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ARAC - Arabinose operon regulatory protein
UniProt: P0A9E0 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10054
Length: 292 (246)
Sequences: 11517
Seq/Len: 46.82

ARAC
Paralog alert: 0.76 [within 20: 0.19] - ratio of genomes with paralogs
Cluster includes: ADIY APPY ARAC CHBR ENVY EUTR FEAR GADW GADX MARA MELR RHAR RHAS SOXS YBCM YDEO YDIP YEAM YIDL YIJO YKGD YPDC YQHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
232_I 269_T 3.455 1.00
189_H 192_D 3.249 1.00
244_M 252_N 3.088 1.00
198_A 208_P 3.056 1.00
185_Y 189_H 3.054 1.00
221_I 229_D 3.003 1.00
234_Q 237_L 2.873 1.00
236_K 269_T 2.847 1.00
265_F 276_F 2.83 1.00
187_S 230_Q 2.724 1.00
235_A 261_F 2.407 1.00
238_L 252_N 2.357 1.00
229_D 268_C 2.349 1.00
186_I 227_R 2.318 1.00
196_D 199_S 2.18 1.00
215_F 226_W 2.152 1.00
56_V 63_E 2.068 1.00
238_L 244_M 2.049 1.00
244_M 248_T 2.017 1.00
239_L 246_I 2.006 1.00
45_Y 76_P 2.003 1.00
232_I 268_C 1.962 1.00
54_Q 65_V 1.891 1.00
245_P 248_T 1.878 1.00
56_V 65_V 1.874 1.00
182_A 211_L 1.869 1.00
234_Q 238_L 1.868 1.00
238_L 253_V 1.847 1.00
186_I 230_Q 1.842 1.00
190_L 230_Q 1.821 1.00
206_L 211_L 1.82 1.00
179_V 219_L 1.787 1.00
52_R 92_Y 1.783 1.00
184_Q 188_D 1.768 1.00
155_L 158_Q 1.767 1.00
185_Y 203_H 1.764 1.00
271_A 279_G 1.751 1.00
54_Q 67_R 1.75 1.00
67_R 70_D 1.749 1.00
224_L 228_E 1.707 1.00
58_K 63_E 1.706 1.00
185_Y 195_F 1.69 1.00
182_A 204_V 1.629 1.00
197_I 212_S 1.628 1.00
274_S 278_A 1.619 1.00
187_S 226_W 1.615 1.00
200_V 223_V 1.601 1.00
51_I 94_Q 1.593 1.00
248_T 252_N 1.584 1.00
236_K 276_F 1.575 1.00
210_R 214_L 1.567 1.00
247_A 258_Q 1.561 1.00
235_A 253_V 1.537 1.00
242_T 277_R 1.522 1.00
183_C 219_L 1.514 1.00
190_L 234_Q 1.485 1.00
46_I 80_H 1.466 1.00
262_S 272_S 1.462 1.00
198_A 202_Q 1.458 1.00
247_A 251_R 1.44 1.00
211_L 223_V 1.439 1.00
131_S 135_G 1.427 1.00
60_Q 78_E 1.423 1.00
248_T 251_R 1.418 1.00
222_S 225_S 1.411 1.00
192_D 199_S 1.404 0.99
249_V 253_V 1.402 0.99
206_L 210_R 1.4 0.99
58_K 81_H 1.399 0.99
210_R 213_H 1.397 0.99
208_P 212_S 1.393 0.99
237_L 241_T 1.387 0.99
271_A 275_E 1.378 0.99
56_V 83_G 1.369 0.99
154_N 158_Q 1.361 0.99
154_N 161_L 1.359 0.99
42_M 80_H 1.352 0.99
221_I 225_S 1.346 0.99
262_S 274_S 1.33 0.99
230_Q 234_Q 1.329 0.99
182_A 200_V 1.329 0.99
223_V 227_R 1.321 0.99
264_V 267_K 1.313 0.99
199_S 203_H 1.309 0.99
258_Q 262_S 1.304 0.99
260_Y 264_V 1.29 0.99
259_L 262_S 1.276 0.99
185_Y 200_V 1.269 0.99
40_L 80_H 1.268 0.99
52_R 68_P 1.262 0.99
272_S 275_E 1.254 0.99
244_M 249_V 1.254 0.99
151_L 158_Q 1.248 0.99
75_P 78_E 1.231 0.98
209_S 213_H 1.23 0.98
234_Q 253_V 1.222 0.98
178_R 204_V 1.202 0.98
200_V 203_H 1.193 0.98
140_A 165_E 1.189 0.98
242_T 249_V 1.188 0.98
257_D 263_R 1.188 0.98
178_R 206_L 1.181 0.98
144_E 148_S 1.156 0.97
246_I 249_V 1.154 0.97
255_F 264_V 1.142 0.97
50_T 53_G 1.134 0.97
197_I 223_V 1.131 0.97
158_Q 162_R 1.11 0.96
183_C 187_S 1.105 0.96
263_R 267_K 1.095 0.96
154_N 157_E 1.094 0.96
199_S 202_Q 1.093 0.96
212_S 223_V 1.047 0.94
39_P 79_I 1.047 0.94
204_V 211_L 1.045 0.94
229_D 233_S 1.04 0.94
201_A 208_P 1.037 0.94
55_G 66_C 1.033 0.94
207_S 210_R 1.027 0.94
42_M 46_I 1.018 0.93
269_T 276_F 1.017 0.93
176_D 218_Q 1.011 0.93
132_D 136_Q 1.003 0.93
231_R 253_V 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3gbgA10.90751000.313Contact Map0.648
3oouA10.36991000.53Contact Map0.782
3mn2A20.3631000.534Contact Map0.763
1bl0A10.42811000.536Contact Map0.734
3oioA10.3871000.536Contact Map0.799
2k9sA10.36641000.54Contact Map0.551
3mklA20.40411000.544Contact Map0.804
3lsgA50.352799.90.547Contact Map0.878
3w6vA10.482999.90.548Contact Map0.767
1d5yA40.400799.90.556Contact Map0.693

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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