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CYCA - D-serine/D-alanine/glycine transporter
UniProt: P0AAE0 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12504
Length: 470 (445)
Sequences: 10789
Seq/Len: 24.24

CYCA
Paralog alert: 0.82 [within 20: 0.39] - ratio of genomes with paralogs
Cluster includes: ADIC ANSP ARCD AROP CADB CYCA FRLA GABP GADC LYSP MMUP PHEP PLAP POTE PROY PUUP YBAT YCAM YGJI YIFK YJEH YJEM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
334_A 346_K 4.235 1.00
388_T 423_M 3.432 1.00
147_L 352_C 3.319 1.00
179_G 266_V 3.284 1.00
326_A 336_A 3.109 1.00
24_T 239_K 3.106 1.00
337_K 346_K 2.94 1.00
243_K 247_R 2.905 1.00
240_D 243_K 2.9 1.00
64_G 257_I 2.782 1.00
396_V 400_Q 2.777 1.00
140_L 359_V 2.699 1.00
294_A 298_V 2.427 1.00
420_W 424_A 2.423 1.00
329_G 333_K 2.386 1.00
391_L 422_C 2.364 1.00
334_A 337_K 2.296 1.00
323_F 327_Q 2.292 1.00
349_T 353_I 2.289 1.00
238_T 244_S 2.285 1.00
339_S 345_A 2.265 1.00
275_S 289_L 2.259 1.00
29_Q 251_S 2.226 1.00
104_G 325_L 2.205 1.00
25_N 251_S 2.197 1.00
65_F 421_V 2.164 1.00
73_A 391_L 2.13 1.00
25_N 244_S 2.117 1.00
88_S 328_E 2.115 1.00
177_V 181_V 2.051 1.00
92_S 100_G 2.047 1.00
92_S 97_P 2.042 1.00
55_S 214_F 2.036 1.00
24_T 27_H 2.001 1.00
335_F 350_F 2 1.00
272_P 275_S 1.995 1.00
236_A 327_Q 1.979 1.00
19_L 338_L 1.957 1.00
95_L 396_V 1.936 1.00
95_L 392_C 1.922 1.00
417_L 421_V 1.919 1.00
396_V 399_K 1.896 1.00
25_N 29_Q 1.891 1.00
28_I 238_T 1.84 1.00
151_L 345_A 1.834 1.00
76_E 398_R 1.833 1.00
247_R 251_S 1.825 1.00
237_E 320_R 1.813 1.00
65_F 69_F 1.81 1.00
166_M 170_V 1.81 1.00
147_L 348_L 1.806 1.00
108_W 351_S 1.772 1.00
151_L 349_T 1.738 1.00
48_T 56_I 1.729 1.00
59_V 217_G 1.726 1.00
148_T 152_A 1.709 1.00
447_P 451_I 1.708 1.00
169_I 173_V 1.685 1.00
155_K 159_E 1.657 1.00
444_L 448_L 1.644 1.00
414_L 418_M 1.641 1.00
27_H 162_F 1.637 1.00
240_D 244_S 1.636 1.00
98_W 457_W 1.619 1.00
91_A 103_T 1.611 1.00
103_T 389_I 1.606 1.00
73_A 419_C 1.594 1.00
392_C 423_M 1.589 1.00
240_D 247_R 1.586 1.00
61_M 261_V 1.579 1.00
23_L 27_H 1.576 1.00
241_P 246_P 1.555 1.00
29_Q 255_R 1.548 1.00
140_L 356_L 1.547 1.00
455_L 459_F 1.529 1.00
126_A 138_A 1.529 1.00
424_A 428_F 1.512 1.00
250_N 254_I 1.512 1.00
339_S 343_V 1.488 1.00
322_L 347_G 1.484 1.00
285_E 289_L 1.481 1.00
395_L 420_W 1.479 1.00
144_V 356_L 1.474 1.00
333_K 336_A 1.465 1.00
431_V 435_L 1.455 1.00
346_K 350_F 1.454 1.00
143_I 355_L 1.442 1.00
285_E 288_V 1.441 1.00
451_I 455_L 1.439 1.00
318_T 351_S 1.437 1.00
319_S 348_L 1.436 1.00
254_I 258_M 1.432 1.00
144_V 352_C 1.423 1.00
49_I 56_I 1.418 1.00
96_G 99_A 1.418 1.00
25_N 247_R 1.413 1.00
152_A 341_R 1.404 0.99
79_L 409_I 1.389 0.99
95_L 99_A 1.388 0.99
341_R 345_A 1.378 0.99
445_V 448_L 1.375 0.99
91_A 389_I 1.374 0.99
297_S 301_F 1.367 0.99
81_N 93_D 1.36 0.99
288_V 293_P 1.358 0.99
333_K 337_K 1.357 0.99
322_L 331_A 1.354 0.99
55_S 207_F 1.336 0.99
70_V 391_L 1.334 0.99
207_F 214_F 1.332 0.99
140_L 144_V 1.332 0.99
94_L 393_S 1.329 0.99
