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CSPE - Cold shock-like protein CspE
UniProt: P0A972 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12179
Length: 69 (67)
Sequences: 3006
Seq/Len: 44.87

CSPE
Paralog alert: 0.77 [within 20: 0.16] - ratio of genomes with paralogs
Cluster includes: CSPA CSPB CSPC CSPD CSPE CSPF CSPG CSPH CSPI
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
31_V 66_V 3.883 1.00
55_T 64_A 3.824 1.00
53_E 65_N 2.708 1.00
48_Q 68_A 2.369 1.00
7_N 49_R 2.311 1.00
23_E 49_R 2.219 1.00
13_E 45_A 2.104 1.00
5_K 51_E 2.074 1.00
51_E 69_L 1.853 1.00
51_E 67_I 1.85 1.00
35_A 64_A 1.836 1.00
5_K 49_R 1.775 1.00
37_Q 65_N 1.747 1.00
56_N 61_P 1.729 1.00
22_P 52_F 1.667 1.00
63_A 66_V 1.662 1.00
22_P 25_G 1.608 1.00
4_I 22_P 1.582 1.00
22_P 26_S 1.57 1.00
57_G 62_S 1.488 1.00
31_V 44_L 1.462 1.00
49_R 69_L 1.439 1.00
37_Q 67_I 1.372 0.99
13_E 43_T 1.302 0.99
33_F 36_I 1.276 0.99
11_F 33_F 1.258 0.99
5_K 23_E 1.222 0.98
22_P 27_K 1.186 0.98
45_A 48_Q 1.175 0.98
13_E 41_F 1.173 0.98
7_N 21_T 1.156 0.97
38_T 68_A 1.129 0.97
33_F 42_K 1.113 0.96
35_A 55_T 1.067 0.95
29_V 54_I 1.032 0.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3i2zB2199.90.097Contact Map0.902
3camA20.97199.90.099Contact Map0.851
1c9oA20.956599.90.119Contact Map0.863
2lxjA10.956599.90.122Contact Map0.538
2lssA1199.90.126Contact Map0.593
3a0jA20.956599.80.135Contact Map0.818
1g6pA10.94299.80.141Contact Map0.488
3uljA2199.80.142Contact Map0.778
1h95A1199.80.142Contact Map0.559
3ts2A2199.80.15Contact Map0.771

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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