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CSPH - Cold shock-like protein CspH
UniProt: P0A982 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14281
Length: 70 (67)
Sequences: 2967
Seq/Len: 44.28

CSPH
Paralog alert: 0.78 [within 20: 0.16] - ratio of genomes with paralogs
Cluster includes: CSPA CSPB CSPC CSPD CSPE CSPF CSPG CSPH CSPI
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
56_V 65_A 3.952 1.00
32_V 67_V 3.855 1.00
54_C 66_N 2.825 1.00
49_L 69_L 2.386 1.00
8_I 50_R 2.34 1.00
24_S 50_R 2.22 1.00
52_E 68_Y 2.182 1.00
14_R 46_I 2.117 1.00
6_T 52_E 2.054 1.00
38_T 66_N 1.87 1.00
6_T 50_R 1.814 1.00
57_N 62_P 1.812 1.00
36_A 65_A 1.788 1.00
23_P 53_F 1.709 1.00
58_G 63_T 1.694 1.00
52_E 70_S 1.653 1.00
23_P 26_G 1.622 1.00
64_A 67_V 1.568 1.00
23_P 27_R 1.491 1.00
32_V 45_L 1.468 1.00
38_T 68_Y 1.34 0.99
14_R 44_V 1.325 0.99
12_F 34_I 1.294 0.99
55_R 62_P 1.276 0.99
34_I 37_F 1.265 0.99
6_T 24_S 1.237 0.98
46_I 49_L 1.234 0.98
28_K 62_P 1.231 0.98
14_R 42_A 1.185 0.98
39_P 69_L 1.169 0.97
5_M 23_P 1.16 0.97
8_I 22_I 1.138 0.97
34_I 43_E 1.112 0.96
50_R 70_S 1.108 0.96
30_V 55_R 1.044 0.94
58_G 61_G 1.021 0.93
37_F 43_E 1.014 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2lssA1199.90.099Contact Map0.609
3i2zB2199.90.111Contact Map0.921
3camA20.957199.90.115Contact Map0.874
1h95A1199.90.13Contact Map0.549
1c9oA20.942999.80.135Contact Map0.864
1g6pA10.928699.80.142Contact Map0.51
2lxjA10.942999.80.142Contact Map0.541
2kcmA10.928699.80.149Contact Map0.51
3a0jA20.942999.80.156Contact Map0.828
3uljA20.971499.80.157Contact Map0.81

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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