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CFA - Cyclopropane-fatty-acyl-phospholipid synthase
UniProt: P0A9H7 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11531
Length: 382 (346)
Sequences: 1447
Seq/Len: 4.18

CFA
Paralog alert: 0.20 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
329_L 348_T 3.905 1.00
169_M 231_R 3.798 1.00
109_K 224_D 3.759 1.00
43_N 66_W 3.678 1.00
182_A 193_V 3.347 1.00
170_R 192_S 3.277 1.00
331_A 334_E 3.276 1.00
157_K 184_Y 3.113 1.00
64_D 342_R 3.06 1.00
42_K 68_E 3.055 1.00
159_I 264_L 2.87 1.00
203_Q 217_I 2.834 1.00
187_S 211_E 2.756 1.00
157_K 161_E 2.753 1.00
253_V 263_F 2.738 1.00
133_P 149_E 2.693 1.00
181_L 235_V 2.681 1.00
203_Q 207_Q 2.649 1.00
252_V 255_R 2.487 1.00
147_N 150_S 2.48 1.00
142_W 323_A 2.414 1.00
159_I 235_V 2.374 1.00
332_W 344_K 2.339 1.00
63_M 346_M 2.309 1.00
194_V 218_L 2.287 1.00
196_V 225_L 2.276 1.00
194_V 229_F 2.25 1.00
146_D 154_A 2.24 1.00
157_K 189_Y 2.145 1.00
238_F 267_T 2.139 1.00
171_V 185_M 2.098 1.00
176_C 195_G 2.081 1.00
136_Q 156_L 2.047 1.00
59_G 280_W 2.035 1.00
160_C 185_M 1.984 1.00
171_V 181_L 1.939 1.00
200_A 204_K 1.929 1.00
129_R 334_E 1.9 1.00
262_I 371_S 1.888 1.00
336_A 341_E 1.884 1.00
162_K 311_H 1.845 1.00
254_D 372_R 1.835 1.00
205_M 209_R 1.814 1.00
323_A 326_E 1.801 1.00
40_R 70_D 1.792 1.00
336_A 344_K 1.789 1.00
126_L 339_Y 1.742 0.99
332_W 336_A 1.725 0.99
129_R 335_I 1.716 0.99
143_K 146_D 1.71 0.99
319_T 323_A 1.692 0.99
49_R 66_W 1.646 0.99
252_V 256_N 1.644 0.99
195_G 217_I 1.628 0.99
232_I 256_N 1.626 0.99
156_L 180_G 1.608 0.99
136_Q 180_G 1.574 0.99
206_A 217_I 1.549 0.98
236_G 266_H 1.549 0.98
176_C 206_A 1.541 0.98
210_C 217_I 1.537 0.98
192_S 216_T 1.514 0.98
174_I 253_V 1.511 0.98
325_Y 348_T 1.511 0.98
169_M 191_V 1.504 0.98
76_F 356_G 1.469 0.97
325_Y 355_A 1.465 0.97
257_L 263_F 1.46 0.97
228_Q 259_P 1.441 0.97
312_N 364_Q 1.441 0.97
194_V 216_T 1.438 0.97
186_A 215_V 1.432 0.97
301_S 370_F 1.431 0.97
232_I 257_L 1.428 0.97
160_C 189_Y 1.422 0.97
186_A 213_L 1.42 0.97
139_C 236_G 1.419 0.97
183_H 187_S 1.414 0.96
107_Q 112_A 1.392 0.96
160_C 184_Y 1.388 0.96
311_H 316_D 1.388 0.96
157_K 188_N 1.382 0.96
234_S 249_Y 1.38 0.96
172_L 232_I 1.373 0.96
281_I 354_C 1.343 0.95
232_I 253_V 1.341 0.95
149_E 327_R 1.33 0.95
285_I 346_M 1.33 0.95
325_Y 329_L 1.321 0.94
334_E 337_D 1.318 0.94
201_E 204_K 1.312 0.94
124_N 135_M 1.308 0.94
262_I 369_V 1.304 0.94
228_Q 258_K 1.303 0.94
153_Q 188_N 1.293 0.93
230_D 258_K 1.287 0.93
170_R 194_V 1.285 0.93
247_D 300_S 1.267 0.93
123_G 339_Y 1.263 0.92
60_E 63_M 1.262 0.92
335_I 344_K 1.261 0.92
313_F 365_L 1.255 0.92
322_M 359_R 1.254 0.92
143_K 154_A 1.248 0.92
46_F 61_S 1.247 0.92
184_Y 188_N 1.243 0.92
146_D 150_S 1.235 0.91
182_A 217_I 1.229 0.91
162_K 369_V 1.227 0.91
156_L 181_L 1.22 0.91
197_T 219_L 1.22 0.91
165_L 191_V 1.218 0.90
168_G 191_V 1.202 0.90
357_A 362_D 1.193 0.89
294_V 310_W 1.189 0.89
164_Q 262_I 1.187 0.89
225_L 229_F 1.182 0.89
139_C 316_D 1.181 0.89
150_S 154_A 1.181 0.89
166_K 169_M 1.17 0.88
291_L 363_I 1.169 0.88
197_T 203_Q 1.138 0.86
45_D 66_W 1.137 0.86
236_G 240_H 1.135 0.86
126_L 130_M 1.129 0.85
41_V 46_F 1.125 0.85
251_A 255_R 1.122 0.85
297_I 301_S 1.117 0.85
141_Y 158_M 1.116 0.84
38_D 70_D 1.109 0.84
231_R 262_I 1.1 0.83
42_K 65_G 1.094 0.83
122_L 127_F 1.091 0.83
71_R 74_M 1.09 0.83
183_H 215_V 1.086 0.82
259_P 372_R 1.085 0.82
307_M 310_W 1.073 0.81
284_Y 346_M 1.072 0.81
133_P 327_R 1.065 0.81
134_F 153_Q 1.062 0.80
307_M 368_V 1.062 0.80
139_C 266_H 1.061 0.80
124_N 201_E 1.061 0.80
61_S 66_W 1.059 0.80
322_M 355_A 1.057 0.80
181_L 185_M 1.042 0.78
264_L 369_V 1.041 0.78
319_T 322_M 1.041 0.78
355_A 359_R 1.038 0.78
158_M 311_H 1.038 0.78
163_L 191_V 1.032 0.78
134_F 156_L 1.031 0.77
126_L 335_I 1.029 0.77
128_S 135_M 1.025 0.77
327_R 330_A 1.025 0.77
167_P 190_D 1.014 0.76
56_L 59_G 1.009 0.75
149_E 153_Q 1.008 0.75
268_I 289_G 1.007 0.75
333_P 337_D 1.005 0.75
218_L 229_F 1.005 0.75
113_W 200_A 1.002 0.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2fk8A10.78271000.584Contact Map0.81
1kpgA40.70161000.586Contact Map0.805
3hemA10.72251000.605Contact Map0.775
3busA20.67541000.704Contact Map0.57
2o57A40.71471000.743Contact Map0.662
3ujcA10.65451000.751Contact Map0.558
4kriA30.95291000.764Contact Map0.549
3vc1A120.75921000.764Contact Map0.615
3kkzA20.63871000.77Contact Map0.543
3dliA30.57591000.789Contact Map0.543

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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