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CSPI - Cold shock-like protein CspI
UniProt: P0A986 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13877
Length: 70 (67)
Sequences: 3000
Seq/Len: 44.78

CSPI
Paralog alert: 0.78 [within 20: 0.16] - ratio of genomes with paralogs
Cluster includes: CSPA CSPB CSPC CSPD CSPE CSPF CSPG CSPH CSPI
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
32_V 67_V 3.951 1.00
56_E 65_V 3.715 1.00
54_G 66_H 2.707 1.00
49_Q 69_A 2.458 1.00
8_L 50_E 2.291 1.00
24_K 50_E 2.227 1.00
14_P 46_T 2.129 1.00
6_T 52_E 2.075 1.00
52_E 68_V 1.955 1.00
38_Q 66_H 1.869 1.00
57_N 62_P 1.856 1.00
52_E 70_L 1.835 1.00
36_A 65_V 1.828 1.00
6_T 50_E 1.767 1.00
64_A 67_V 1.685 1.00
23_P 53_F 1.658 1.00
58_G 63_A 1.588 1.00
23_P 27_S 1.554 1.00
23_P 26_G 1.542 1.00
50_E 70_L 1.541 1.00
5_M 23_P 1.539 1.00
32_V 45_L 1.474 1.00
14_P 44_T 1.378 0.99
38_Q 68_V 1.376 0.99
23_P 28_K 1.292 0.99
12_F 34_F 1.284 0.99
34_F 37_I 1.251 0.99
6_T 24_K 1.22 0.98
39_S 69_A 1.212 0.98
46_T 49_Q 1.208 0.98
14_P 42_F 1.189 0.98
8_L 22_T 1.165 0.97
34_F 43_K 1.081 0.95
36_A 56_E 1.032 0.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2lssA1199.90.105Contact Map0.588
3camA20.957199.90.116Contact Map0.853
3i2zB2199.90.12Contact Map0.899
1h95A1199.90.132Contact Map0.555
2lxjA10.942999.90.136Contact Map0.523
1c9oA20.942999.90.136Contact Map0.859
3a0jA20.942999.80.151Contact Map0.817
1g6pA10.928699.80.153Contact Map0.478
2kcmA10.928699.80.16Contact Map0.502
3uljA20.971499.80.167Contact Map0.779

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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