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DSBE - Thiol:disulfide interchange protein DsbE
UniProt: P0AA86 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12053
Length: 185 (180)
Sequences: 918
Seq/Len: 5.10

DSBE
Paralog alert: 0.18 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: AHPC BCP DSBE TPX
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
45_V 138_L 2.827 1.00
150_D 156_R 2.718 1.00
73_L 149_I 2.711 1.00
78_T 112_A 2.381 1.00
104_N 112_A 2.368 1.00
109_R 128_F 2.066 1.00
74_N 86_E 1.964 1.00
47_K 63_D 1.942 1.00
70_P 151_G 1.904 1.00
172_I 176_W 1.768 1.00
150_D 154_I 1.753 1.00
165_P 169_E 1.738 1.00
173_K 177_E 1.726 1.00
90_L 100_V 1.715 1.00
92_Q 165_P 1.705 1.00
84_R 119_L 1.685 0.99
61_Q 64_V 1.682 0.99
134_L 138_L 1.655 0.99
76_W 104_N 1.625 0.99
32_D 35_N 1.622 0.99
175_L 178_K 1.618 0.99
169_E 173_K 1.577 0.99
75_V 103_M 1.573 0.99
76_W 112_A 1.521 0.99
82_T 88_Q 1.518 0.99
52_S 58_Q 1.503 0.99
82_T 143_A 1.501 0.99
13_F 17_A 1.483 0.98
74_N 146_T 1.477 0.98
75_V 138_L 1.467 0.98
101_V 125_L 1.461 0.98
62_A 67_Q 1.45 0.98
16_I 20_L 1.444 0.98
72_L 148_L 1.439 0.98
82_T 115_W 1.436 0.98
84_R 118_E 1.425 0.98
77_A 143_A 1.421 0.98
69_K 99_R 1.41 0.98
109_R 113_I 1.41 0.98
82_T 162_D 1.383 0.97
73_L 138_L 1.371 0.97
92_Q 95_A 1.369 0.97
177_E 180_S 1.363 0.97
21_L 25_A 1.297 0.96
9_P 13_F 1.286 0.95
70_P 148_L 1.271 0.95
85_A 162_D 1.255 0.94
168_W 172_I 1.235 0.94
91_N 122_P 1.21 0.93
108_D 111_K 1.21 0.93
142_G 145_E 1.197 0.92
86_E 146_T 1.196 0.92
47_K 62_A 1.189 0.92
163_L 168_W 1.187 0.92
106_K 132_G 1.186 0.92
48_F 134_L 1.184 0.92
73_L 103_M 1.176 0.91
71_V 149_I 1.151 0.90
115_W 119_L 1.131 0.89
87_H 115_W 1.129 0.89
47_K 61_Q 1.127 0.89
53_L 128_F 1.121 0.89
105_Y 143_A 1.118 0.88
175_L 179_Y 1.116 0.88
90_L 163_L 1.116 0.88
17_A 21_L 1.115 0.88
60_Y 65_L 1.11 0.88
102_G 146_T 1.098 0.87
62_A 71_V 1.096 0.87
115_W 123_Y 1.096 0.87
176_W 180_S 1.096 0.87
143_A 168_W 1.075 0.86
20_L 23_Q 1.073 0.86
1_M 5_V 1.073 0.86
19_A 23_Q 1.062 0.85
36_L 160_A 1.06 0.85
105_Y 135_G 1.058 0.84
70_P 176_W 1.058 0.84
45_V 73_L 1.055 0.84
139_G 145_E 1.046 0.84
11_I 15_A 1.045 0.83
20_L 24_L 1.039 0.83
49_R 59_F 1.036 0.83
114_S 118_E 1.03 0.82
146_T 163_L 1.027 0.82
131_D 134_L 1.025 0.82
100_V 124_A 1.024 0.82
78_T 81_P 1.015 0.81
59_F 110_Q 1 0.80
72_L 100_V 1 0.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2b1kA10.90811000.377Contact Map0.691
1kngA10.79461000.395Contact Map0.613
3eytA40.75681000.397Contact Map0.629
3lorA40.76761000.41Contact Map0.534
3kh7A10.94051000.414Contact Map0.667
2p5qA40.76761000.419Contact Map0.549
2hyxA40.91891000.42Contact Map0.611
2h30A10.83241000.43Contact Map0.531
2f9sA20.76761000.43Contact Map0.742
3eurA10.71891000.434Contact Map0.596

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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