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CUER - HTH-type transcriptional regulator CueR
UniProt: P0A9G4 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13256
Length: 135 (127)
Sequences: 5133
Seq/Len: 40.42

CUER
Paralog alert: 0.73 [within 20: 0.09] - ratio of genomes with paralogs
Cluster includes: CUER SOXR ZNTR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
92_E 102_R 4.439 1.00
88_V 106_L 3.587 1.00
95_I 99_Q 3.384 1.00
40_T 43_H 3.156 1.00
19_F 23_K 2.958 1.00
85_L 109_A 2.77 1.00
15_K 22_E 2.497 1.00
87_K 90_E 2.424 1.00
14_S 18_R 2.132 1.00
95_I 98_L 2.123 1.00
88_V 102_R 2.084 1.00
3_I 18_R 2.025 1.00
54_R 60_L 1.874 1.00
91_I 98_L 1.869 1.00
99_Q 102_R 1.8 1.00
32_S 38_T 1.787 1.00
92_E 106_L 1.767 1.00
6_V 47_L 1.708 1.00
88_V 109_A 1.695 1.00
4_S 8_K 1.675 1.00
84_T 109_A 1.633 1.00
23_K 64_G 1.619 1.00
62_E 87_K 1.601 1.00
46_E 71_N 1.569 1.00
88_V 92_E 1.529 1.00
94_H 97_E 1.523 1.00
6_V 43_H 1.466 1.00
93_R 97_E 1.461 1.00
59_N 62_E 1.441 1.00
17_I 39_Y 1.363 0.99
1_M 38_T 1.341 0.99
102_R 106_L 1.325 0.99
84_T 105_L 1.323 0.99
4_S 14_S 1.321 0.99
46_E 67_V 1.317 0.99
51_R 54_R 1.317 0.99
25_L 50_L 1.311 0.99
95_I 102_R 1.3 0.99
6_V 44_L 1.262 0.99
30_M 40_T 1.245 0.98
16_A 19_F 1.244 0.98
96_E 99_Q 1.235 0.98
13_T 16_A 1.223 0.98
2_N 38_T 1.222 0.98
90_E 93_R 1.184 0.98
5_D 8_K 1.181 0.98
98_L 102_R 1.175 0.98
81_K 85_L 1.167 0.97
10_T 44_L 1.167 0.97
91_I 102_R 1.133 0.97
89_A 93_R 1.096 0.96
20_Y 47_L 1.08 0.95
62_E 65_E 1.073 0.95
64_G 68_N 1.062 0.95
57_G 94_H 1.056 0.95
90_E 94_H 1.053 0.95
92_E 96_E 1.042 0.94
17_I 47_L 1.041 0.94
94_H 98_L 1.033 0.94
61_E 64_G 1.02 0.93
58_F 87_K 1.017 0.93
79_D 82_R 1.007 0.93
5_D 9_I 1.004 0.93
93_R 96_E 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1q06A211000.186Contact Map0.798
2dg6A111000.253Contact Map0.425
3hh0A40.97781000.268Contact Map0.83
2zhgA10.98521000.269Contact Map0.511
3gpvA20.97781000.274Contact Map0.764
3gp4A2199.90.28Contact Map0.851
3qaoA10.955699.90.323Contact Map0.562
1r8dA20.792699.90.337Contact Map0.855
2vz4A10.792699.90.342Contact Map0.501
1r8eA10.955699.90.36Contact Map0.515

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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