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GLTL - Glutamate/aspartate transport ATP-binding protein GltL
UniProt: P0AAG3 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12663
Length: 241 (238)
Sequences: 70809
Seq/Len: 297.52

GLTL
Paralog alert: 0.94 [within 20: 0.86] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
31_V 203_A 3.322 1.00
3_T 23_E 3.127 1.00
28_E 205_R 3.07 1.00
129_H 132_K 3.025 1.00
57_E 64_V 2.946 1.00
5_K 57_E 2.944 1.00
6_N 19_D 2.909 1.00
78_R 156_I 2.808 1.00
30_V 207_I 2.703 1.00
15_Q 18_T 2.661 1.00
3_T 59_T 2.611 1.00
122_E 127_S 2.586 1.00
18_T 213_K 2.516 1.00
25_K 28_E 2.435 1.00
205_R 217_D 2.326 1.00
8_S 19_D 2.302 1.00
4_L 7_V 2.296 1.00
116_K 154_D 2.248 1.00
218_S 222_A 2.22 1.00
10_W 15_Q 2.195 1.00
9_K 46_T 2.193 1.00
61_D 156_I 2.154 1.00
94_I 137_L 2.097 1.00
8_S 15_Q 2.096 1.00
118_L 130_A 2.033 1.00
121_L 130_A 2.022 1.00
219_P 222_A 2.009 1.00
95_I 131_N 1.987 1.00
8_S 55_Q 1.976 1.00
207_I 214_I 1.96 1.00
26_K 156_I 1.858 1.00
95_I 130_A 1.843 1.00
5_K 59_T 1.832 1.00
6_N 21_S 1.806 1.00
95_I 118_L 1.765 1.00
28_E 204_N 1.762 1.00
181_E 185_E 1.754 1.00
154_D 187_M 1.727 1.00
123_R 181_E 1.712 1.00
11_Y 16_V 1.697 1.00
95_I 117_A 1.668 1.00
9_K 54_Q 1.662 1.00
207_I 217_D 1.648 1.00
123_R 185_E 1.607 1.00
109_D 112_P 1.573 1.00
116_K 119_K 1.567 1.00
119_K 123_R 1.548 1.00
114_R 118_L 1.511 1.00
84_Q 139_G 1.496 1.00
132_K 136_Q 1.489 1.00
183_A 204_N 1.476 1.00
59_T 64_V 1.434 1.00
17_L 46_T 1.432 1.00
44_I 192_V 1.42 1.00
218_S 223_F 1.42 1.00
9_K 51_E 1.413 1.00
5_K 23_E 1.412 1.00
95_I 114_R 1.41 1.00
99_T 117_A 1.403 0.99
10_W 54_Q 1.401 0.99
193_T 199_A 1.39 0.99
99_T 113_A 1.389 0.99
95_I 99_T 1.386 0.99
115_E 119_K 1.38 0.99
61_D 78_R 1.369 0.99
24_V 30_V 1.368 0.99
4_L 47_V 1.351 0.99
46_T 53_V 1.343 0.99
22_T 207_I 1.339 0.99
98_L 152_C 1.297 0.99
8_S 18_T 1.294 0.99
160_F 179_M 1.269 0.99
30_V 217_D 1.257 0.99
4_L 22_T 1.25 0.99
97_N 149_R 1.248 0.99
127_S 130_A 1.24 0.98
93_S 96_E 1.224 0.98
5_K 21_S 1.206 0.98
120_L 152_C 1.202 0.98
29_V 183_A 1.197 0.98
118_L 122_E 1.194 0.98
116_K 120_L 1.192 0.98
129_H 141_Q 1.186 0.98
7_V 53_V 1.184 0.98
94_I 145_V 1.184 0.98
180_V 183_A 1.172 0.98
29_V 189_M 1.171 0.98
11_Y 42_T 1.171 0.98
46_T 58_I 1.166 0.97
183_A 189_M 1.148 0.97
44_I 159_L 1.146 0.97
47_V 190_M 1.144 0.97
25_K 205_R 1.124 0.97
229_S 232_A 1.122 0.97
45_K 51_E 1.12 0.96
1_M 61_D 1.11 0.96
43_L 209_M 1.106 0.96
118_L 127_S 1.101 0.96
178_V 181_E 1.1 0.96
172_I 198_F 1.094 0.96
4_L 43_L 1.094 0.96
124_V 148_A 1.085 0.96
137_L 145_V 1.082 0.96
99_T 114_R 1.082 0.96
82_V 147_I 1.076 0.95
160_F 189_M 1.065 0.95
156_I 187_M 1.063 0.95
20_C 43_L 1.057 0.95
26_K 61_D 1.057 0.95
215_V 229_S 1.048 0.94
112_P 115_E 1.046 0.94
9_K 42_T 1.04 0.94
48_N 81_M 1.04 0.94
30_V 205_R 1.037 0.94
182_L 187_M 1.036 0.94
96_E 99_T 1.035 0.94
176_L 198_F 1.029 0.94
82_V 160_F 1.026 0.94
133_F 136_Q 1.02 0.93
6_N 55_Q 1.02 0.93
158_M 189_M 1.015 0.93
119_K 122_E 1.015 0.93
93_S 133_F 1.015 0.93
10_W 16_V 1.008 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiC40.9959100-0.053Contact Map0.882
2it1A20.9793100-0.052Contact Map0.871
1v43A10.9793100-0.049Contact Map0.826
2yyzA10.9793100-0.049Contact Map0.814
1g29120.9959100-0.049Contact Map0.895
1oxxK10.9959100-0.047Contact Map0.804
3fvqA20.9959100-0.043Contact Map0.78
1z47A20.9793100-0.042Contact Map0.835
3rlfA20.9793100-0.041Contact Map0.833
2oljA20.9959100-0.029Contact Map0.887

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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