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CHEW - Chemotaxis protein CheW
UniProt: P0A964 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10149
Length: 167 (150)
Sequences: 2407
Seq/Len: 16.05

CHEW
Paralog alert: 0.58 [within 20: 0.15] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
28_E 140_R 3.516 1.00
117_R 136_A 3.46 1.00
88_V 99_G 2.941 1.00
56_K 70_D 2.517 1.00
72_R 103_D 2.393 1.00
116_I 133_G 2.387 1.00
111_L 135_G 2.319 1.00
35_K 148_E 2.3 1.00
38_E 62_R 2.284 1.00
56_K 101_V 2.209 1.00
56_K 73_I 2.209 1.00
112_T 115_Q 2.058 1.00
68_I 88_V 1.995 1.00
18_E 110_S 1.87 1.00
91_L 100_I 1.84 1.00
37_Q 92_N 1.804 1.00
42_Y 45_V 1.794 1.00
80_V 83_N 1.748 1.00
41_G 87_V 1.613 1.00
137_L 140_R 1.534 1.00
22_F 89_I 1.512 1.00
132_T 146_N 1.507 1.00
146_N 149_K 1.484 1.00
60_N 65_I 1.461 1.00
131_L 143_I 1.423 1.00
71_L 150_L 1.407 0.99
42_Y 101_V 1.405 0.99
155_E 159_L 1.385 0.99
86_T 101_V 1.384 0.99
102_V 105_V 1.364 0.99
23_T 104_G 1.344 0.99
129_E 149_K 1.339 0.99
73_I 79_D 1.317 0.99
29_Y 127_S 1.315 0.99
53_A 73_I 1.309 0.99
83_N 86_T 1.307 0.99
17_Q 32_D 1.301 0.99
82_Y 86_T 1.288 0.99
68_I 99_G 1.265 0.99
133_G 144_L 1.246 0.98
59_T 68_I 1.221 0.98
66_V 97_V 1.215 0.98
20_L 87_V 1.207 0.98
23_T 26_D 1.205 0.98
60_N 63_G 1.201 0.98
134_L 141_M 1.2 0.98
27_E 131_L 1.195 0.98
19_F 135_G 1.193 0.98
40_R 61_L 1.169 0.97
24_L 42_Y 1.163 0.97
91_L 150_L 1.141 0.97
30_G 144_L 1.124 0.97
45_V 68_I 1.121 0.97
152_N 155_E 1.099 0.96
70_D 80_V 1.082 0.96
40_R 43_D 1.081 0.95
157_A 161_S 1.08 0.95
28_E 106_S 1.071 0.95
56_K 82_Y 1.061 0.95
115_Q 137_L 1.045 0.94
19_F 144_L 1.035 0.94
92_N 97_V 1.021 0.93
37_Q 64_V 1.012 0.93
22_F 38_E 1.009 0.93
33_I 40_R 1.008 0.93
40_R 105_V 1.006 0.93
21_V 28_E 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ho9A111000.23Contact Map0.618
2qdlA20.96411000.312Contact Map0.803
4jpbW10.88021000.323Contact Map0.711
3ur1B10.83231000.333Contact Map0.605
1b3qA20.844399.50.65Contact Map0.54
2b29A10.68265.90.946Contact Map0.263
4ipcA10.68264.70.948Contact Map0.256
1wi9A10.41924.30.949Contact Map0.121
2igpA10.38922.10.957Contact Map0.037
3g3oA10.4911.80.958Contact Map0.029

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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