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PROY - Proline-specific permease ProY
UniProt: P0AAE2 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13609
Length: 457 (445)
Sequences: 10764
Seq/Len: 24.19

PROY
Paralog alert: 0.82 [within 20: 0.39] - ratio of genomes with paralogs
Cluster includes: ADIC ANSP ARCD AROP CADB CYCA FRLA GABP GADC LYSP MMUP PHEP PLAP POTE PROY PUUP YBAT YCAM YGJI YIFK YJEH YJEM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
321_I 333_V 4.183 1.00
373_I 409_L 3.527 1.00
135_C 339_T 3.453 1.00
167_G 253_V 3.173 1.00
313_A 323_S 3.114 1.00
12_S 226_K 3.093 1.00
324_K 333_V 3 1.00
230_K 234_R 2.878 1.00
227_D 230_K 2.876 1.00
381_A 385_R 2.861 1.00
52_G 244_L 2.812 1.00
128_L 346_V 2.645 1.00
406_I 410_I 2.549 1.00
376_L 408_G 2.449 1.00
316_G 320_K 2.393 1.00
281_F 285_I 2.354 1.00
336_L 340_T 2.309 1.00
92_G 312_M 2.304 1.00
310_H 314_E 2.303 1.00
321_I 324_K 2.287 1.00
262_Q 276_H 2.263 1.00
225_A 231_S 2.259 1.00
326_S 332_W 2.238 1.00
259_P 262_Q 2.22 1.00
165_V 169_G 2.169 1.00
53_I 407_G 2.163 1.00
17_R 238_S 2.147 1.00
61_A 376_L 2.135 1.00
43_S 201_M 2.087 1.00
13_T 231_S 2.076 1.00
76_S 315_Q 2.06 1.00
7_L 325_T 2.017 1.00
322_F 337_V 2.016 1.00
80_Q 88_G 1.984 1.00
13_T 238_S 1.967 1.00
80_Q 85_P 1.966 1.00
223_G 314_E 1.952 1.00
83_L 377_L 1.943 1.00
83_L 381_A 1.925 1.00
430_Y 434_A 1.916 1.00
139_L 332_W 1.909 1.00
12_S 15_H 1.889 1.00
403_A 407_G 1.876 1.00
53_I 57_I 1.869 1.00
13_T 17_R 1.861 1.00
64_E 383_R 1.823 1.00
234_R 238_S 1.81 1.00
135_C 335_V 1.804 1.00
16_I 225_A 1.795 1.00
224_E 307_R 1.795 1.00
381_A 384_R 1.774 1.00
136_A 140_M 1.749 1.00
47_A 204_S 1.739 1.00
433_F 437_V 1.735 1.00
96_C 338_M 1.718 1.00
154_F 158_A 1.709 1.00
86_L 443_W 1.703 1.00
139_L 336_L 1.697 1.00
400_G 404_T 1.697 1.00
143_K 147_E 1.693 1.00
377_L 409_L 1.683 1.00
91_T 374_M 1.683 1.00
79_A 91_T 1.673 1.00
157_V 161_I 1.665 1.00
36_A 44_V 1.664 1.00
227_D 231_S 1.659 1.00
61_A 405_T 1.638 1.00
441_I 445_F 1.633 1.00
132_L 343_L 1.627 1.00
410_I 414_F 1.617 1.00
227_D 234_R 1.612 1.00
228_P 233_P 1.595 1.00
128_L 343_L 1.564 1.00
431_V 434_A 1.533 1.00
11_L 15_H 1.531 1.00
309_L 334_T 1.531 1.00
15_H 150_F 1.526 1.00
380_I 406_I 1.517 1.00
194_F 201_M 1.516 1.00
241_M 245_V 1.49 1.00
305_V 338_M 1.488 1.00
333_V 337_V 1.484 1.00
326_S 330_I 1.483 1.00
17_R 242_R 1.478 1.00
284_S 288_F 1.447 1.00
306_G 335_V 1.445 1.00
168_F 172_I 1.429 1.00
320_K 323_S 1.425 1.00
437_V 441_I 1.422 1.00
49_I 248_V 1.421 1.00
237_N 241_M 1.416 1.00
84_G 87_A 1.412 1.00
272_L 275_Q 1.408 1.00
272_L 276_H 1.402 0.99
82_N 378_S 1.399 0.99
37_I 44_V 1.396 0.99
379_Q 405_T 1.395 0.99
131_V 342_L 1.392 0.99
79_A 374_M 1.391 0.99
114_M 126_W 1.386 0.99
21_L 242_R 1.379 0.99
440_L 444_M 1.372 0.99
83_L 87_A 1.368 0.99
409_L 413_L 1.362 0.99
320_K 324_K 1.356 0.99
13_T 234_R 1.344 0.99
67_V 395_K 1.34 0.99
221_T 303_F 1.34 0.99
128_L 132_L 1.339 0.99
132_L 339_T 1.336 0.99
58_I 376_L 1.336 0.99
69_N 81_E 1.327 0.99
434_A 437_V 1.321 0.99
131_V 339_T 1.317 0.99
