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ARCA - Aerobic respiration control protein ArcA
UniProt: P0A9Q1 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10061
Length: 238 (228)
Sequences: 26799
Seq/Len: 117.54

ARCA
Paralog alert: 0.94 [within 20: 0.54] - ratio of genomes with paralogs
Cluster includes: ARCA BAER BASR BGLJ CPXR CREB CSGD CUSR DCUR DPIA EVGA FIMZ KDPE NARL NARP OMPR PHOB PHOP QSEB RCSB RSTA TORR UHPA UVRY YEDW YGEK YHJB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
16_R 32_E 3.576 1.00
16_R 34_T 2.763 1.00
37_A 59_G 2.545 1.00
20_K 32_E 2.541 1.00
9_V 39_M 2.534 1.00
35_D 59_G 2.483 1.00
182_R 202_D 2.462 1.00
199_R 202_D 2.361 1.00
31_F 48_I 2.347 1.00
164_S 167_R 2.345 1.00
60_K 68_E 2.335 1.00
86_E 106_N 2.311 1.00
165_E 211_H 2.31 1.00
20_K 24_E 2.286 1.00
36_G 60_K 2.153 1.00
89_K 109_E 2.142 1.00
35_D 38_E 2.138 1.00
61_N 64_L 2.002 1.00
141_G 155_D 1.977 1.00
22_I 107_P 1.96 1.00
5_H 29_D 1.937 1.00
40_H 68_E 1.895 1.00
223_A 233_C 1.881 1.00
138_K 143_E 1.86 1.00
170_L 174_E 1.842 1.00
50_L 114_A 1.838 1.00
34_T 38_E 1.809 1.00
204_T 207_R 1.808 1.00
33_A 42_I 1.805 1.00
150_S 158_Q 1.8 1.00
223_A 231_R 1.782 1.00
55_I 79_F 1.768 1.00
5_H 31_F 1.755 1.00
144_L 173_C 1.754 1.00
79_F 92_G 1.741 1.00
66_A 77_L 1.73 1.00
78_M 117_L 1.726 1.00
94_E 115_R 1.708 1.00
171_H 185_L 1.706 1.00
53_M 66_A 1.689 1.00
98_D 120_R 1.665 1.00
53_M 65_L 1.664 1.00
23_F 114_A 1.664 1.00
175_N 178_K 1.657 1.00
56_N 83_R 1.641 1.00
9_V 57_L 1.586 1.00
143_E 153_G 1.556 1.00
171_H 188_K 1.535 1.00
66_A 79_F 1.535 1.00
68_E 71_E 1.516 1.00
83_R 88_D 1.504 1.00
7_L 33_A 1.496 1.00
51_V 75_V 1.486 1.00
181_S 184_E 1.453 1.00
79_F 97_A 1.449 1.00
40_H 65_L 1.431 1.00
10_E 16_R 1.428 1.00
36_G 65_L 1.404 0.99
26_E 111_T 1.39 0.99
60_K 64_L 1.38 0.99
31_F 42_I 1.377 0.99
99_D 113_R 1.376 0.99
63_L 95_I 1.375 0.99
150_S 153_G 1.357 0.99
70_R 98_D 1.317 0.99
176_P 180_Q 1.307 0.99
55_I 63_L 1.305 0.99
180_Q 188_K 1.303 0.99
64_L 67_R 1.301 0.99
205_I 209_R 1.289 0.99
41_Q 45_E 1.283 0.99
145_D 148_S 1.265 0.99
171_H 180_Q 1.242 0.98
42_I 46_Y 1.242 0.98
37_A 60_K 1.24 0.98
225_I 231_R 1.236 0.98
42_I 45_E 1.233 0.98
28_Y 115_R 1.208 0.98
149_R 167_R 1.193 0.98
50_L 118_L 1.189 0.98
149_R 228_E 1.187 0.98
43_L 69_L 1.183 0.98
40_H 60_K 1.173 0.98
117_L 120_R 1.167 0.97
200_T 204_T 1.166 0.97
85_N 88_D 1.158 0.97
67_R 91_L 1.143 0.97
146_I 170_L 1.141 0.97
27_G 115_R 1.14 0.97
33_A 39_M 1.139 0.97
37_A 41_Q 1.138 0.97
144_L 166_F 1.137 0.97
31_F 46_Y 1.136 0.97
136_S 143_E 1.134 0.97
178_K 184_E 1.12 0.96
162_P 211_H 1.116 0.96
203_V 206_R 1.11 0.96
13_L 34_T 1.108 0.96
56_N 82_G 1.1 0.96
38_E 41_Q 1.099 0.96
153_G 158_Q 1.097 0.96
19_L 80_L 1.096 0.96
9_V 51_V 1.088 0.96
6_I 28_Y 1.085 0.96
44_S 72_Q 1.083 0.96
8_I 30_V 1.078 0.95
183_A 198_D 1.076 0.95
57_L 65_L 1.062 0.95
39_M 43_L 1.056 0.95
171_H 175_N 1.054 0.95
11_D 54_D 1.053 0.95
7_L 39_M 1.048 0.94
87_V 91_L 1.04 0.94
90_I 108_R 1.039 0.94
7_L 48_I 1.036 0.94
86_E 90_I 1.035 0.94
139_F 232_F 1.024 0.93
147_N 178_K 1.023 0.93
10_E 57_L 1.022 0.93
38_E 42_I 1.019 0.93
183_A 187_K 1.013 0.93
78_M 99_D 1.012 0.93
63_L 91_L 1.007 0.93
199_R 203_V 1.003 0.93
175_N 179_I 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2gwrA10.96221000.101Contact Map0.674
3r0jA20.96221000.102Contact Map0.675
1ys7A20.9581000.106Contact Map0.78
2oqrA10.96221000.111Contact Map0.564
4b09A120.97061000.133Contact Map0.672
1kgsA10.94121000.14Contact Map0.715
2hqrA20.9161000.154Contact Map0.677
1p2fA10.92021000.16Contact Map0.74
3q9sA10.90341000.174Contact Map0.682
3c3wA20.89921000.269Contact Map0.649

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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