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CHEZ - Protein phosphatase CheZ
UniProt: P0A9H9 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10151
Length: 214 (213)
Sequences: 261
Seq/Len: 1.23

CHEZ
Paralog alert: 0.03 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
93_R 113_D 2.144 0.98
37_L 41_I 1.852 0.95
68_R 140_D 1.734 0.92
50_D 54_R 1.658 0.89
71_N 74_E 1.603 0.87
179_K 182_N 1.57 0.86
63_A 150_K 1.547 0.84
86_S 125_T 1.541 0.84
83_M 117_F 1.504 0.82
6_I 9_A 1.488 0.81
78_P 94_W 1.466 0.80
38_D 63_A 1.4 0.75
8_P 12_H 1.399 0.75
3_Q 6_I 1.396 0.75
97_W 107_A 1.388 0.74
96_D 106_D 1.385 0.74
159_I 186_L 1.375 0.73
4_P 11_E 1.374 0.73
7_K 10_D 1.368 0.73
169_E 204_Q 1.362 0.72
63_A 72_S 1.357 0.72
144_L 199_V 1.339 0.71
6_I 10_D 1.334 0.70
101_P 107_A 1.328 0.70
152_M 155_V 1.328 0.70
34_E 121_V 1.305 0.68
29_R 152_M 1.295 0.67
114_T 128_T 1.291 0.67
10_D 14_A 1.28 0.66
32_L 137_M 1.276 0.65
120_D 123_A 1.273 0.65
9_A 12_H 1.273 0.65
35_L 59_V 1.268 0.65
88_K 123_A 1.265 0.64
2_M 5_S 1.258 0.64
97_W 111_V 1.257 0.64
76_S 148_V 1.251 0.63
135_I 141_F 1.246 0.63
58_V 203_D 1.242 0.62
83_M 116_Q 1.23 0.61
2_M 7_K 1.227 0.61
19_A 74_E 1.225 0.61
5_S 8_P 1.224 0.61
7_K 11_E 1.217 0.60
80_Q 128_T 1.215 0.60
21_I 31_S 1.208 0.59
6_I 12_H 1.207 0.59
136_M 156_I 1.204 0.59
5_S 11_E 1.202 0.58
104_L 167_L 1.197 0.58
6_I 11_E 1.194 0.58
148_V 191_V 1.188 0.57
8_P 11_E 1.184 0.57
69_A 156_I 1.182 0.57
131_Q 211_S 1.181 0.56
94_W 110_L 1.177 0.56
66_A 207_D 1.176 0.56
103_D 111_V 1.158 0.54
29_R 153_M 1.157 0.54
53_D 93_R 1.155 0.54
79_H 124_H 1.151 0.53
97_W 108_R 1.15 0.53
16_D 201_S 1.14 0.52
104_L 108_R 1.137 0.52
5_S 13_S 1.137 0.52
18_I 153_M 1.132 0.52
24_L 156_I 1.131 0.52
90_L 122_P 1.129 0.51
4_P 7_K 1.122 0.51
51_A 151_R 1.118 0.50
120_D 125_T 1.118 0.50
25_T 211_S 1.112 0.50
61_M 64_Q 1.109 0.49
4_P 9_A 1.108 0.49
17_I 125_T 1.107 0.49
44_A 132_L 1.107 0.49
165_M 169_E 1.104 0.49
97_W 104_L 1.103 0.49
181_E 184_S 1.102 0.49
94_W 107_A 1.101 0.49
4_P 8_P 1.089 0.47
125_T 132_L 1.077 0.46
78_P 110_L 1.075 0.46
86_S 117_F 1.071 0.46
7_K 12_H 1.07 0.46
30_D 74_E 1.069 0.45
29_R 97_W 1.067 0.45
72_S 197_G 1.066 0.45
104_L 107_A 1.064 0.45
59_V 153_M 1.059 0.45
23_S 76_S 1.057 0.44
144_L 148_V 1.056 0.44
78_P 142_Q 1.056 0.44
34_E 149_I 1.053 0.44
167_L 172_P 1.053 0.44
29_R 107_A 1.049 0.44
156_I 171_I 1.047 0.43
63_A 142_Q 1.047 0.43
21_I 170_N 1.044 0.43
190_Q 200_A 1.044 0.43
38_D 142_Q 1.044 0.43
49_P 52_R 1.036 0.42
108_R 167_L 1.033 0.42
2_M 9_A 1.031 0.42
104_L 111_V 1.031 0.42
39_Q 74_E 1.027 0.41
2_M 6_I 1.024 0.41
117_F 182_N 1.023 0.41
3_Q 12_H 1.022 0.41
162_Q 186_L 1.019 0.41
20_R 169_E 1.017 0.40
177_R 183_Q 1.016 0.40
110_L 158_E 1.016 0.40
97_W 101_P 1.015 0.40
36_G 39_Q 1.012 0.40
39_Q 47_A 1.01 0.40
38_D 51_A 1.006 0.39
4_P 12_H 1.005 0.39
22_G 26_R 1.002 0.39
68_R 157_Q 1.001 0.39
131_Q 167_L 1.001 0.39
3_Q 13_S 1 0.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1kmiZ111000.18Contact Map0.225
3fx7A20.401927.90.96Contact Map0.444
3hoaA20.887914.30.965Contact Map0.197
1ka2A10.883213.50.965Contact Map0.206
2hc5A10.523411.50.966Contact Map0.062
2d3dA10.14029.90.967Contact Map0
1y9bA20.41599.50.967Contact Map0.333
1vf6C20.11217.20.969Contact Map
3ci9A20.20097.10.969Contact Map0.842
3zmdA40.68696.40.97Contact Map0.187

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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