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ACEA - Isocitrate lyase
UniProt: P0A9G6 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10022
Length: 434 (431)
Sequences: 487
Seq/Len: 1.13

ACEA
Paralog alert: 0.09 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
52_K 149_D 3.566 1.00
306_H 311_G 3.476 1.00
299_R 303_Q 3.375 1.00
329_D 332_T 3.295 1.00
276_G 305_I 3.279 1.00
373_E 380_E 3.048 1.00
55_R 59_G 2.611 1.00
26_P 214_V 2.596 1.00
63_K 86_E 2.596 1.00
81_A 152_L 2.497 0.99
11_L 33_V 2.455 0.99
360_F 389_A 2.434 0.99
335_S 339_Q 2.272 0.99
78_L 127_T 2.212 0.98
367_N 392_D 2.175 0.98
183_V 216_A 2.124 0.98
236_D 291_S 2.096 0.97
22_G 312_K 2.095 0.97
48_L 149_D 2.074 0.97
129_R 151_F 2.053 0.97
101_L 114_A 2.03 0.97
214_V 414_I 2.013 0.97
117_V 175_M 2.004 0.96
368_A 377_H 1.968 0.96
390_A 397_V 1.941 0.96
236_D 297_L 1.919 0.95
378_Y 394_Y 1.89 0.95
241_I 265_T 1.871 0.94
208_E 212_K 1.833 0.93
12_Q 30_E 1.813 0.93
56_L 152_L 1.789 0.92
165_V 192_V 1.784 0.92
332_T 335_S 1.777 0.92
270_E 304_A 1.765 0.92
169_F 411_V 1.745 0.91
325_Q 330_D 1.727 0.90
101_L 115_N 1.717 0.90
135_Q 148_V 1.697 0.89
420_S 423_T 1.687 0.89
277_L 309_Y 1.683 0.89
272_A 288_C 1.68 0.89
296_E 300_R 1.675 0.89
394_Y 397_V 1.663 0.88
325_Q 384_Q 1.655 0.88
23_I 312_K 1.653 0.88
117_V 120_V 1.644 0.87
42_E 47_Q 1.629 0.87
77_A 124_I 1.627 0.87
69_L 362_M 1.615 0.86
192_V 208_E 1.607 0.86
169_F 223_T 1.599 0.85
265_T 271_Q 1.595 0.85
367_N 371_Q 1.591 0.85
192_V 212_K 1.588 0.85
357_S 361_N 1.563 0.83
65_Y 374_G 1.557 0.83
270_E 300_R 1.549 0.83
18_P 21_E 1.541 0.82
9_E 12_Q 1.53 0.82
291_S 297_L 1.524 0.81
338_Q 342_D 1.518 0.81
58_H 313_L 1.467 0.78
292_T 327_N 1.464 0.78
277_L 304_A 1.456 0.77
339_Q 342_D 1.437 0.76
165_V 208_E 1.435 0.76
72_L 99_A 1.435 0.76
390_A 394_Y 1.421 0.75
209_A 212_K 1.396 0.73
206_T 265_T 1.387 0.72
133_Q 177_E 1.374 0.71
253_I 264_R 1.365 0.70
82_K 402_E 1.361 0.70
43_C 223_T 1.357 0.70
306_H 312_K 1.35 0.69
376_K 379_V 1.345 0.69
295_L 339_Q 1.34 0.68
251_E 274_S 1.336 0.68
52_K 150_Y 1.334 0.68
373_E 376_K 1.332 0.68
88_V 124_I 1.326 0.67
83_A 139_G 1.323 0.67
241_I 253_I 1.316 0.66
395_T 402_E 1.313 0.66
267_A 271_Q 1.311 0.66
308_K 311_G 1.304 0.65
208_E 211_Q 1.301 0.65
34_K 410_K 1.301 0.65
118_P 171_L 1.298 0.65
138_A 401_Q 1.296 0.64
425_L 431_E 1.289 0.64
378_Y 397_V 1.276 0.63
114_A 174_A 1.271 0.62
12_Q 29_A 1.264 0.62
7_Q 36_R 1.259 0.61
47_Q 51_A 1.255 0.61
12_Q 15_W 1.25 0.60
