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ARCD - Putative arginine/ornithine antiporter
UniProt: P0AAE5 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13930
Length: 460 (424)
Sequences: 10305
Seq/Len: 24.30

ARCD
Paralog alert: 0.82 [within 20: 0.37] - ratio of genomes with paralogs
Cluster includes: ADIC ANSP ARCD AROP CADB CYCA FRLA GABP GADC LYSP MMUP PHEP PLAP POTE PROY PUUP YBAT YCAM YGJI YIFK YJEH YJEM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
320_I 332_A 4.324 1.00
142_H 338_N 3.662 1.00
174_A 251_L 3.503 1.00
312_A 322_A 3.314 1.00
323_R 332_A 3.237 1.00
47_G 242_L 3.121 1.00
379_K 383_R 3.079 1.00
228_R 232_K 2.879 1.00
135_S 346_V 2.643 1.00
335_W 339_I 2.588 1.00
315_K 319_R 2.498 1.00
325_N 331_S 2.494 1.00
225_R 228_R 2.483 1.00
11_T 236_L 2.482 1.00
309_F 313_T 2.402 1.00
7_L 236_L 2.369 1.00
260_E 275_E 2.363 1.00
320_I 323_R 2.356 1.00
172_V 176_M 2.352 1.00
88_A 311_A 2.294 1.00
224_A 229_D 2.286 1.00
280_W 284_I 2.26 1.00
56_A 374_G 2.255 1.00
222_A 313_T 2.223 1.00
59_I 381_A 2.213 1.00
7_L 229_D 2.201 1.00
72_F 314_H 2.195 1.00
321_F 336_L 2.151 1.00
79_F 379_K 2.124 1.00
6_G 9_A 2.107 1.00
79_F 375_A 2.079 1.00
76_R 81_E 2.052 1.00
7_L 11_T 2.024 1.00
223_R 306_E 2.022 1.00
379_K 382_T 2 1.00
142_H 334_L 1.993 1.00
232_K 236_L 1.988 1.00
76_R 84_G 1.977 1.00
257_A 260_E 1.957 1.00
146_L 331_S 1.926 1.00
92_W 337_T 1.899 1.00
48_A 52_L 1.896 1.00
150_Q 154_S 1.879 1.00
164_L 168_G 1.861 1.00
10_L 224_A 1.86 1.00
143_F 147_R 1.853 1.00
146_L 335_W 1.834 1.00
161_L 165_L 1.819 1.00
42_G 203_T 1.775 1.00
239_L 243_G 1.753 1.00
413_V 417_A 1.742 1.00
139_W 342_Q 1.734 1.00
38_A 200_V 1.678 1.00
87_S 372_L 1.656 1.00
44_G 246_L 1.637 1.00
138_L 341_V 1.626 1.00
89_W 419_G 1.623 1.00
9_A 157_L 1.615 1.00
11_T 240_S 1.611 1.00
135_S 342_Q 1.607 1.00
304_A 337_T 1.602 1.00
319_R 322_A 1.601 1.00
283_I 287_A 1.596 1.00
75_A 87_S 1.595 1.00
271_G 274_V 1.585 1.00
332_A 336_L 1.563 1.00
371_F 394_C 1.557 1.00
325_N 329_A 1.553 1.00
308_P 333_S 1.546 1.00
5_L 9_A 1.543 1.00
15_L 240_S 1.536 1.00
421_L 425_Y 1.532 1.00
225_R 232_K 1.531 1.00
30_M 39_L 1.53 1.00
54_A 238_V 1.523 1.00
235_L 239_L 1.523 1.00
305_A 334_L 1.516 1.00
271_G 275_E 1.513 1.00
7_L 232_K 1.502 1.00
165_L 169_L 1.497 1.00
220_V 302_I 1.476 1.00
80_G 83_I 1.472 1.00
327_Q 331_S 1.469 1.00
75_A 372_L 1.468 1.00
145_I 298_L 1.466 1.00
319_R 323_R 1.462 1.00
134_A 345_L 1.428 1.00
18_M 241_A 1.426 1.00
171_V 247_L 1.425 1.00
166_P 288_G 1.412 1.00
46_T 207_T 1.408 1.00
89_W 317_F 1.402 0.99
64_R 77_E 1.401 0.99
375_A 379_K 1.401 0.99
79_F 83_I 1.401 0.99
53_L 374_G 1.39 0.99
141_V 297_Y 1.389 0.99
147_R 327_Q 1.386 0.99
14_V 237_A 1.363 0.99
139_W 338_N 1.354 0.99
421_L 424_L 1.347 0.99
339_I 343_I 1.343 0.99
31_A 39_L 1.333 0.99
274_V 282_E 1.331 0.99
68_D 222_A 1.328 0.99
5_L 153_A 1.325 0.99
