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ARAG - Arabinose import ATP-binding protein AraG
UniProt: P0AAF3 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10058
Length: 504 (492)
Sequences: 13966
Seq/Len: 28.39

ARAG
Paralog alert: 0.93 [within 20: 0.27] - ratio of genomes with paralogs
Cluster includes: ALSA ARAG GSIA LSRA MGLA MODF RBSA UUP XYLG YBHF YBIT YEJF YHES YJJK YPHE YTFR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
34_Q 212_A 4.458 1.00
12_G 25_D 4.349 1.00
265_A 274_P 4.344 1.00
262_R 278_A 4.128 1.00
24_T 220_R 3.946 1.00
264_D 312_Q 3.908 1.00
283_E 468_R 3.736 1.00
11_R 63_S 3.668 1.00
299_M 455_A 3.578 1.00
263_L 266_V 3.377 1.00
63_S 70_E 3.333 1.00
36_H 214_T 3.316 1.00
9_S 29_D 3.21 1.00
262_R 314_Y 3.202 1.00
10_F 13_I 3.192 1.00
21_K 24_T 2.963 1.00
312_Q 319_P 2.924 1.00
300_K 306_T 2.861 1.00
273_T 476_E 2.718 1.00
37_A 210_S 2.7 1.00
9_S 65_V 2.612 1.00
286_G 466_A 2.612 1.00
285_V 470_V 2.6 1.00
123_E 126_L 2.562 1.00
116_N 119_L 2.55 1.00
383_I 393_A 2.509 1.00
263_L 277_L 2.506 1.00
67_N 163_K 2.496 1.00
316_D 419_K 2.477 1.00
332_G 419_K 2.463 1.00
227_D 230_Q 2.46 1.00
14_G 25_D 2.436 1.00
50_L 199_V 2.389 1.00
265_A 276_S 2.324 1.00
268_A 301_G 2.318 1.00
187_R 208_A 2.296 1.00
268_A 309_T 2.262 1.00
121_N 138_D 2.257 1.00
139_T 143_Y 2.253 1.00
264_D 314_Y 2.245 1.00
130_H 192_E 2.243 1.00
12_G 27_S 2.222 1.00
259_E 262_R 2.214 1.00
456_S 462_V 2.211 1.00
16_T 21_K 2.206 1.00
301_G 308_I 2.096 1.00
83_G 163_K 2.089 1.00
281_S 419_K 2.074 1.00
17_F 57_Y 2.06 1.00
119_L 123_E 2.055 1.00
298_L 472_M 1.996 1.00
348_V 398_M 1.983 1.00
299_M 422_L 1.97 1.00
267_K 274_P 1.953 1.00
10_F 28_F 1.941 1.00
14_G 21_K 1.938 1.00
123_E 161_N 1.933 1.00
267_K 310_A 1.923 1.00
470_V 480_E 1.917 1.00
444_A 448_Q 1.897 1.00
136_D 139_T 1.877 1.00
10_F 53_L 1.842 1.00
258_E 281_S 1.827 1.00
279_V 285_V 1.827 1.00
73_F 82_A 1.826 1.00
31_Y 34_Q 1.825 1.00
125_G 129_K 1.798 1.00
98_T 101_E 1.782 1.00
210_S 228_M 1.781 1.00
85_A 157_A 1.765 1.00
214_T 221_Y 1.762 1.00
280_R 283_E 1.739 1.00
122_Y 126_L 1.723 1.00
454_F 465_V 1.718 1.00
75_D 78_A 1.717 1.00
264_D 276_S 1.706 1.00
103_I 159_A 1.704 1.00
382_H 415_S 1.695 1.00
286_G 462_V 1.694 1.00
186_I 196_I 1.688 1.00
96_E 142_K 1.675 1.00
11_R 65_V 1.672 1.00
277_L 470_V 1.669 1.00
381_H 385_S 1.659 1.00
14_G 61_T 1.659 1.00
303_F 422_L 1.656 1.00
30_C 164_I 1.632 1.00
32_A 163_K 1.626 1.00
279_V 451_A 1.619 1.00
35_V 186_I 1.584 1.00
140_P 143_Y 1.584 1.00
235_A 238_Q 1.582 1.00
70_E 73_F 1.574 1.00
419_K 450_V 1.573 1.00
223_K 239_A 1.57 1.00
382_H 411_G 1.557 1.00
352_R 394_E 1.555 1.00
87_I 167_F 1.541 1.00
400_L 408_A 1.539 1.00
385_S 444_A 1.539 1.00
479_G 494_L 1.538 1.00
383_I 390_T 1.536 1.00
225_F 231_V 1.53 1.00
470_V 477_I 1.522 1.00
430_I 438_I 1.508 1.00
74_S 78_A 1.504 1.00
270_G 273_T 1.501 1.00
11_R 29_D 1.501 1.00
397_I 408_A 1.499 1.00
392_G 395_Q 1.498 1.00
259_E 278_A 1.494 1.00
263_L 302_M 1.491 1.00
130_H 188_E 1.49 1.00
259_E 280_R 1.489 1.00
15_K 52_I 1.484 1.00
163_K 194_R 1.482 1.00
266_V 308_I 1.479 1.00
7_Y 195_V 1.477 1.00
12_G 61_T 1.468 1.00
371_N 374_W 1.462 1.00
346_I 357_I 1.461 1.00
127_Q 159_A 1.453 1.00
11_R 27_S 1.453 1.00
