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ACCD - Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
UniProt: P0A9Q5 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10217
Length: 304 (282)
Sequences: 1165
Seq/Len: 4.13

ACCD
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
65_L 113_G 3.665 1.00
120_V 157_I 3.555 1.00
54_R 200_D 3.445 1.00
230_P 244_G 3.19 1.00
121_V 145_A 3.161 1.00
116_Y 271_A 3.001 1.00
234_E 240_K 2.993 1.00
107_A 138_V 2.936 1.00
150_L 187_M 2.743 1.00
148_Q 152_D 2.72 1.00
116_Y 268_L 2.679 1.00
50_D 262_R 2.588 1.00
160_S 196_S 2.527 1.00
112_K 152_D 2.358 1.00
114_T 119_P 2.327 1.00
46_C 49_C 2.307 1.00
218_I 259_M 2.289 1.00
69_S 114_T 2.247 1.00
157_I 197_V 2.21 1.00
127_F 131_G 2.209 1.00
145_A 156_L 2.12 1.00
30_C 49_C 2.116 1.00
134_M 138_V 2.029 1.00
55_M 63_S 2.007 1.00
159_F 197_V 1.981 1.00
146_V 184_L 1.976 1.00
81_D 92_K 1.976 1.00
123_A 158_C 1.948 1.00
153_N 190_R 1.943 1.00
110_V 123_A 1.904 1.00
64_L 270_L 1.845 1.00
30_C 46_C 1.843 1.00
64_L 159_F 1.823 1.00
70_L 111_M 1.793 1.00
73_L 148_Q 1.774 0.99
123_A 156_L 1.76 0.99
121_V 154_C 1.745 0.99
259_M 269_K 1.735 0.99
71_V 112_K 1.73 0.99
44_E 59_N 1.722 0.99
150_L 192_L 1.709 0.99
148_Q 151_E 1.701 0.99
72_E 141_R 1.689 0.99
65_L 122_A 1.651 0.99
187_M 192_L 1.625 0.99
150_L 190_R 1.62 0.99
154_C 192_L 1.614 0.99
74_G 110_V 1.601 0.99
142_F 158_C 1.591 0.99
27_C 49_C 1.574 0.98
197_V 270_L 1.533 0.98
74_G 141_R 1.515 0.98
90_K 93_D 1.508 0.98
181_S 213_L 1.5 0.98
218_I 270_L 1.481 0.97
195_I 270_L 1.48 0.97
269_K 272_S 1.476 0.97
185_A 189_E 1.473 0.97
224_L 230_P 1.458 0.97
217_N 257_I 1.453 0.97
224_L 247_R 1.432 0.97
256_A 260_I 1.43 0.97
72_E 75_S 1.429 0.97
74_G 144_R 1.416 0.96
86_R 90_K 1.401 0.96
262_R 265_E 1.4 0.96
252_I 257_I 1.393 0.96
27_C 30_C 1.392 0.96
244_G 247_R 1.365 0.95
77_L 137_V 1.362 0.95
95_L 129_F 1.359 0.95
78_E 105_K 1.349 0.95
146_V 150_L 1.345 0.95
25_T 36_R 1.338 0.95
107_A 134_M 1.334 0.95
149_A 192_L 1.33 0.94
115_L 120_V 1.321 0.94
203_M 224_L 1.301 0.94
118_M 275_A 1.289 0.93
61_L 122_A 1.272 0.93
140_A 144_R 1.266 0.92
230_P 247_R 1.265 0.92
27_C 46_C 1.264 0.92
112_K 148_Q 1.264 0.92
99_Q 105_K 1.262 0.92
116_Y 267_R 1.259 0.92
143_V 146_V 1.25 0.92
58_R 72_E 1.248 0.92
58_R 104_E 1.234 0.91
96_A 100_K 1.226 0.91
87_D 94_R 1.218 0.90
218_I 261_V 1.217 0.90
45_V 52_H 1.208 0.90
34_L 47_P 1.207 0.90
57_A 109_V 1.189 0.89
24_W 35_Y 1.188 0.89
110_V 145_A 1.178 0.88
108_L 142_F 1.178 0.88
185_A 188_Q 1.169 0.88
112_K 119_P 1.165 0.87
158_C 184_L 1.165 0.87
38_E 41_R 1.157 0.87
143_V 183_A 1.155 0.87
180_T 213_L 1.151 0.87
219_A 248_S 1.15 0.87
136_S 172_M 1.139 0.86
57_A 61_L 1.136 0.86
143_V 179_K 1.136 0.86
196_S 217_N 1.107 0.84
61_L 111_M 1.09 0.82
8_K 11_I 1.084 0.82
125_F 210_F 1.08 0.81
74_G 148_Q 1.077 0.81
123_A 145_A 1.077 0.81
207_S 212_M 1.07 0.81
98_A 130_M 1.069 0.81
241_L 245_F 1.069 0.81
81_D 127_F 1.066 0.80
62_H 70_L 1.063 0.80
184_L 196_S 1.058 0.80
198_L 217_N 1.044 0.78
92_K 100_K 1.042 0.78
216_L 273_I 1.039 0.78
193_P 277_L 1.036 0.78
5_E 8_K 1.03 0.77
81_D 84_K 1.029 0.77
74_G 77_L 1.028 0.77
58_R 109_V 1.027 0.77
187_M 193_P 1.024 0.76
73_L 112_K 1.02 0.76
175_M 178_A 1.009 0.75
59_N 62_H 1.006 0.75
64_L 115_L 1.002 0.74
79_P 137_V 1.001 0.74
272_S 275_A 1 0.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2f9yB111000.434Contact Map0.797
2f9iB20.91781000.455Contact Map0.783
1vrgA60.91781000.534Contact Map0.727
1pixA20.91451000.601Contact Map0.68
3gf3A10.91781000.609Contact Map0.694
3u9rB10.92111000.611Contact Map0.62
3n6rB60.93091000.613Contact Map0.741
1on3A60.90461000.621Contact Map0.711
2bzrA60.95071000.626Contact Map0.746
1x0uA60.88161000.628Contact Map0.732

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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