GREMLIN.BAKERLAB.org
Powered by OPENSEQ.org
ARTP - Arginine transport ATP-binding protein ArtP
UniProt: P0AAF6 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11624
Length: 242 (238)
Sequences: 70625
Seq/Len: 296.74

ARTP
Paralog alert: 0.94 [within 20: 0.85] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
32_V 208_A 3.338 1.00
134_Y 137_R 3.133 1.00
29_E 210_R 3.064 1.00
4_Q 24_D 3.039 1.00
6_N 58_T 2.895 1.00
58_T 65_H 2.836 1.00
7_G 20_D 2.833 1.00
31_L 212_V 2.741 1.00
83_N 161_Q 2.738 1.00
16_Q 19_F 2.697 1.00
4_Q 60_N 2.614 1.00
127_E 132_K 2.509 1.00
19_F 218_H 2.47 1.00
26_P 29_E 2.417 1.00
210_R 222_Q 2.346 1.00
121_R 159_E 2.273 1.00
223_G 227_C 2.223 1.00
9_N 20_D 2.223 1.00
11_F 16_Q 2.219 1.00
5_L 8_I 2.217 1.00
10_C 47_V 2.212 1.00
62_A 161_Q 2.16 1.00
99_V 142_L 2.108 1.00
9_N 16_Q 2.092 1.00
123_E 135_S 2.046 1.00
126_L 135_S 2.045 1.00
9_N 56_S 2.002 1.00
224_D 227_C 1.995 1.00
212_V 219_I 1.94 1.00
100_Q 136_D 1.921 1.00
6_N 60_N 1.847 1.00
27_Q 161_Q 1.811 1.00
100_Q 135_S 1.788 1.00
100_Q 123_E 1.754 1.00
29_E 209_S 1.744 1.00
7_G 22_T 1.738 1.00
12_Y 17_A 1.721 1.00
159_E 192_I 1.709 1.00
10_C 55_R 1.696 1.00
128_R 186_E 1.696 1.00
212_V 222_Q 1.685 1.00
186_E 190_T 1.654 1.00
100_Q 122_A 1.589 1.00
121_R 124_K 1.589 1.00
114_S 117_Q 1.586 1.00
89_Q 144_G 1.582 1.00
128_R 190_T 1.579 1.00
124_K 128_R 1.55 1.00
119_L 123_E 1.519 1.00
137_R 141_H 1.502 1.00
100_Q 104_I 1.496 1.00
188_A 209_S 1.487 1.00
10_C 52_E 1.448 1.00
60_N 65_H 1.44 1.00
198_T 204_A 1.424 1.00
45_L 197_V 1.407 0.99
18_L 47_V 1.404 0.99
11_F 55_R 1.4 0.99
6_N 24_D 1.387 0.99
223_G 228_F 1.368 0.99
132_K 135_S 1.344 0.99
47_V 54_P 1.341 0.99
120_A 124_K 1.338 0.99
62_A 83_N 1.333 0.99
100_Q 119_L 1.329 0.99
23_L 212_V 1.328 0.99
25_C 31_L 1.317 0.99
5_L 48_L 1.312 0.99
31_L 222_Q 1.291 0.99
165_F 184_I 1.269 0.99
9_N 19_F 1.253 0.99
104_I 118_A 1.25 0.99
104_I 122_A 1.234 0.98
30_T 188_A 1.231 0.98
5_L 23_L 1.228 0.98
2_S 62_A 1.227 0.98
103_L 157_M 1.225 0.98
123_E 127_E 1.208 0.98
99_V 150_V 1.207 0.98
8_I 54_P 1.205 0.98
185_R 188_A 1.199 0.98
121_R 125_L 1.195 0.98
6_N 22_T 1.193 0.98
134_Y 146_Q 1.188 0.98
98_T 101_Q 1.187 0.98
12_Y 43_S 1.183 0.98
102_N 154_R 1.167 0.97
125_L 157_M 1.163 0.97
45_L 164_L 1.161 0.97
165_F 194_Q 1.15 0.97
73_S 76_A 1.148 0.97
220_V 233_T 1.145 0.97
177_T 203_V 1.143 0.97
188_A 194_Q 1.141 0.97
30_T 194_Q 1.14 0.97
48_L 195_V 1.133 0.97
26_P 210_R 1.128 0.97
46_R 52_E 1.128 0.97
233_T 236_F 1.115 0.96
5_L 44_L 1.113 0.96
47_V 59_L 1.109 0.96
129_L 153_A 1.103 0.96
183_I 186_E 1.101 0.96
123_E 132_K 1.101 0.96
44_L 214_M 1.081 0.95
27_Q 62_A 1.077 0.95
181_V 203_V 1.075 0.95
142_L 150_V 1.075 0.95
21_I 44_L 1.073 0.95
49_N 86_M 1.072 0.95
87_V 152_I 1.069 0.95
161_Q 192_I 1.064 0.95
104_I 119_L 1.049 0.94
163_L 194_Q 1.043 0.94
49_N 164_L 1.04 0.94
87_V 165_F 1.03 0.94
187_L 192_I 1.029 0.94
138_Y 141_H 1.022 0.93
117_Q 120_A 1.013 0.93
101_Q 104_I 1.012 0.93
124_K 127_E 1.009 0.93
130_R 179_Q 1.004 0.93
31_L 210_R 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2it1A20.9628100-0.049Contact Map0.876
3tuiC40.9835100-0.048Contact Map0.885
1v43A10.9628100-0.048Contact Map0.824
2yyzA10.9628100-0.045Contact Map0.818
1oxxK10.9835100-0.045Contact Map0.807
1g29120.9835100-0.044Contact Map0.9
3rlfA20.9628100-0.04Contact Map0.846
1z47A20.9628100-0.039Contact Map0.834
3fvqA20.9793100-0.037Contact Map0.782
2oljA20.9835100-0.022Contact Map0.89

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0309 seconds.