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CADB - Probable cadaverine/lysine antiporter
UniProt: P0AAE8 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10132
Length: 444 (418)
Sequences: 10755
Seq/Len: 25.73

CADB
Paralog alert: 0.82 [within 20: 0.38] - ratio of genomes with paralogs
Cluster includes: ADIC ANSP ARCD AROP CADB CYCA FRLA GABP GADC LYSP MMUP PHEP PLAP POTE PROY PUUP YBAT YCAM YGJI YIFK YJEH YJEM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
309_V 321_K 4.2 1.00
133_T 327_A 3.517 1.00
165_G 241_V 3.244 1.00
301_A 311_G 3.103 1.00
312_E 321_K 3.094 1.00
8_G 214_K 3.052 1.00
218_R 222_L 3.013 1.00
47_I 232_G 2.946 1.00
375_R 379_V 2.932 1.00
215_N 218_R 2.801 1.00
250_V 264_T 2.52 1.00
126_I 340_M 2.516 1.00
324_L 328_V 2.47 1.00
304_G 308_K 2.459 1.00
298_V 302_N 2.35 1.00
314_D 320_K 2.343 1.00
309_V 312_E 2.34 1.00
13_T 226_L 2.324 1.00
9_L 226_L 2.316 1.00
213_V 219_T 2.289 1.00
86_G 300_A 2.279 1.00
163_I 167_H 2.249 1.00
269_W 273_L 2.181 1.00
56_V 370_C 2.147 1.00
71_I 303_D 2.136 1.00
211_G 302_N 2.076 1.00
212_M 295_Q 2.012 1.00
77_I 371_V 2.01 1.00
75_G 79_P 2.008 1.00
9_L 219_T 2.001 1.00
310_Y 325_L 1.99 1.00
8_G 11_A 1.979 1.00
59_R 377_E 1.955 1.00
133_T 323_L 1.949 1.00
75_G 82_G 1.938 1.00
77_I 375_R 1.934 1.00
375_R 378_G 1.892 1.00
9_L 13_T 1.888 1.00
391_V 395_V 1.878 1.00
48_I 52_S 1.871 1.00
12_C 213_V 1.869 1.00
247_P 250_V 1.846 1.00
222_L 226_L 1.831 1.00
126_I 331_T 1.82 1.00
137_M 320_K 1.816 1.00
141_T 145_R 1.808 1.00
370_C 393_G 1.798 1.00
137_M 324_L 1.783 1.00
134_F 138_L 1.773 1.00
152_V 156_I 1.752 1.00
90_Y 326_A 1.749 1.00
386_S 390_S 1.731 1.00
155_L 159_V 1.725 1.00
42_G 192_S 1.722 1.00
85_T 368_Y 1.698 1.00
215_N 222_L 1.696 1.00
125_C 334_M 1.663 1.00
367_F 394_C 1.656 1.00
74_A 85_T 1.65 1.00
229_G 233_I 1.645 1.00
130_W 331_T 1.632 1.00
215_N 219_T 1.621 1.00
44_I 236_I 1.62 1.00
388_I 392_L 1.62 1.00
11_A 148_T 1.612 1.00
421_M 425_R 1.61 1.00
7_I 11_A 1.591 1.00
413_F 417_L 1.571 1.00
225_M 229_G 1.559 1.00
129_V 330_M 1.558 1.00
87_V 419_I 1.549 1.00
260_I 264_T 1.543 1.00
13_T 230_L 1.537 1.00
216_P 221_P 1.53 1.00
328_V 332_A 1.516 1.00
260_I 263_S 1.512 1.00
314_D 318_I 1.51 1.00
308_K 311_G 1.509 1.00
293_V 326_A 1.491 1.00
272_P 276_A 1.486 1.00
321_K 325_L 1.471 1.00
297_G 322_G 1.464 1.00
78_S 81_F 1.456 1.00
136_N 287_G 1.435 1.00
74_A 368_Y 1.431 1.00
20_M 231_A 1.426 1.00
156_I 160_M 1.422 1.00
9_L 222_L 1.417 1.00
162_A 237_A 1.414 1.00
97_N 330_M 1.412 1.00
101_G 129_V 1.412 1.00
308_K 312_E 1.402 0.99
77_I 81_F 1.402 0.99
54_A 228_T 1.4 0.99
209_S 291_M 1.397 0.99
410_A 414_I 1.39 0.99
133_T 324_L 1.387 0.99
38_I 189_I 1.385 0.99
53_L 370_C 1.382 0.99
101_G 286_L 1.377 0.99
294_G 323_L 1.376 0.99
371_V 375_R 1.368 0.99
7_I 144_S 1.365 0.99
219_T 222_L 1.362 0.99
17_A 230_L 1.348 0.99
108_L 124_A 1.342 0.99
297_G 306_F 1.34 0.99
46_S 196_C 1.338 0.99
263_S 271_A 1.336 0.99
130_W 327_A 1.333 0.99
132_F 286_L 1.332 0.99
