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TYRP - Tyrosine-specific transport protein
UniProt: P0AAD4 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11041
Length: 403 (403)
Sequences: 432
Seq/Len: 1.07

TYRP
Paralog alert: 0.82 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: MTR TNAB TYRP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
37_L 230_I 2.412 0.99
7_G 143_D 2.255 0.98
375_P 379_V 1.983 0.96
33_F 173_L 1.871 0.94
299_A 314_T 1.863 0.94
195_G 290_V 1.715 0.89
316_A 320_L 1.706 0.89
103_G 123_G 1.691 0.88
51_A 222_S 1.686 0.88
360_R 372_G 1.68 0.88
96_A 332_G 1.664 0.87
143_D 206_Y 1.656 0.87
15_T 23_A 1.656 0.87
7_G 206_Y 1.636 0.86
152_A 219_I 1.636 0.86
143_D 147_R 1.62 0.85
95_T 291_A 1.618 0.85
61_V 73_R 1.572 0.83
84_G 297_Y 1.567 0.82
198_G 293_G 1.536 0.81
94_L 195_G 1.499 0.78
119_S 122_A 1.478 0.77
90_L 225_P 1.464 0.76
71_A 79_G 1.463 0.76
23_A 189_V 1.441 0.74
227_V 385_I 1.429 0.74
89_F 330_P 1.421 0.73
199_S 348_A 1.406 0.72
101_G 283_L 1.406 0.72
16_T 153_K 1.403 0.72
56_E 360_R 1.403 0.72
52_L 215_R 1.403 0.72
13_A 224_I 1.399 0.71
198_G 348_A 1.394 0.71
370_V 373_G 1.394 0.71
30_G 293_G 1.367 0.69
373_G 377_L 1.361 0.68
358_Q 361_K 1.354 0.68
360_R 373_G 1.344 0.67
332_G 338_G 1.343 0.67
50_T 344_L 1.339 0.67
139_T 206_Y 1.338 0.66
259_L 283_L 1.335 0.66
110_I 119_S 1.331 0.66
341_G 392_F 1.331 0.66
86_S 327_L 1.329 0.66
227_V 374_R 1.329 0.66
155_I 208_D 1.328 0.66
100_S 124_V 1.317 0.65
195_G 340_A 1.316 0.65
96_A 338_G 1.304 0.63
38_I 41_I 1.304 0.63
51_A 201_P 1.303 0.63
290_V 319_F 1.302 0.63
94_L 196_F 1.301 0.63
15_T 64_D 1.297 0.63
202_S 296_D 1.297 0.63
350_I 381_F 1.271 0.61
317_I 320_L 1.264 0.60
14_G 44_W 1.256 0.59
299_A 310_G 1.254 0.59
41_I 361_K 1.251 0.59
48_C 218_F 1.25 0.59
110_I 114_T 1.247 0.58
358_Q 362_H 1.246 0.58
139_T 292_L 1.244 0.58
216_W 370_V 1.242 0.58
234_V 244_T 1.241 0.58
11_I 139_T 1.237 0.57
106_L 234_V 1.235 0.57
23_A 294_L 1.231 0.57
74_Y 355_L 1.224 0.56
55_L 69_T 1.222 0.56
290_V 348_A 1.221 0.56
344_L 348_A 1.218 0.56
312_L 375_P 1.214 0.55
13_A 19_A 1.214 0.55
94_L 293_G 1.209 0.55
6_L 125_L 1.207 0.55
119_S 316_A 1.204 0.54
164_L 349_L 1.2 0.54
210_N 346_V 1.2 0.54
23_A 102_A 1.191 0.53
70_L 279_A 1.19 0.53
171_V 240_I 1.189 0.53
89_F 293_G 1.188 0.53
7_G 139_T 1.188 0.53
47_M 89_F 1.183 0.52
286_S 333_F 1.181 0.52
225_P 337_L 1.178 0.52
212_R 216_W 1.176 0.52
153_K 225_P 1.166 0.51
296_D 299_A 1.162 0.50
146_N 347_L 1.159 0.50
361_K 374_R 1.155 0.50
38_I 126_L 1.155 0.50
69_T 300_D 1.151 0.49
54_L 137_V 1.149 0.49
115_G 262_L 1.148 0.49
23_A 44_W 1.145 0.49
116_I 385_I 1.138 0.48
97_A 322_P 1.138 0.48