394_Y 419_C 1.321 0.99
234_T 316_F 1.321 0.99
353_I 357_G 1.316 0.99
36_A 256_I 1.314 0.99
23_L 158_G 1.312 0.99
193_V 198_A 1.309 0.99
150_N 312_N 1.305 0.99
32_A 252_I 1.291 0.99
279_E 285_E 1.291 0.99
392_C 396_V 1.285 0.99
84_Y 236_A 1.285 0.99
454_G 458_L 1.277 0.99
71_M 253_P 1.271 0.99
119_V 143_I 1.271 0.99
147_L 349_T 1.27 0.99
139_S 359_V 1.265 0.99
176_I 262_F 1.263 0.99
146_L 311_A 1.262 0.99
33_I 255_R 1.262 0.99
170_V 174_S 1.26 0.99
181_V 187_F 1.26 0.99
20_R 342_A 1.257 0.99
423_M 427_V 1.254 0.99
244_S 247_R 1.253 0.99
63_I 221_A 1.251 0.99
71_M 249_I 1.248 0.99
122_I 304_L 1.248 0.99
416_K 420_W 1.247 0.99
401_R 404_L 1.246 0.98
115_G 355_L 1.245 0.98
78_L 90_F 1.235 0.98
147_L 151_L 1.232 0.98
242_E 409_I 1.229 0.98
327_Q 336_A 1.223 0.98
19_L 323_F 1.218 0.98
448_L 451_I 1.217 0.98
57_I 265_I 1.215 0.98
143_I 352_C 1.214 0.98
101_Y 105_W 1.213 0.98
119_V 311_A 1.209 0.98
346_K 349_T 1.206 0.98
96_G 458_L 1.198 0.98
388_T 392_C 1.197 0.98
69_F 421_V 1.191 0.98
179_G 270_V 1.191 0.98
337_K 345_A 1.187 0.98
23_L 28_I 1.185 0.98
26_R 159_E 1.181 0.98
154_V 316_F 1.175 0.98
338_L 342_A 1.175 0.98
288_V 296_A 1.172 0.98
26_R 30_L 1.169 0.97
43_M 121_A 1.168 0.97
414_L 417_L 1.167 0.97
180_L 266_V 1.165 0.97
455_L 458_L 1.163 0.97
417_L 420_W 1.16 0.97
171_A 302_V 1.158 0.97
69_F 418_M 1.152 0.97
61_M 65_F 1.143 0.97
91_A 99_A 1.142 0.97
58_F 214_F 1.142 0.97
66_M 425_F 1.141 0.97
388_T 427_V 1.14 0.97
402_P 408_S 1.136 0.97
148_T 151_L 1.132 0.97
235_A 245_L 1.132 0.97
258_M 262_F 1.129 0.97
226_V 383_F 1.128 0.97
83_E 89_D 1.126 0.97
105_W 331_A 1.119 0.96
89_D 93_D 1.104 0.96
27_H 159_E 1.102 0.96
440_R 444_L 1.101 0.96
323_F 338_L 1.094 0.96
22_N 155_K 1.093 0.96
459_F 462_K 1.093 0.96
211_L 214_F 1.083 0.96
185_M 194_E 1.082 0.96
262_F 266_V 1.081 0.95
151_L 339_S 1.081 0.95
169_I 259_F 1.076 0.95
80_S 404_L 1.071 0.95
126_A 304_L 1.069 0.95
160_M 164_F 1.066 0.95
151_L 343_V 1.065 0.95
108_W 322_L 1.064 0.95
292_L 295_A 1.063 0.95
64_G 225_F 1.06 0.95
229_E 233_T 1.051 0.94
161_E 312_N 1.049 0.94
74_M 87_F 1.047 0.94
30_L 162_F 1.045 0.94
85_K 88_S 1.042 0.94
136_W 140_L 1.038 0.94
24_T 155_K 1.036 0.94
180_L 185_M 1.033 0.94
28_I 248_A 1.032 0.94
48_T 52_A 1.03 0.94
88_S 324_G 1.028 0.94
239_K 244_S 1.028 0.94
32_A 231_V 1.028 0.94
173_V 177_V 1.027 0.94
441_Q 445_V 1.026 0.94
448_L 452_A 1.025 0.93
428_F 432_L 1.024 0.93
457_W 461_G 1.018 0.93
105_W 453_L 1.017 0.93
399_K 402_P 1.015 0.93
27_H 158_G 1.006 0.93
452_A 456_G 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4djkA20.93621000.356Contact Map0.592
3l1lA10.9171000.372Contact Map0.686
3giaA10.89571000.386Contact Map0.604
2jlnA10.889498.50.883Contact Map0.422
3dh4A40.9298980.897Contact Map0.41
2xq2A10.927797.60.907Contact Map0.5
2a65A10.910694.90.93Contact Map0.37
4m48A10.921393.20.935Contact Map0.319
1wazA10.095713.50.968Contact Map0.72
1m56C20.14266.40.973Contact Map0.506

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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