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LIVG - High-affinity branched-chain amino acid transport ATP-binding protein LivG
UniProt: P0A9S7 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10537
Length: 255 (246)
Sequences: 70911
Seq/Len: 288.26

LIVG
Paralog alert: 0.94 [within 20: 0.83] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
35_S 221_S 3.498 1.00
7_S 27_E 3.162 1.00
146_H 149_R 3.161 1.00
32_E 223_R 3.074 1.00
61_T 68_H 3.068 1.00
34_V 225_Y 3.037 1.00
9_N 61_T 2.935 1.00
10_G 23_N 2.932 1.00
19_L 22_N 2.84 1.00
7_S 63_L 2.757 1.00
139_E 144_L 2.656 1.00
22_N 231_T 2.598 1.00
29_Y 32_E 2.434 1.00
14_R 19_L 2.428 1.00
8_V 11_L 2.364 1.00
97_V 154_L 2.321 1.00
223_R 235_N 2.316 1.00
81_G 173_E 2.313 1.00
12_M 23_N 2.3 1.00
236_G 240_Q 2.293 1.00
12_M 19_L 2.281 1.00
133_R 171_Q 2.279 1.00
65_R 173_E 2.247 1.00
13_M 50_C 2.193 1.00
12_M 59_G 2.097 1.00
135_A 147_A 2.036 1.00
237_T 240_Q 2.013 1.00
98_I 148_N 2.005 1.00
9_N 63_L 1.957 1.00
138_L 147_A 1.915 1.00
98_I 147_A 1.888 1.00
225_Y 232_P 1.847 1.00
198_E 202_H 1.839 1.00
30_P 173_E 1.838 1.00
98_I 135_A 1.834 1.00
32_E 222_D 1.816 1.00
140_R 198_E 1.799 1.00
10_G 25_N 1.752 1.00
15_F 20_A 1.738 1.00
171_Q 205_T 1.71 1.00
13_M 58_T 1.705 1.00
149_R 153_N 1.696 1.00
133_R 136_T 1.689 1.00
225_Y 235_N 1.628 1.00
200_R 222_D 1.627 1.00
136_T 140_R 1.576 1.00
14_R 58_T 1.55 1.00
87_Q 156_Y 1.55 1.00
98_I 134_A 1.545 1.00
63_L 68_H 1.498 1.00
140_R 203_H 1.482 1.00
9_N 27_E 1.45 1.00
131_L 135_A 1.447 1.00
21_V 50_C 1.434 1.00
48_F 210_I 1.426 1.00
13_M 55_Y 1.418 1.00
50_C 57_P 1.413 1.00
26_L 225_Y 1.393 0.99
132_D 136_T 1.386 0.99
28_L 34_V 1.383 0.99
34_V 235_N 1.379 0.99
144_L 147_A 1.377 0.99
98_I 102_L 1.365 0.99
98_I 131_L 1.359 0.99
211_E 217_V 1.357 0.99
140_R 202_H 1.357 0.99
12_M 22_N 1.347 0.99
177_L 196_I 1.322 0.99
135_A 139_E 1.317 0.99
8_V 51_L 1.311 0.99
97_V 162_L 1.287 0.99
5_L 65_R 1.279 0.99
101_L 169_V 1.276 0.99
197_A 200_R 1.265 0.99
96_T 99_E 1.265 0.99
9_N 25_N 1.257 0.99
11_L 57_P 1.253 0.99
8_V 26_L 1.25 0.99
135_A 144_L 1.243 0.98
102_L 130_A 1.24 0.98
102_L 134_A 1.228 0.98
146_H 158_D 1.213 0.98
49_N 55_Y 1.21 0.98
48_F 176_M 1.21 0.98
133_R 137_W 1.209 0.98
33_I 200_R 1.208 0.98
29_Y 223_R 1.206 0.98
173_E 205_T 1.201 0.98
236_G 241_I 1.187 0.98
141_I 165_A 1.186 0.98
73_P 76_Q 1.168 0.97
126_A 129_E 1.165 0.97
8_V 47_V 1.162 0.97
100_N 166_R 1.155 0.97
195_L 198_E 1.155 0.97
30_P 65_R 1.147 0.97
189_T 216_L 1.13 0.97
193_D 216_L 1.104 0.96
150_Q 153_N 1.104 0.96
33_I 207_I 1.102 0.96
51_L 208_L 1.097 0.96
200_R 207_I 1.096 0.96
68_H 71_G 1.093 0.96
171_Q 203_H 1.092 0.96
199_L 205_T 1.088 0.96
102_L 131_L 1.086 0.96
13_M 46_T 1.085 0.96
129_E 133_R 1.078 0.95
137_W 169_V 1.077 0.95
129_E 132_D 1.066 0.95
197_A 219_G 1.064 0.95
47_V 227_V 1.057 0.95
191_E 194_E 1.055 0.95
65_R 81_G 1.052 0.95
137_W 165_A 1.041 0.94
36_L 208_L 1.039 0.94
142_G 191_E 1.036 0.94
34_V 223_R 1.033 0.94
24_V 47_V 1.033 0.94
36_L 47_V 1.028 0.94
15_F 46_T 1.023 0.93
11_L 50_C 1.019 0.93
52_T 176_M 1.014 0.93
136_T 139_E 1.014 0.93
14_R 20_A 1.011 0.93
15_F 55_Y 1.009 0.93
96_T 150_Q 1.008 0.93
99_E 102_L 1.005 0.93
154_L 162_L 1.005 0.93
189_T 213_D 1.004 0.93
50_C 62_I 1.003 0.93
197_A 201_N 1.002 0.92
10_G 59_G 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiC40.9412100-0.039Contact Map0.864
1v43A10.9294100-0.033Contact Map0.822
2yyzA10.9216100-0.032Contact Map0.802
2it1A20.9216100-0.032Contact Map0.858
1g29120.9333100-0.031Contact Map0.887
1oxxK10.9333100-0.025Contact Map0.788
3rlfA20.9216100-0.025Contact Map0.835
3fvqA20.9373100-0.019Contact Map0.772
1z47A20.9294100-0.018Contact Map0.823
3d31A20.898100-0.004Contact Map0.81

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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