14_G 18_G 1.137 0.48
199_S 293_G 1.137 0.48
393_L 398_L 1.137 0.48
360_R 370_V 1.136 0.48
11_I 199_S 1.136 0.48
126_L 316_A 1.135 0.48
89_F 343_A 1.128 0.47
101_G 149_L 1.126 0.47
100_S 336_A 1.126 0.47
7_G 11_I 1.124 0.47
230_I 261_A 1.122 0.47
324_A 393_L 1.121 0.47
17_I 183_A 1.121 0.47
38_I 82_L 1.114 0.46
131_A 236_T 1.114 0.46
227_V 382_L 1.113 0.46
322_P 360_R 1.113 0.46
8_S 26_L 1.113 0.46
68_G 146_N 1.111 0.46
115_G 129_F 1.111 0.46
152_A 224_I 1.11 0.46
68_G 218_F 1.11 0.46
41_I 106_L 1.109 0.45
32_G 96_A 1.105 0.45
28_A 102_A 1.104 0.45
102_A 143_D 1.101 0.45
131_A 235_A 1.1 0.45
375_P 378_V 1.098 0.44
38_I 227_V 1.098 0.44
258_L 261_A 1.093 0.44
51_A 157_L 1.093 0.44
227_V 389_G 1.091 0.44
67_L 138_G 1.088 0.43
298_L 349_L 1.085 0.43
106_L 167_H 1.085 0.43
87_M 255_L 1.082 0.43
154_I 354_L 1.081 0.43
343_A 348_A 1.079 0.43
42_G 187_I 1.079 0.43
14_G 20_G 1.077 0.42
58_Y 64_D 1.077 0.42
57_V 182_L 1.076 0.42
177_P 196_F 1.074 0.42
128_T 209_G 1.066 0.41
84_G 95_T 1.064 0.41
104_E 256_N 1.064 0.41
148_F 281_L 1.057 0.41
24_M 74_Y 1.056 0.41
160_M 281_L 1.055 0.40
107_A 151_S 1.053 0.40
19_A 85_F 1.047 0.40
323_L 327_L 1.047 0.40
156_F 236_T 1.047 0.40
53_L 370_V 1.042 0.39
58_Y 66_G 1.041 0.39
21_M 195_G 1.037 0.39
197_H 282_A 1.034 0.39
298_L 302_F 1.034 0.39
48_C 223_A 1.033 0.38
229_Y 290_V 1.032 0.38
92_Y 321_P 1.032 0.38
325_F 328_F 1.029 0.38
158_V 169_H 1.025 0.38
150_F 198_G 1.024 0.38
317_I 393_L 1.024 0.38
24_M 58_Y 1.022 0.37
8_S 93_A 1.021 0.37
374_R 392_F 1.021 0.37
392_F 396_A 1.02 0.37
7_G 147_R 1.02 0.37
188_P 282_A 1.019 0.37
50_T 337_L 1.019 0.37
356_T 360_R 1.017 0.37
111_S 114_T 1.017 0.37
135_V 303_Q 1.016 0.37
97_A 103_G 1.016 0.37
161_L 235_A 1.012 0.37
195_G 229_Y 1.011 0.36
15_T 18_G 1.011 0.36
207_M 285_T 1.01 0.36
132_G 291_A 1.009 0.36
9_V 131_A 1.008 0.36
337_L 340_A 1.007 0.36
135_V 223_A 1.007 0.36
183_A 274_A 1.007 0.36
310_G 313_Q 1.007 0.36
346_V 389_G 1.006 0.36
388_I 391_Q 1.006 0.36
246_M 385_I 1.005 0.36
152_A 218_F 1.005 0.36
44_W 88_M 1.005 0.36
355_L 390_V 1.003 0.36
132_G 315_G 1 0.36
9_V 12_V 1 0.36
19_A 373_G 1 0.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3l1lA10.972799.90.777Contact Map0.197
4djkA20.967799.90.804Contact Map0.16
3giaA10.952999.90.811Contact Map0.172
2jlnA10.923197.80.927Contact Map0.16
3dh4A40.9479970.937Contact Map0.166
2xq2A10.947996.60.94Contact Map0.189
2a65A10.965396.10.943Contact Map0.193
4m48A10.975290.30.955Contact Map0.139
3qrxB10.059618.40.975Contact Map0
3j45G10.1345.70.98Contact Map0

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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