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BTUR - Cob(I)yrinic acid a,c-diamide adenosyltransferase
UniProt: P0A9H5 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10130
Length: 196 (194)
Sequences: 1108
Seq/Len: 5.71

BTUR
Paralog alert: 0.15 [within 20: 0.03] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
129_L 158_I 3.525 1.00
165_R 169_E 3.279 1.00
173_T 183_A 3.037 1.00
179_P 185_D 2.722 1.00
49_A 125_L 2.647 1.00
147_L 156_V 2.6 1.00
106_R 142_E 2.514 1.00
42_T 46_F 2.404 1.00
155_T 191_Q 2.293 1.00
148_N 170_L 2.268 1.00
60_G 115_M 2.248 1.00
45_A 125_L 2.206 1.00
50_T 76_L 2.066 1.00
111_H 114_R 1.979 1.00
113_K 142_E 1.941 1.00
145_Q 149_E 1.861 1.00
140_L 166_D 1.834 1.00
31_I 158_I 1.821 1.00
129_L 143_V 1.813 1.00
85_Q 111_H 1.787 1.00
133_V 164_H 1.763 1.00
140_L 164_H 1.763 1.00
14_K 18_D 1.732 1.00
30_I 183_A 1.698 1.00
48_T 157_I 1.694 1.00
134_A 162_G 1.685 1.00
32_I 155_T 1.682 1.00
106_R 139_P 1.659 1.00
33_V 167_I 1.639 1.00
35_T 163_C 1.635 0.99
99_E 103_A 1.634 0.99
144_V 170_L 1.595 0.99
140_L 144_V 1.589 0.99
146_A 156_V 1.568 0.99
31_I 150_R 1.567 0.99
52_A 57_K 1.564 0.99
53_V 82_V 1.542 0.99
45_A 159_T 1.511 0.99
48_T 123_M 1.506 0.99
112_A 126_L 1.503 0.99
32_I 173_T 1.447 0.98
50_T 77_L 1.443 0.98
49_A 59_V 1.438 0.98
70_P 75_N 1.424 0.98
61_V 125_L 1.372 0.98
168_L 174_V 1.354 0.97
117_A 149_E 1.352 0.97
141_E 145_Q 1.345 0.97
83_E 121_L 1.327 0.97
32_I 191_Q 1.317 0.97
110_Q 113_K 1.316 0.97
31_I 147_L 1.311 0.97
174_V 181_K 1.308 0.97
74_R 78_E 1.3 0.96
83_E 115_M 1.28 0.96
34_F 44_A 1.277 0.96
176_E 180_V 1.237 0.95
49_A 61_V 1.236 0.95
37_N 179_P 1.225 0.95
55_H 72_G 1.215 0.94
32_I 183_A 1.198 0.94
57_K 122_D 1.195 0.94
130_T 163_C 1.185 0.93
18_D 21_V 1.181 0.93
106_R 110_Q 1.178 0.93
121_L 124_V 1.177 0.93
116_L 146_A 1.174 0.93
116_L 124_V 1.173 0.93
61_V 82_V 1.157 0.92
77_L 82_V 1.143 0.92
163_C 167_I 1.135 0.91
141_E 166_D 1.134 0.91
122_D 153_Q 1.132 0.91
88_A 105_C 1.129 0.91
103_A 107_E 1.129 0.91
163_C 168_L 1.12 0.90
13_V 17_V 1.115 0.90
144_V 148_N 1.115 0.90
46_F 50_T 1.103 0.90
62_V 112_A 1.103 0.90
118_D 121_L 1.102 0.89
31_I 170_L 1.101 0.89
46_F 61_V 1.093 0.89
183_A 188_V 1.087 0.89
116_L 154_Q 1.083 0.88
62_V 111_H 1.073 0.88
133_V 138_L 1.06 0.87
7_Q 11_Q 1.059 0.87
133_V 143_V 1.051 0.86
113_K 146_A 1.047 0.86
116_L 150_R 1.044 0.86
4_E 8_Q 1.04 0.85
58_K 120_S 1.039 0.85
88_A 108_V 1.026 0.84
90_G 93_W 1.002 0.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1g5tA111000.421Contact Map0.744
2orvA20.790899.90.623Contact Map0.594
2j9rA10.857199.80.721Contact Map0.563
1w4rA80.806199.70.745Contact Map0.688
1xx6A20.765399.70.751Contact Map0.654
3e2iA10.862299.60.756Contact Map0.595
2b8tA40.80199.40.789Contact Map0.653
2orwA20.729698.80.839Contact Map0.624
4blqA60.831696.40.902Contact Map0.519
2zr9A10.9235960.905Contact Map0.496

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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