
101_L 114_V 3.985 1.00
5_S 48_D 3.684 1.00
216_T 240_R 3.655 1.00
97_T 114_V 3.614 1.00
149_L 161_T 3.563 1.00
144_I 187_I 3.535 1.00
227_R 259_E 3.445 1.00
105_L 112_V 3.145 1.00
52_H 74_D 2.943 1.00
9_A 54_Y 2.631 1.00
318_D 321_T 2.59 1.00
75_I 87_I 2.513 1.00
227_R 256_E 2.478 1.00
312_L 325_A 2.39 1.00
236_A 309_L 2.386 1.00
321_T 324_K 2.359 1.00
10_Y 16_G 2.311 1.00
230_L 260_A 2.287 1.00
150_F 155_L 2.28 1.00
7_Y 82_Y 2.255 1.00
258_Q 262_D 2.236 1.00
65_P 220_G 2.183 1.00
50_T 82_Y 2.084 1.00
5_S 50_T 2.083 1.00
86_V 139_A 2.08 1.00
156_Y 174_S 1.983 1.00
213_G 234_V 1.961 1.00
240_R 302_V 1.947 1.00
270_L 297_G 1.944 1.00
115_T 151_F 1.916 1.00
268_V 326_M 1.898 1.00
156_Y 161_T 1.866 1.00
269_N 294_V 1.791 1.00
266_V 295_I 1.753 1.00
68_W 219_P 1.741 1.00
9_A 52_H 1.737 1.00
79_Y 85_F 1.727 1.00
164_A 171_A 1.726 1.00
94_M 149_L 1.702 1.00
102_S 159_N 1.699 1.00
68_W 307_T 1.698 1.00
228_N 232_Q 1.678 0.99
138_V 155_L 1.666 0.99
54_Y 74_D 1.625 0.99
268_V 297_G 1.622 0.99
155_L 181_L 1.621 0.99
268_V 309_L 1.615 0.99
225_V 229_F 1.58 0.99
62_D 249_Q 1.564 0.99
241_S 269_N 1.536 0.99
78_H 81_D 1.532 0.99
144_I 148_T 1.522 0.99
79_Y 110_K 1.505 0.99
223_A 227_R 1.499 0.98
55_T 67_D 1.498 0.98
166_A 271_T 1.49 0.98
211_P 234_V 1.468 0.98
319_T 323_R 1.457 0.98
133_L 137_Y 1.455 0.98
164_A 173_A 1.437 0.98
223_A 256_E 1.432 0.98
226_V 260_A 1.431 0.98
227_R 231_R 1.421 0.98
100_A 104_M 1.409 0.97
270_L 302_V 1.404 0.97
9_A 74_D 1.401 0.97
79_Y 108_L 1.399 0.97
230_L 265_I 1.399 0.97
209_P 235_K 1.392 0.97
146_E 157_R 1.39 0.97
72_A 104_M 1.377 0.97
63_M 67_D 1.375 0.97
134_N 153_N 1.371 0.97
69_Q 104_M 1.37 0.97
65_P 310_H 1.368 0.97
71_I 87_I 1.367 0.97
211_P 224_D 1.349 0.96
324_K 328_Q 1.336 0.96
29_G 121_L 1.335 0.96
31_L 51_I 1.331 0.96
57_L 67_D 1.326 0.96
211_P 235_K 1.326 0.96
226_V 256_E 1.322 0.96
89_H 97_T 1.318 0.96
312_L 322_I 1.317 0.96
266_V 322_I 1.316 0.96
165_H 275_S 1.311 0.96
126_S 129_Q 1.309 0.96
217_I 248_P 1.278 0.95
75_I 85_F 1.274 0.95
85_F 110_K 1.272 0.95
7_Y 78_H 1.256 0.94
134_N 150_F 1.249 0.94
214_V 302_V 1.241 0.94
57_L 63_M 1.237 0.94
74_D 77_A 1.235 0.93
237_L 260_A 1.232 0.93
323_R 327_S 1.212 0.93
116_G 151_F 1.204 0.92
319_T 322_I 1.203 0.92
12_G 15_I 1.193 0.92
81_D 110_K 1.191 0.92
312_L 316_E 1.179 0.91
211_P 222_S 1.176 0.91
216_T 302_V 1.166 0.91
259_E 263_R 1.157 0.90
8_V 132_L 1.146 0.90
75_I 112_V 1.143 0.89
73_E 206_P 1.142 0.89
64_T 67_D 1.139 0.89
226_V 253_F 1.136 0.89
86_V 140_A 1.133 0.89
96_Y 272_Q 1.132 0.89
154_R 179_P 1.128 0.89
255_Q 258_Q 1.127 0.89
94_M 116_G 1.115 0.88
95_A 303_E 1.113 0.88
331_R 334_L 1.11 0.87
160_R 299_D 1.109 0.87
55_T 71_I 1.106 0.87
39_P 133_L 1.097 0.87
84_G 111_P 1.086 0.86
215_V 229_F 1.076 0.85
238_I 268_V 1.068 0.85
68_W 100_A 1.066 0.84
256_E 259_E 1.061 0.84
261_S 292_A 1.058 0.84
61_S 246_N 1.054 0.84
20_S 25_I 1.053 0.83
91_T 163_K 1.051 0.83
261_S 267_V 1.046 0.83
11_T 14_T 1.041 0.83
156_Y 179_P 1.036 0.82
99_S 103_F 1.032 0.82
215_V 226_V 1.03 0.82
93_T 242_Y 1.03 0.82
92_D 243_G 1.028 0.81
138_V 150_F 1.027 0.81
257_L 294_V 1.023 0.81
17_M 26_P 1.021 0.81
65_P 68_W 1.018 0.81
224_D 256_E 1.015 0.80
11_T 89_H 1.01 0.80
41_F 136_L 1.005 0.79
10_Y 53_E 1.005 0.79
102_S 158_G 1.002 0.79
141_N 144_I 1.001 0.79
75_I 97_T 1 0.79
86_V 136_L 1 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2himA411000.015Contact Map0.823
1wlsA20.96451000.049Contact Map0.847
1zq1A20.97931000.053Contact Map0.855
2d6fA20.97631000.057Contact Map0.83
1wsaA20.94671000.089Contact Map0.809
2wltA10.94381000.089Contact Map0.716
1nnsA20.94081000.093Contact Map0.731
3nxkA80.94081000.096Contact Map0.835
4pgaA20.94381000.096Contact Map0.789
1agxA10.93791000.1Contact Map0.685

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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