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ZNUC - Zinc import ATP-binding protein ZnuC
UniProt: P0A9X1 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13132
Length: 251 (217)
Sequences: 69277
Seq/Len: 319.25

ZNUC
Paralog alert: 0.94 [within 20: 0.83] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
34_T 188_T 3.288 1.00
31_K 190_E 3.219 1.00
6_S 26_E 3.135 1.00
113_L 116_A 3.001 1.00
33_L 192_L 2.939 1.00
9_N 22_D 2.902 1.00
8_E 60_V 2.886 1.00
106_K 111_G 2.787 1.00
18_R 21_S 2.772 1.00
28_K 31_K 2.54 1.00
6_S 62_K 2.5 1.00
68_R 140_Q 2.465 1.00
190_E 201_S 2.451 1.00
21_S 197_H 2.449 1.00
13_S 18_R 2.368 1.00
11_S 22_D 2.314 1.00
7_L 10_V 2.274 1.00
11_S 18_R 2.254 1.00
202_G 206_V 2.183 1.00
11_S 58_E 2.16 1.00
100_D 138_R 2.156 1.00
12_V 49_V 2.149 1.00
203_T 206_V 2.048 1.00
105_L 114_I 1.962 1.00
102_L 114_I 1.938 1.00
8_E 62_K 1.88 1.00
107_R 165_Q 1.832 1.00
138_R 172_C 1.817 1.00
192_L 198_I 1.809 1.00
14_F 19_V 1.764 1.00
31_K 189_D 1.735 1.00
9_N 24_S 1.726 1.00
165_Q 169_E 1.719 1.00
103_P 107_R 1.697 1.00
29_P 140_Q 1.685 1.00
86_V 121_L 1.668 1.00
12_V 57_D 1.653 1.00
192_L 201_S 1.646 1.00
13_S 57_D 1.614 1.00
47_V 177_V 1.579 1.00
74_Q 123_G 1.579 1.00
116_A 120_K 1.563 1.00
25_L 192_L 1.496 1.00
100_D 103_P 1.495 1.00
98_K 102_L 1.494 1.00
47_V 143_V 1.438 1.00
87_N 114_I 1.43 1.00
167_R 189_D 1.424 1.00
111_G 114_I 1.419 1.00
20_L 49_V 1.418 1.00
27_L 33_L 1.417 1.00
8_E 26_E 1.384 0.99
12_V 54_V 1.381 0.99
49_V 56_P 1.369 0.99
107_R 169_E 1.366 0.99
7_L 50_V 1.36 0.99
102_L 106_K 1.354 0.99
7_L 25_L 1.337 0.99
11_S 21_S 1.315 0.99
144_L 163_I 1.3 0.99
102_L 111_G 1.298 0.99
10_V 56_P 1.292 0.99
99_E 103_P 1.288 0.99
87_N 115_N 1.274 0.99
85_T 88_R 1.272 0.99
87_N 102_L 1.27 0.99
107_R 170_L 1.269 0.99
178_S 184_V 1.254 0.99
33_L 201_S 1.228 0.98
100_D 104_A 1.215 0.98
8_E 24_S 1.213 0.98
113_L 125_E 1.212 0.98
93_R 96_T 1.205 0.98
202_G 207_V 1.202 0.98
28_K 190_E 1.193 0.98
87_N 101_I 1.175 0.98
32_I 167_R 1.17 0.97
12_V 45_T 1.167 0.97
164_D 167_R 1.163 0.97
156_Q 183_L 1.158 0.97
108_V 132_A 1.15 0.97
167_R 174_V 1.15 0.97
48_R 54_V 1.147 0.97
7_L 46_L 1.136 0.97
51_L 71_Y 1.118 0.96
85_T 89_F 1.106 0.96
14_F 45_T 1.097 0.96
162_L 165_Q 1.092 0.96
140_Q 172_C 1.087 0.96
160_Y 183_L 1.082 0.96
46_L 194_L 1.08 0.95
33_L 190_E 1.08 0.95
164_D 186_A 1.063 0.95
23_V 46_L 1.063 0.95
103_P 106_K 1.063 0.95
13_S 19_V 1.059 0.95
84_L 88_R 1.057 0.95
105_L 110_A 1.052 0.95
35_L 46_L 1.051 0.94
104_A 136_L 1.049 0.94
104_A 132_A 1.042 0.94
110_A 113_L 1.04 0.94
32_I 174_V 1.037 0.94
49_V 61_I 1.032 0.94
70_G 139_P 1.031 0.94
50_V 175_L 1.03 0.94
87_N 98_K 1.03 0.94
109_Q 158_A 1.03 0.94
117_P 120_K 1.015 0.93
32_I 176_M 1.014 0.93
166_L 172_C 1.014 0.93
7_L 61_I 1.01 0.93
9_N 58_E 1.01 0.93
158_A 161_D 1.003 0.93
103_P 138_R 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1v43A10.9921000.114Contact Map0.833
1g29120.9881000.12Contact Map0.899
2it1A20.9881000.121Contact Map0.876
2yyzA10.9881000.121Contact Map0.82
3rlfA20.9881000.122Contact Map0.851
3fvqA20.9921000.123Contact Map0.79
3tuiC40.9921000.124Contact Map0.857
1oxxK10.9881000.127Contact Map0.799
1z47A20.9921000.13Contact Map0.825
1g6hA10.86451000.133Contact Map0.818

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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