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ISCA - Iron-binding protein IscA
UniProt: P0AAC8 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12132
Length: 107 (106)
Sequences: 2017
Seq/Len: 19.03

ISCA
Paralog alert: 0.68 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: ERPA ISCA SUFA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
76_Q 91_T 4.095 1.00
12_R 15_T 3.122 1.00
65_D 68_S 2.699 1.00
56_E 61_K 2.619 1.00
54_V 61_K 2.603 1.00
29_G 41_V 2.585 1.00
4_T 76_Q 2.494 1.00
95_V 98_E 2.453 1.00
7_D 58_K 2.408 1.00
10_A 58_K 2.293 1.00
25_G 63_V 2.205 1.00
56_E 59_G 2.105 1.00
7_D 57_D 1.903 1.00
6_S 78_D 1.866 1.00
27_R 52_D 1.822 1.00
48_P 63_V 1.812 1.00
75_T 90_F 1.728 1.00
25_G 61_K 1.699 1.00
81_K 86_E 1.65 1.00
14_N 18_A 1.533 1.00
22_K 46_D 1.515 1.00
31_R 41_V 1.514 1.00
3_I 77_L 1.478 1.00
87_G 90_F 1.45 1.00
97_D 106_H 1.331 0.99
69_L 73_D 1.264 0.99
13_V 26_L 1.231 0.98
11_A 14_N 1.224 0.98
14_N 59_G 1.193 0.98
48_P 54_V 1.171 0.98
8_S 78_D 1.166 0.97
82_E 89_K 1.16 0.97
15_T 18_A 1.136 0.97
75_T 103_E 1.125 0.97
36_S 106_H 1.118 0.96
70_Q 73_D 1.111 0.96
83_G 88_F 1.093 0.96
5_L 13_V 1.085 0.96
53_I 69_L 1.069 0.95
6_S 9_A 1.063 0.95
33_S 83_G 1.048 0.94
80_V 85_N 1.044 0.94
38_M 71_F 1.043 0.94
66_G 70_Q 1.032 0.94
12_R 16_F 1.032 0.94
55_F 69_L 1.031 0.94
67_K 70_Q 1.009 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2d2aA211000.028Contact Map0.781
1r94A211000.052Contact Map0.758
1nwbA111000.06Contact Map0.564
1x0gA40.99071000.069Contact Map0.839
2apnA111000.071Contact Map0.556
2k4zA10.962699.90.244Contact Map0.7
2p2eA10.962699.90.37Contact Map0.457
2qgoA10.953399.80.393Contact Map0.468
2nncA20.34589.10.927Contact Map0.213
3butA10.35516.10.932Contact Map0.026

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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