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FTNA - Ferritin-1
UniProt: P0A998 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10921
Length: 165 (162)
Sequences: 1286
Seq/Len: 7.94

FTNA
Paralog alert: 0.39 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: FTNA FTNB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
88_Q 142_S 3.273 1.00
84_D 138_I 2.707 1.00
16_L 100_K 2.44 1.00
39_A 83_L 2.405 1.00
106_H 112_Q 2.174 1.00
14_M 61_L 2.001 1.00
81_S 85_E 1.99 1.00
9_K 107_A 1.974 1.00
61_L 66_N 1.866 1.00
31_C 86_L 1.852 1.00
3_K 111_N 1.726 1.00
7_I 66_N 1.719 1.00
109_M 117_F 1.705 1.00
99_Q 103_E 1.664 1.00
91_Y 95_Q 1.645 1.00
10_L 116_T 1.645 1.00
118_N 125_S 1.63 1.00
5_E 111_N 1.618 1.00
82_S 85_E 1.598 1.00
84_D 142_S 1.551 1.00
44_R 59_D 1.525 1.00
10_L 57_L 1.524 1.00
43_L 90_T 1.521 1.00
31_C 43_L 1.506 1.00
96_L 100_K 1.498 1.00
87_F 141_L 1.489 0.99
106_H 110_T 1.485 0.99
89_E 92_K 1.468 0.99
4_P 8_E 1.462 0.99
22_L 70_I 1.459 0.99
63_D 132_K 1.441 0.99
10_L 60_Y 1.425 0.99
10_L 61_L 1.402 0.99
77_F 89_E 1.398 0.99
132_K 136_S 1.387 0.99
90_T 134_F 1.316 0.98
41_A 45_R 1.308 0.98
29_A 58_F 1.305 0.98
32_S 40_A 1.278 0.98
35_T 139_D 1.275 0.98
50_E 53_H 1.27 0.98
64_T 113_D 1.264 0.98
45_R 133_L 1.255 0.98
7_I 61_L 1.243 0.97
87_F 137_I 1.242 0.97
80_Y 89_E 1.239 0.97
8_E 12_E 1.239 0.97
145_G 148_G 1.231 0.97
31_C 83_L 1.22 0.97
27_M 80_Y 1.219 0.97
125_S 129_E 1.217 0.97
34_H 77_F 1.205 0.97
105_A 121_Q 1.199 0.97
17_E 53_H 1.181 0.96
127_Q 130_E 1.159 0.96
140_K 157_E 1.152 0.96
37_E 140_K 1.148 0.95
17_E 127_Q 1.135 0.95
77_F 122_W 1.13 0.95
60_Y 116_T 1.129 0.95
118_N 121_Q 1.127 0.95
121_Q 125_S 1.127 0.95
152_Y 156_K 1.124 0.95
46_H 133_L 1.119 0.95
96_L 99_Q 1.119 0.95
30_W 34_H 1.108 0.94
105_A 124_V 1.104 0.94
32_S 37_E 1.096 0.94
106_H 114_Y 1.09 0.93
49_E 53_H 1.086 0.93
102_N 114_Y 1.085 0.93
9_K 104_L 1.084 0.93
24_Y 94_E 1.074 0.93
65_G 135_K 1.073 0.93
109_M 112_Q 1.072 0.93
52_T 56_R 1.072 0.93
71_N 75_S 1.069 0.93
21_S 47_A 1.068 0.93
84_D 88_Q 1.067 0.93
77_F 85_E 1.064 0.92
94_E 127_Q 1.063 0.92
50_E 130_E 1.057 0.92
75_S 78_A 1.057 0.92
88_Q 92_K 1.048 0.92
25_Q 28_S 1.044 0.91
26_Q 80_Y 1.028 0.91
30_W 86_L 1.021 0.90
56_R 122_W 1.008 0.89
5_E 8_E 1.008 0.89
135_K 139_D 1.006 0.89
56_R 123_Y 1.006 0.89
19_Y 76_P 1.005 0.89
16_L 96_L 1 0.89
50_E 97_I 1 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1z6oA120.97581000.242Contact Map0.533
1vlgA80.98181000.27Contact Map0.854
1z6oM120.98791000.276Contact Map0.677
3a68A240.99391000.291Contact Map0.751
1eumA611000.297Contact Map0.805
3vnxA10.98181000.298Contact Map0.62
1s3qA1211000.31Contact Map0.884
3bvfA611000.322Contact Map0.795
3kxuA111000.323Contact Map0.587
1krqA111000.325Contact Map0.654

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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