61_T 74_Y 1.313 0.99
264_I 271_G 1.308 0.99
142_H 335_W 1.304 0.99
225_R 229_D 1.302 0.99
78_G 376_F 1.299 0.99
103_L 107_F 1.298 0.99
212_I 366_I 1.297 0.99
138_L 338_N 1.297 0.99
395_I 399_W 1.294 0.99
226_N 231_G 1.29 0.99
410_L 414_V 1.289 0.99
8_S 154_S 1.285 0.99
174_A 255_V 1.284 0.99
308_P 317_F 1.278 0.99
149_V 302_I 1.272 0.99
229_D 232_K 1.269 0.99
5_L 10_L 1.265 0.99
146_L 329_A 1.255 0.99
417_A 421_L 1.255 0.99
135_S 139_W 1.253 0.99
164_L 244_V 1.252 0.99
2_E 328_A 1.24 0.98
8_S 12_A 1.239 0.98
313_T 322_A 1.239 0.98
44_G 48_A 1.228 0.98
66_E 73_T 1.227 0.98
142_H 146_L 1.222 0.98
324_Q 328_A 1.221 0.98
54_A 234_T 1.221 0.98
85_F 89_W 1.213 0.98
414_V 418_P 1.212 0.98
371_F 375_A 1.21 0.98
323_R 331_S 1.21 0.98
9_A 154_S 1.207 0.98
143_F 146_L 1.204 0.98
332_A 335_W 1.202 0.98
274_V 279_P 1.2 0.98
41_I 200_V 1.183 0.98
309_F 324_Q 1.182 0.98
126_N 129_Q 1.179 0.98
131_I 135_S 1.175 0.98
243_G 247_L 1.172 0.98
378_L 382_T 1.162 0.97
374_G 393_A 1.149 0.97
179_K 182_T 1.143 0.97
60_L 377_L 1.135 0.97
155_I 159_A 1.129 0.97
278_G 281_G 1.129 0.97
175_M 251_L 1.123 0.97
178_F 254_G 1.121 0.97
47_G 211_F 1.121 0.97
132_V 136_A 1.116 0.96
144_L 155_I 1.114 0.96
20_G 245_Y 1.111 0.96
75_A 376_F 1.111 0.96
77_E 384_P 1.107 0.96
40_L 250_L 1.107 0.96
397_G 400_L 1.106 0.96
41_I 44_G 1.098 0.96
4_K 150_Q 1.097 0.96
10_L 233_A 1.097 0.96
247_L 251_L 1.096 0.96
186_D 189_G 1.094 0.96
73_T 77_E 1.093 0.96
14_V 217_A 1.092 0.96
23_V 248_V 1.09 0.96
146_L 325_N 1.086 0.96
106_V 290_I 1.081 0.95
72_F 310_L 1.08 0.95
154_S 158_V 1.08 0.95
82_L 420_L 1.076 0.95
331_S 335_W 1.073 0.95
51_L 55_F 1.071 0.95
75_A 83_I 1.071 0.95
9_A 153_A 1.069 0.95
83_I 372_L 1.066 0.95
139_W 143_F 1.065 0.95
406_P 410_L 1.06 0.95
170_F 174_A 1.058 0.95
59_I 62_R 1.056 0.95
394_C 398_L 1.053 0.95
102_Y 105_I 1.052 0.95
414_V 417_A 1.048 0.94
301_T 305_A 1.047 0.94
103_L 297_Y 1.046 0.94
420_L 424_L 1.04 0.94
94_C 366_I 1.035 0.94
140_I 294_C 1.033 0.94
57_M 71_I 1.031 0.94
8_S 157_L 1.03 0.94
69_G 72_F 1.03 0.94
72_F 88_A 1.028 0.94
411_L 414_V 1.024 0.93
325_N 328_A 1.022 0.93
178_F 183_F 1.021 0.93
92_W 308_P 1.02 0.93
55_F 235_L 1.02 0.93
13_L 220_V 1.02 0.93
156_N 298_L 1.015 0.93
37_A 200_V 1.013 0.93
221_S 230_V 1.011 0.93
103_L 138_L 1.007 0.93
231_G 234_T 1.003 0.93
171_V 175_M 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3l1lA10.93481000.344Contact Map0.666
3giaA10.91091000.364Contact Map0.578
4djkA20.94781000.414Contact Map0.602
3dh4A40.947897.80.9Contact Map0.389
2xq2A10.947897.40.907Contact Map0.441
2jlnA10.8761960.922Contact Map0.43
2a65A10.895783.90.944Contact Map0.495
4m48A10.895783.70.944Contact Map0.449
2wswA10.771716.70.966Contact Map0.376
1wazA10.091350.973Contact Map0.71

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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