158_A 162_I 1.316 0.99
43_S 194_F 1.31 0.99
51_G 208_V 1.305 0.99
107_V 131_V 1.295 0.99
127_V 346_V 1.291 0.99
275_Q 280_T 1.29 0.99
110_F 291_L 1.288 0.99
138_N 299_N 1.285 0.99
89_Y 93_W 1.284 0.99
402_V 406_I 1.284 0.99
386_L 389_E 1.28 0.99
314_E 323_S 1.279 0.99
72_A 223_G 1.276 0.99
135_C 336_L 1.275 0.99
103_A 342_L 1.274 0.99
231_S 234_R 1.27 0.99
309_L 318_A 1.27 0.99
275_Q 283_A 1.268 0.99
107_V 298_I 1.267 0.99
57_I 407_G 1.267 0.99
377_L 381_A 1.257 0.99
11_L 146_G 1.256 0.99
59_M 240_P 1.252 0.99
387_P 391_V 1.246 0.98
66_S 78_Y 1.245 0.98
14_R 18_F 1.244 0.98
54_A 411_F 1.241 0.98
24_A 243_I 1.238 0.98
324_K 332_W 1.236 0.98
134_I 298_I 1.235 0.98
430_Y 433_F 1.232 0.98
168_F 253_V 1.23 0.98
229_E 395_K 1.228 0.98
31_Y 109_A 1.227 0.98
167_G 257_I 1.226 0.98
340_T 344_F 1.225 0.98
266_A 272_L 1.223 0.98
59_M 236_I 1.222 0.98
159_T 289_V 1.222 0.98
11_L 16_I 1.207 0.98
325_T 329_G 1.207 0.98
20_A 239_V 1.206 0.98
135_C 139_L 1.195 0.98
124_W 128_L 1.194 0.98
164_I 249_G 1.192 0.98
8_K 329_G 1.19 0.98
180_Q 185_H 1.181 0.98
77_R 81_E 1.179 0.98
7_L 310_H 1.175 0.98
71_A 77_R 1.165 0.97
142_V 303_F 1.164 0.97
333_V 336_L 1.162 0.97
93_W 439_L 1.159 0.97
36_A 40_A 1.157 0.97
84_G 444_M 1.154 0.97
46_L 201_M 1.149 0.97
45_L 252_F 1.149 0.97
373_I 413_L 1.148 0.97
222_A 232_I 1.139 0.97
213_G 368_T 1.137 0.97
417_G 421_Y 1.135 0.97
49_I 53_I 1.134 0.97
403_A 406_I 1.134 0.97
387_P 390_E 1.128 0.97
79_A 87_A 1.127 0.97
136_A 139_L 1.121 0.97
14_R 147_E 1.117 0.96
93_W 318_A 1.112 0.96
302_V 306_G 1.108 0.96
445_F 448_R 1.105 0.96
172_I 181_P 1.103 0.96
139_L 326_S 1.1 0.96
373_I 377_L 1.093 0.96
68_H 395_K 1.093 0.96
140_M 328_R 1.091 0.96
400_G 403_A 1.086 0.96
414_F 418_L 1.085 0.96
139_L 330_I 1.078 0.95
376_L 409_L 1.075 0.95
149_E 299_N 1.07 0.95
310_H 325_T 1.067 0.95
198_W 201_M 1.066 0.95
62_L 75_F 1.066 0.95
46_L 49_I 1.065 0.95
427_I 430_Y 1.064 0.95
226_K 231_S 1.063 0.95
216_E 220_I 1.062 0.95
249_G 253_V 1.059 0.95
20_A 218_I 1.058 0.95
148_L 152_F 1.056 0.95
10_G 143_K 1.053 0.95
57_I 404_T 1.052 0.95
52_G 212_Y 1.051 0.94
16_I 235_A 1.048 0.94
245_V 249_G 1.045 0.94
73_S 76_S 1.043 0.94
328_R 332_W 1.041 0.94
68_H 389_E 1.041 0.94
427_I 431_V 1.035 0.94
60_R 237_N 1.035 0.94
15_H 147_E 1.033 0.94
114_M 291_L 1.029 0.94
133_I 295_L 1.028 0.94
76_S 311_G 1.02 0.93
441_I 444_M 1.019 0.93
132_L 136_A 1.018 0.93
68_H 391_V 1.018 0.93
161_I 165_V 1.016 0.93
434_A 438_V 1.01 0.93
443_W 447_R 1.009 0.93
402_V 405_T 1.007 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4djkA20.96061000.323Contact Map0.597
3l1lA10.94531000.329Contact Map0.684
3giaA10.92341000.355Contact Map0.605
3dh4A40.934498.10.891Contact Map0.393
2xq2A10.934497.70.9Contact Map0.474
2jlnA10.890697.50.903Contact Map0.417
2a65A10.932294.20.929Contact Map0.434
4m48A10.95492.80.933Contact Map0.39
2wswA10.15756.40.971Contact Map0.376
3j1zP20.28236.10.971Contact Map0.301

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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