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CSPA - Cold shock protein CspA
UniProt: P0A9X9 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10166
Length: 70 (67)
Sequences: 2991
Seq/Len: 44.64

CSPA
Paralog alert: 0.78 [within 20: 0.16] - ratio of genomes with paralogs
Cluster includes: CSPA CSPB CSPC CSPD CSPE CSPF CSPG CSPH CSPI
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
56_E 65_G 3.928 1.00
32_V 67_V 3.863 1.00
54_T 66_N 2.947 1.00
49_Q 69_S 2.418 1.00
8_I 50_K 2.258 1.00
24_D 50_K 2.229 1.00
52_S 68_T 2.187 1.00
14_A 46_D 2.077 1.00
6_T 52_S 1.994 1.00
38_Q 66_N 1.875 1.00
36_A 65_G 1.81 1.00
5_M 23_P 1.725 1.00
6_T 50_K 1.708 1.00
52_S 70_L 1.697 1.00
23_P 53_F 1.635 1.00
57_S 62_P 1.613 1.00
23_P 26_G 1.602 1.00
23_P 27_S 1.595 1.00
64_A 67_V 1.57 1.00
58_G 63_A 1.562 1.00
32_V 45_L 1.503 1.00
14_A 44_S 1.419 1.00
38_Q 68_T 1.351 0.99
12_F 34_F 1.272 0.99
23_P 28_K 1.271 0.99
14_A 42_Y 1.244 0.98
6_T 24_D 1.225 0.98
34_F 37_I 1.194 0.98
39_N 69_S 1.186 0.98
46_D 49_Q 1.158 0.97
50_K 70_L 1.093 0.96
34_F 43_K 1.092 0.96
55_I 62_P 1.079 0.95
8_I 22_T 1.078 0.95
30_V 55_I 1.019 0.93
58_G 61_G 1.016 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2lssA1199.90.104Contact Map0.62
3camA20.957199.90.114Contact Map0.856
3i2zB2199.90.119Contact Map0.901
1h95A1199.80.131Contact Map0.581
1c9oA20.942999.80.135Contact Map0.865
2lxjA10.942999.80.136Contact Map0.565
1g6pA10.928699.80.148Contact Map0.49
3a0jA20.942999.80.15Contact Map0.841
2kcmA10.928699.80.156Contact Map0.517
3uljA20.971499.80.163Contact Map0.809

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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