61_A 73_Y 1.328 0.99
316_N 320_K 1.325 0.99
157_P 277_F 1.319 0.99
40_I 240_Q 1.304 0.99
395_V 399_I 1.299 0.99
174_Y 177_N 1.299 0.99
64_N 76_E 1.297 0.99
67_Q 211_G 1.295 0.99
54_A 224_T 1.289 0.99
122_G 126_I 1.288 0.99
138_L 316_N 1.285 0.99
367_F 371_V 1.285 0.99
263_S 268_N 1.282 0.99
254_S 260_I 1.282 0.99
27_L 103_T 1.282 0.99
16_V 227_G 1.276 0.99
417_L 421_M 1.271 0.99
387_L 391_V 1.268 0.99
126_I 130_W 1.261 0.99
7_I 12_C 1.252 0.99
133_T 137_M 1.251 0.99
129_V 327_A 1.247 0.99
313_V 317_G 1.242 0.98
267_G 270_A 1.24 0.98
104_A 279_A 1.233 0.98
421_M 424_A 1.232 0.98
201_V 362_T 1.232 0.98
52_S 392_L 1.229 0.98
175_A 178_W 1.225 0.98
123_I 127_A 1.216 0.98
298_V 313_V 1.214 0.98
165_G 245_M 1.213 0.98
176_A 179_N 1.208 0.98
66_Q 72_A 1.204 0.98
169_F 244_G 1.201 0.98
302_N 311_G 1.196 0.98
233_I 237_A 1.191 0.98
140_G 291_M 1.178 0.98
83_F 87_V 1.177 0.98
87_V 306_F 1.174 0.98
321_K 324_L 1.172 0.98
72_A 76_E 1.16 0.97
47_I 200_F 1.158 0.97
166_W 241_V 1.157 0.97
10_F 145_R 1.15 0.97
137_M 318_I 1.149 0.97
390_S 397_C 1.14 0.97
80_A 420_L 1.136 0.97
44_I 48_I 1.133 0.97
312_E 320_K 1.122 0.97
146_L 150_G 1.119 0.96
137_M 314_D 1.116 0.96
38_I 179_N 1.116 0.96
411_G 414_I 1.116 0.96
390_S 394_C 1.11 0.96
11_A 145_R 1.11 0.96
74_A 372_D 1.107 0.96
59_R 62_T 1.106 0.96
385_V 388_I 1.102 0.96
115_L 123_I 1.098 0.96
68_G 71_I 1.097 0.96
420_L 424_A 1.095 0.96
237_A 241_V 1.094 0.96
374_I 378_G 1.092 0.96
406_S 410_A 1.083 0.96
244_G 247_P 1.083 0.96
414_I 418_I 1.082 0.96
360_L 412_T 1.082 0.96
179_N 189_I 1.08 0.95
390_S 393_G 1.078 0.95
41_W 189_I 1.076 0.95
6_K 141_T 1.075 0.95
71_I 299_R 1.074 0.95
12_C 223_A 1.073 0.95
266_L 270_A 1.072 0.95
385_V 389_C 1.07 0.95
346_K 349_D 1.068 0.95
10_F 14_G 1.067 0.95
16_V 206_A 1.067 0.95
92_A 362_T 1.058 0.95
57_Y 70_P 1.057 0.95
314_D 317_G 1.054 0.95
135_V 146_L 1.049 0.94
186_G 189_I 1.048 0.94
74_A 81_F 1.047 0.94
134_F 137_M 1.045 0.94
394_C 398_F 1.043 0.94
58_A 62_T 1.043 0.94
290_M 294_G 1.042 0.94
60_L 373_L 1.04 0.94
11_A 144_S 1.04 0.94
393_G 397_C 1.038 0.94
397_C 400_A 1.036 0.94
174_Y 244_G 1.036 0.94
55_Y 225_M 1.032 0.94
6_K 214_K 1.03 0.94
177_N 180_T 1.02 0.93
374_I 387_L 1.017 0.93
24_G 235_Y 1.016 0.93
210_T 220_V 1.016 0.93
51_M 55_Y 1.014 0.93
214_K 219_T 1.013 0.93
32_L 39_A 1.012 0.93
4_A 317_G 1.009 0.93
155_L 234_V 1.008 0.93
8_G 141_T 1.008 0.93
49_G 396_F 1.006 0.93
147_T 287_G 1.003 0.93
41_W 44_I 1.003 0.93
204_E 208_V 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3l1lA10.98651000.27Contact Map0.672
3giaA10.96171000.312Contact Map0.585
4djkA20.97071000.357Contact Map0.588
3dh4A40.950598.20.885Contact Map0.428
2jlnA10.889698.10.889Contact Map0.407
2xq2A10.950597.90.894Contact Map0.496
2a65A10.925791.60.934Contact Map0.448
4m48A10.9482780.946Contact Map0.397
2wswA10.792855.10.954Contact Map0.284
4c7rA30.898624.70.962Contact Map0.386

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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