GREMLIN.BAKERLAB.org
Powered by OPENSEQ.org
YEIL - Regulatory protein YeiL
UniProt: P0A9E9 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12031
Length: 219 (202)
Sequences: 6046
Seq/Len: 29.93

YEIL
Paralog alert: 0.78 [within 20: 0.09] - ratio of genomes with paralogs
Cluster includes: CRP FNR YEIL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
38_W 95_A 3.279 1.00
24_L 27_D 2.797 1.00
22_H 92_W 2.757 1.00
44_R 92_W 2.669 1.00
50_Y 86_Q 2.592 1.00
185_L 200_Q 2.55 1.00
143_A 180_F 2.433 1.00
103_P 107_N 2.377 1.00
43_T 94_L 2.368 1.00
187_I 194_L 2.277 1.00
138_L 168_V 2.249 1.00
187_I 196_K 2.224 1.00
139_V 179_Q 2.198 1.00
32_E 84_A 2.188 1.00
49_L 85_V 2.158 1.00
159_H 174_L 2.121 1.00
137_P 140_N 2.075 1.00
97_P 100_H 2.018 1.00
47_A 85_V 2.018 1.00
142_L 176_V 2.002 1.00
24_L 90_E 1.966 1.00
20_L 92_W 1.96 1.00
30_V 85_V 1.958 1.00
50_Y 84_A 1.952 1.00
197_N 200_Q 1.93 1.00
87_A 91_C 1.914 1.00
21_F 95_A 1.889 1.00
31_Q 34_Q 1.874 1.00
23_F 29_I 1.869 1.00
32_E 51_A 1.862 1.00
47_A 91_C 1.858 1.00
23_F 93_C 1.771 1.00
48_R 60_L 1.758 1.00
198_R 202_S 1.752 1.00
123_N 126_N 1.728 1.00
22_H 90_E 1.717 1.00
27_D 87_A 1.702 1.00
138_L 172_H 1.702 1.00
98_M 102_R 1.698 1.00
28_Y 86_Q 1.613 1.00
28_Y 31_Q 1.612 1.00
58_V 164_E 1.612 1.00
46_R 89_E 1.601 1.00
48_R 86_Q 1.554 1.00
178_A 182_H 1.542 1.00
126_N 130_L 1.516 1.00
25_A 90_E 1.508 1.00
48_R 58_V 1.507 1.00
179_Q 183_D 1.483 1.00
106_L 113_R 1.477 1.00
168_V 173_L 1.476 1.00
25_A 89_E 1.466 1.00
160_T 170_Y 1.445 1.00
100_H 103_P 1.442 1.00
139_V 183_D 1.442 1.00
145_F 166_L 1.431 1.00
64_F 68_C 1.397 0.99
132_Q 144_A 1.387 0.99
42_L 47_A 1.373 0.99
42_L 64_F 1.37 0.99
63_F 165_Y 1.37 0.99
160_T 164_E 1.362 0.99
180_F 185_L 1.352 0.99
181_I 188_K 1.337 0.99
159_H 170_Y 1.329 0.99
116_C 119_L 1.327 0.99
28_Y 84_A 1.32 0.99
136_F 144_A 1.308 0.99
72_E 122_K 1.302 0.99
112_L 116_C 1.292 0.99
181_I 187_I 1.287 0.99
77_D 124_Y 1.267 0.99
43_T 92_W 1.262 0.99
132_Q 136_F 1.26 0.99
40_F 95_A 1.253 0.99
199_K 202_S 1.252 0.99
36_P 81_E 1.25 0.99
53_L 57_R 1.241 0.98
29_I 47_A 1.23 0.98
17_D 100_H 1.228 0.98
42_L 91_C 1.225 0.98
20_L 43_T 1.203 0.98
200_Q 203_G 1.197 0.98
154_L 192_G 1.185 0.98
101_Y 105_L 1.153 0.97
48_R 161_Q 1.138 0.97
145_F 162_A 1.13 0.97
18_T 96_L 1.124 0.97
29_I 40_F 1.118 0.96
143_A 201_L 1.117 0.96
131_T 135_S 1.108 0.96
103_P 106_L 1.103 0.96
20_L 94_L 1.098 0.96
142_L 166_L 1.09 0.96
166_L 173_L 1.084 0.96
26_R 86_Q 1.082 0.96
169_S 172_H 1.07 0.95
46_R 65_A 1.059 0.95
102_R 106_L 1.051 0.94
49_L 64_F 1.044 0.94
13_D 107_N 1.037 0.94
19_R 95_A 1.035 0.94
18_T 94_L 1.033 0.94
170_Y 174_L 1.032 0.94
48_R 88_I 1.021 0.93
21_F 93_C 1.012 0.93
39_L 101_Y 1.011 0.93
13_D 108_D 1.004 0.93
143_A 147_L 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4ev0A20.95431000.255Contact Map0.819
3dv8A10.94521000.264Contact Map0.786
3dkwA100.93611000.266Contact Map0.857
3d0sA20.94061000.267Contact Map0.813
2gauA10.94981000.269Contact Map0.818
3e97A10.95891000.269Contact Map0.698
3e6cC10.98631000.274Contact Map0.751
2oz6A10.88581000.28Contact Map0.834
3fx3A20.97721000.281Contact Map0.781
3kccA20.90871000.281Contact Map0.88

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0242 seconds.