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YBBA - Uncharacterized ABC transporter ATP-binding protein YbbA
UniProt: P0A9T8 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11657
Length: 228 (223)
Sequences: 70834
Seq/Len: 317.64

YBBA
Paralog alert: 0.94 [within 20: 0.87] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
40_A 213_C 3.25 1.00
8_E 32_V 3.019 1.00
37_E 215_R 3.01 1.00
139_R 142_H 3.009 1.00
89_H 166_D 2.861 1.00
66_E 73_P 2.842 1.00
10_H 66_E 2.83 1.00
11_H 28_G 2.805 1.00
39_I 217_L 2.7 1.00
24_S 27_T 2.669 1.00
8_E 68_S 2.575 1.00
132_E 137_G 2.467 1.00
27_T 223_Q 2.368 1.00
34_K 37_E 2.328 1.00
15_S 24_S 2.205 1.00
13_K 28_G 2.204 1.00
126_G 164_R 2.179 1.00
70_V 166_D 2.166 1.00
14_K 55_I 2.148 1.00
9_V 12_L 2.124 1.00
13_K 24_S 2.033 1.00
13_K 64_S 1.995 1.00
105_A 147_L 1.995 1.00
128_K 140_L 1.972 1.00
131_L 140_L 1.953 1.00
106_L 141_D 1.947 1.00
217_L 224_L 1.916 1.00
191_S 195_E 1.828 1.00
10_H 68_S 1.818 1.00
215_R 227_E 1.809 1.00
106_L 140_L 1.803 1.00
35_R 166_D 1.803 1.00
37_E 214_D 1.739 1.00
106_L 128_K 1.735 1.00
11_H 30_E 1.717 1.00
133_Q 191_S 1.668 1.00
16_V 25_I 1.659 1.00
164_R 198_T 1.645 1.00
133_Q 196_H 1.631 1.00
106_L 127_A 1.618 1.00
126_G 129_A 1.595 1.00
119_S 122_E 1.568 1.00
14_K 63_S 1.557 1.00
142_H 146_Q 1.526 1.00
129_A 133_Q 1.522 1.00
133_Q 195_E 1.51 1.00
124_R 128_K 1.508 1.00
70_V 89_H 1.463 1.00
95_Q 149_G 1.438 1.00
68_S 73_P 1.425 1.00
15_S 63_S 1.405 0.99
193_N 214_D 1.376 0.99
10_H 32_V 1.375 0.99
110_E 123_S 1.369 0.99
106_L 110_E 1.367 0.99
14_K 60_D 1.364 0.99
110_E 127_A 1.346 0.99
106_L 124_R 1.339 0.99
125_N 129_A 1.331 0.99
53_L 203_V 1.304 0.99
13_K 27_T 1.302 0.99
26_L 55_I 1.295 0.99
9_V 56_L 1.294 0.99
33_V 39_I 1.29 0.99
137_G 140_L 1.289 0.99
55_I 62_G 1.281 0.99
16_V 51_T 1.274 0.99
78_D 81_A 1.269 0.99
31_L 217_L 1.262 0.99
73_P 76_N 1.249 0.99
6_I 70_V 1.248 0.99
170_A 189_L 1.246 0.98
9_V 31_L 1.239 0.98
109_V 162_N 1.228 0.98
190_F 193_N 1.221 0.98
104_N 107_E 1.21 0.98
126_G 130_L 1.209 0.98
10_H 30_E 1.2 0.98
12_L 62_G 1.184 0.98
38_T 200_L 1.184 0.98
105_A 155_V 1.178 0.98
38_T 193_N 1.163 0.97
108_N 159_R 1.159 0.97
193_N 200_L 1.155 0.97
217_L 227_E 1.145 0.97
128_K 132_E 1.144 0.97
130_L 162_N 1.142 0.97
164_R 196_H 1.131 0.97
34_K 215_R 1.118 0.96
110_E 124_R 1.113 0.96
188_L 191_S 1.105 0.96
170_A 200_L 1.096 0.96
53_L 169_F 1.096 0.96
128_K 137_G 1.093 0.96
139_R 151_E 1.092 0.96
56_L 201_I 1.091 0.96
204_T 210_A 1.085 0.96
9_V 52_L 1.074 0.95
35_R 70_V 1.048 0.94
54_A 60_D 1.044 0.94
93_V 157_L 1.044 0.94
134_L 158_A 1.043 0.94
52_L 219_L 1.039 0.94
14_K 51_T 1.036 0.94
29_V 52_L 1.032 0.94
39_I 215_R 1.029 0.94
129_A 132_E 1.028 0.94
41_L 201_I 1.027 0.94
182_G 209_L 1.025 0.93
113_A 162_N 1.023 0.93
143_L 146_Q 1.022 0.93
166_D 198_T 1.015 0.93
17_G 22_E 1.014 0.93
122_E 125_N 1.014 0.93
104_N 141_D 1.01 0.93
186_A 209_L 1.008 0.93
55_I 67_V 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiC40.9956100-0.06Contact Map0.882
1g29120.9693100-0.043Contact Map0.901
2it1A20.943100-0.038Contact Map0.868
1v43A10.9561100-0.038Contact Map0.817
1oxxK10.9737100-0.037Contact Map0.819
2yyzA10.943100-0.037Contact Map0.809
3rlfA20.943100-0.032Contact Map0.838
1z47A20.9605100-0.03Contact Map0.832
3fvqA20.9649100-0.027Contact Map0.772
3d31A20.9167100-0.014Contact Map0.803

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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