13_I 52_I 1.446 1.00
265_A 310_A 1.437 1.00
30_C 36_H 1.423 1.00
268_A 306_T 1.411 1.00
264_D 278_A 1.409 1.00
281_S 451_A 1.405 0.99
212_A 224_T 1.386 0.99
28_F 214_T 1.383 0.99
468_R 480_E 1.374 0.99
119_L 122_Y 1.372 0.99
279_V 420_V 1.371 0.99
284_I 442_I 1.368 0.99
54_S 86_I 1.365 0.99
56_N 88_Y 1.362 0.99
184_R 188_E 1.344 0.99
350_S 353_D 1.341 0.99
126_L 130_H 1.34 0.99
93_L 141_L 1.335 0.99
145_S 148_Q 1.332 0.99
263_L 313_V 1.331 0.99
15_K 48_T 1.323 0.99
180_D 208_A 1.32 0.99
272_R 275_I 1.319 0.99
349_H 353_D 1.317 0.99
190_R 211_D 1.317 0.99
66_I 164_I 1.311 0.99
380_D 393_A 1.31 0.99
200_S 206_I 1.31 0.99
188_E 192_E 1.309 0.99
492_L 495_A 1.309 0.99
486_A 490_Q 1.302 0.99
336_C 423_L 1.302 0.99
378_N 381_H 1.286 0.99
50_L 166_A 1.277 0.99
356_N 375_E 1.267 0.99
8_L 66_I 1.264 0.99
351_V 408_A 1.262 0.99
442_I 452_V 1.259 0.99
352_R 393_A 1.257 0.99
380_D 384_R 1.248 0.99
207_F 229_Q 1.24 0.98
395_Q 399_N 1.237 0.98
283_E 467_D 1.236 0.98
315_I 320_I 1.225 0.98
396_L 399_N 1.213 0.98
188_E 191_K 1.21 0.98
266_V 301_G 1.209 0.98
104_Y 124_A 1.203 0.98
65_V 70_E 1.203 0.98
377_N 381_H 1.201 0.98
483_H 486_A 1.2 0.98
16_T 61_T 1.2 0.98
187_R 190_R 1.196 0.98
50_L 86_I 1.187 0.98
333_M 420_V 1.186 0.98
52_I 64_V 1.183 0.98
6_P 31_Y 1.181 0.98
354_N 412_R 1.17 0.97
423_L 442_I 1.168 0.97
315_I 420_V 1.164 0.97
180_D 184_R 1.153 0.97
481_L 494_L 1.15 0.97
346_I 349_H 1.149 0.97
125_G 137_P 1.144 0.97
482_L 485_Q 1.142 0.97
131_L 155_A 1.137 0.97
100_A 124_A 1.134 0.97
17_F 48_T 1.129 0.97
376_E 380_D 1.128 0.97
100_A 121_N 1.127 0.97
34_Q 211_D 1.125 0.97
267_K 273_T 1.119 0.96
14_G 24_T 1.116 0.96
274_P 476_E 1.115 0.96
149_W 339_D 1.113 0.96
232_D 235_A 1.113 0.96
52_I 59_P 1.112 0.96
15_K 57_Y 1.111 0.96
128_L 137_P 1.109 0.96
259_E 281_S 1.108 0.96
487_D 490_Q 1.107 0.96
94_V 105_L 1.104 0.96
66_I 84_V 1.103 0.96
23_L 26_I 1.097 0.96
285_V 453_L 1.092 0.96
301_G 313_V 1.09 0.96
85_A 162_A 1.09 0.96
104_Y 120_L 1.089 0.96
144_L 152_V 1.082 0.96
374_W 377_N 1.08 0.95
345_I 397_I 1.079 0.95
334_M 418_M 1.077 0.95
25_D 220_R 1.077 0.95
272_R 301_G 1.077 0.95
210_S 213_I 1.076 0.95
78_A 81_N 1.073 0.95
13_I 59_P 1.073 0.95
121_N 125_G 1.073 0.95
17_F 22_A 1.069 0.95
277_L 298_L 1.069 0.95
287_L 470_V 1.068 0.95
95_P 149_W 1.065 0.95
32_A 195_V 1.063 0.95
259_E 314_Y 1.051 0.94
129_K 134_D 1.048 0.94
87_I 157_A 1.043 0.94
47_S 51_K 1.042 0.94
141_L 152_V 1.036 0.94
16_T 60_T 1.033 0.94
10_F 64_V 1.033 0.94
260_R 316_D 1.033 0.94
469_I 486_A 1.031 0.94
260_R 451_A 1.031 0.94
69_Q 78_A 1.03 0.94
8_L 53_L 1.029 0.94
37_A 206_I 1.027 0.94
383_I 388_I 1.008 0.93
183_F 208_A 1.007 0.93
445_L 450_V 1.007 0.93
314_Y 319_P 1.006 0.93
15_K 60_T 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4finA20.91071000.215Contact Map0.756
3g5uA20.96631000.235Contact Map0.645
4f4cA10.96631000.237Contact Map0.711
1yqtA10.92261000.282Contact Map0.65
2iw3A20.8751000.288Contact Map0.728
3bk7A10.92261000.293Contact Map0.626
3ozxA20.90281000.295Contact Map0.669
3j16B10.92061000.31Contact Map0.479
3ux8A10.94641000.311Contact Map0.584
2vf7A30.96631000.42Contact Map0.561

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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