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CITE - Citrate lyase subunit beta
UniProt: P0A9I1 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13542
Length: 302 (289)
Sequences: 1616
Seq/Len: 5.59

CITE
Paralog alert: 0.41 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
22_G 59_V 4.878 1.00
256_R 275_N 4.396 1.00
205_Y 213_G 3.815 1.00
215_L 242_N 3.803 1.00
231_L 240_L 3.557 1.00
253_H 257_V 3.235 1.00
74_I 99_V 3.073 1.00
151_A 160_I 2.833 1.00
141_P 170_N 2.707 1.00
214_F 240_L 2.41 1.00
215_L 219_A 2.387 1.00
136_A 157_L 2.303 1.00
102_L 114_I 2.302 1.00
162_L 167_Y 2.216 1.00
184_F 188_S 2.191 1.00
51_E 54_T 2.188 1.00
56_R 88_D 2.173 1.00
238_D 242_N 2.131 1.00
258_V 291_L 2.123 1.00
16_S 241_H 2.07 1.00
167_Y 171_L 2.044 1.00
217_E 229_K 1.974 1.00
256_R 274_L 1.959 1.00
14_R 72_E 1.949 1.00
118_I 134_L 1.893 1.00
202_D 229_K 1.866 1.00
41_F 59_V 1.859 1.00
147_A 192_A 1.837 1.00
109_Q 112_L 1.833 1.00
255_R 295_E 1.759 1.00
74_I 101_R 1.751 1.00
146_R 149_E 1.748 1.00
57_R 61_H 1.704 1.00
164_A 203_T 1.7 1.00
207_D 210_N 1.651 1.00
257_V 274_L 1.638 0.99
115_E 119_L 1.637 0.99
111_V 136_A 1.634 0.99
79_A 82_S 1.615 0.99
285_D 288_R 1.607 0.99
145_T 188_S 1.606 0.99
108_A 149_E 1.586 0.99
212_A 215_L 1.581 0.99
107_T 110_D 1.576 0.99
208_A 273_S 1.564 0.99
214_F 239_L 1.531 0.99
24_N 27_M 1.53 0.99
252_D 256_R 1.518 0.99
87_N 90_E 1.513 0.99
122_E 156_R 1.502 0.99
77_V 85_G 1.496 0.99
23_A 51_E 1.495 0.99
136_A 150_I 1.489 0.99
165_E 282_P 1.477 0.99
145_T 195_S 1.476 0.99
248_Q 252_D 1.476 0.99
253_H 290_V 1.464 0.99
209_N 235_R 1.462 0.99
106_D 142_L 1.431 0.98
19_F 230_S 1.43 0.98
218_A 243_L 1.418 0.98
165_E 206_S 1.402 0.98
169_R 285_D 1.363 0.97
45_D 104_K 1.357 0.97
148_V 195_S 1.345 0.97
247_T 250_E 1.341 0.97
281_G 285_D 1.327 0.97
255_R 259_E 1.314 0.97
44_E 104_K 1.306 0.96
38_A 74_I 1.305 0.96
186_R 202_D 1.285 0.96
144_I 185_A 1.267 0.96
274_L 279_V 1.25 0.95
289_L 293_R 1.242 0.95
105_T 150_I 1.24 0.95
215_L 239_L 1.228 0.95
15_R 241_H 1.214 0.94
102_L 111_V 1.211 0.94
251_V 294_A 1.211 0.94
170_N 194_R 1.207 0.94
262_E 288_R 1.205 0.94
263_A 267_E 1.202 0.94
239_L 243_L 1.202 0.94
145_T 148_V 1.201 0.94
25_A 58_M 1.201 0.94
138_I 144_I 1.191 0.93
251_V 291_L 1.178 0.93
251_V 290_V 1.174 0.93
23_A 48_A 1.171 0.92
115_E 156_R 1.17 0.92
17_M 38_A 1.168 0.92
262_E 266_R 1.164 0.92
143_G 147_A 1.151 0.92
61_H 65_H 1.148 0.91
148_V 188_S 1.146 0.91
49_L 84_W 1.145 0.91
84_W 87_N 1.121 0.90
140_S 170_N 1.112 0.90
114_I 134_L 1.102 0.89
271_V 280_D 1.097 0.89
75_V 92_V 1.086 0.88
77_V 114_I 1.081 0.88
63_L 73_T 1.081 0.88
258_V 261_A 1.078 0.88
142_L 146_R 1.076 0.88
246_P 251_V 1.074 0.87
92_V 100_V 1.069 0.87
17_M 40_M 1.067 0.87
263_A 266_R 1.058 0.86
24_N 28_V 1.053 0.86
107_T 146_R 1.049 0.86
165_E 280_D 1.046 0.85
21_P 233_N 1.044 0.85
194_R 227_D 1.038 0.85
54_T 58_M 1.038 0.85
176_S 181_E 1.037 0.85
30_N 233_N 1.036 0.85
138_I 147_A 1.035 0.85
215_L 243_L 1.02 0.83
165_E 283_V 1.02 0.83
183_L 224_L 1.016 0.83
19_F 40_M 1.014 0.83
163_G 166_D 1.012 0.83
284_I 288_R 1.011 0.83
35_P 71_I 1.011 0.83
29_S 32_F 1.009 0.83
22_G 28_V 1.007 0.82
206_S 278_M 1.006 0.82
184_F 187_C 1 0.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3oyzA10.98681000.277Contact Map0.55
1sgjA30.92721000.279Contact Map0.798
3qqwA60.9571000.28Contact Map0.63
1u5hA10.88741000.283Contact Map0.695
3r4iA60.9571000.297Contact Map0.614
3qllA30.93711000.308Contact Map0.779
3cuxA10.99011000.326Contact Map0.527
3cuzA10.99011000.344Contact Map0.504
1p7tA10.99671000.385Contact Map0.437
3s9zA10.99341000.386Contact Map0.447

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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