294_D 297_L 1.25 0.60
277_L 305_I 1.246 0.60
101_L 119_A 1.246 0.60
269_I 300_R 1.245 0.60
117_V 121_V 1.244 0.60
126_N 129_R 1.244 0.60
29_A 33_V 1.235 0.59
370_A 379_V 1.233 0.59
172_M 183_V 1.232 0.59
14_E 29_A 1.222 0.58
364_D 385_P 1.222 0.58
88_V 315_A 1.221 0.58
258_T 264_R 1.219 0.57
277_L 308_K 1.208 0.56
364_D 392_D 1.197 0.55
57_L 313_L 1.197 0.55
102_A 174_A 1.194 0.55
273_I 304_A 1.19 0.55
401_Q 406_G 1.188 0.55
380_E 385_P 1.185 0.54
76_Q 358_M 1.182 0.54
209_A 288_C 1.18 0.54
209_A 271_Q 1.176 0.53
8_I 12_Q 1.175 0.53
9_E 13_K 1.173 0.53
45_L 430_E 1.172 0.53
355_I 396_F 1.172 0.53
51_A 226_P 1.169 0.53
236_D 305_I 1.168 0.53
192_V 211_Q 1.164 0.52
192_V 260_E 1.16 0.52
117_V 171_L 1.16 0.52
14_E 20_W 1.152 0.51
116_S 119_A 1.149 0.51
168_A 204_V 1.146 0.50
204_V 212_K 1.131 0.49
143_G 241_I 1.13 0.49
427_G 430_E 1.125 0.48
256_E 264_R 1.123 0.48
303_Q 343_M 1.122 0.48
304_A 307_A 1.117 0.48
165_V 211_Q 1.117 0.48
13_K 16_T 1.115 0.48
345_Y 432_S 1.114 0.47
63_K 341_S 1.113 0.47
28_S 266_H 1.113 0.47
59_G 62_K 1.111 0.47
335_S 338_Q 1.104 0.46
305_I 309_Y 1.102 0.46
68_S 362_M 1.099 0.46
11_L 224_G 1.099 0.46
6_Q 10_E 1.098 0.46
368_A 373_E 1.094 0.46
376_K 380_E 1.088 0.45
13_K 24_T 1.088 0.45
140_I 144_D 1.082 0.44
10_E 13_K 1.079 0.44
52_K 148_V 1.074 0.44
86_E 372_G 1.073 0.44
426_T 431_E 1.071 0.43
11_L 14_E 1.062 0.42
247_P 250_S 1.06 0.42
36_R 224_G 1.051 0.41
371_Q 391_K 1.049 0.41
329_D 335_S 1.045 0.41
90_L 109_Q 1.045 0.41
83_A 256_E 1.044 0.41
47_Q 425_L 1.039 0.40
405_T 431_E 1.038 0.40
248_Y 272_A 1.036 0.40
99_A 120_V 1.033 0.40
251_E 299_R 1.031 0.40
28_S 57_L 1.031 0.40
18_P 51_A 1.031 0.40
150_Y 395_T 1.028 0.39
245_C 266_H 1.027 0.39
48_L 52_K 1.023 0.39
204_V 341_S 1.022 0.39
204_V 209_A 1.012 0.38
192_V 242_T 1.008 0.38
17_Q 20_W 1.008 0.38
308_K 312_K 1.007 0.37
292_T 297_L 1.004 0.37
241_I 326_K 1.004 0.37
331_K 342_D 1.003 0.37
237_A 271_Q 1.003 0.37
15_W 300_R 1.002 0.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1dquA10.98621000.219Contact Map0.524
3lg3A211000.306Contact Map0.503
3i4eA40.98621000.312Contact Map0.577
3eolA20.98161000.321Contact Map0.542
1f8mA40.9771000.338Contact Map0.605
3lyeA10.68891000.772Contact Map0.427
1xg4A40.67281000.781Contact Map0.469
3fa4A120.68431000.785Contact Map0.522
1zlpA20.71891000.786Contact Map0.395
3eooA160.67741000.787Contact Map0.461

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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