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MDLB - Multidrug resistance-like ATP-binding protein MdlB
UniProt: P0AAG5 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14374
Length: 593 (569)
Sequences: 22304
Seq/Len: 39.20

MDLB
Paralog alert: 0.94 [within 20: 0.61] - ratio of genomes with paralogs
Cluster includes: CYDC CYDD MDLA MDLB MSBA YDDA YOJI
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
456_A 466_I 5.187 1.00
345_N 359_N 5.152 1.00
368_N 543_T 4.819 1.00
342_E 363_S 4.684 1.00
365_P 368_N 4.616 1.00
558_H 568_Y 4.444 1.00
344_D 397_E 4.418 1.00
429_D 433_A 4.203 1.00
432_L 443_E 4.078 1.00
543_T 555_Q 3.993 1.00
451_E 456_A 3.877 1.00
344_D 399_R 3.807 1.00
456_A 460_R 3.622 1.00
358_K 551_Q 3.508 1.00
397_E 404_P 3.502 1.00
340_T 363_S 3.476 1.00
442_S 445_R 3.448 1.00
347_S 359_N 3.335 1.00
432_L 467_Y 3.298 1.00
450_L 466_I 3.236 1.00
343_V 346_V 3.103 1.00
565_Q 569_W 3.04 1.00
432_L 436_T 3.024 1.00
384_A 531_I 3.019 1.00
443_E 447_W 2.944 1.00
569_W 573_Q 2.913 1.00
435_V 450_L 2.849 1.00
439_R 445_R 2.75 1.00
418_A 495_P 2.728 1.00
384_A 499_I 2.721 1.00
448_Q 452_T 2.712 1.00
557_T 560_Q 2.674 1.00
389_G 392_P 2.67 1.00
432_L 446_V 2.648 1.00
342_E 399_R 2.634 1.00
364_V 370_V 2.599 1.00
447_W 451_E 2.561 1.00
362_L 545_L 2.537 1.00
554_E 566_G 2.501 1.00
340_T 365_P 2.478 1.00
416_G 496_Q 2.474 1.00
435_V 446_V 2.451 1.00
447_W 456_A 2.427 1.00
464_D 468_T 2.375 1.00
409_S 412_A 2.373 1.00
554_E 565_Q 2.348 1.00
494_T 526_T 2.344 1.00
340_T 366_S 2.338 1.00
347_S 395_E 2.331 1.00
355_L 358_K 2.319 1.00
545_L 555_Q 2.299 1.00
455_L 458_L 2.282 1.00
13_R 323_D 2.268 1.00
158_V 162_S 2.23 1.00
556_G 560_Q 2.184 1.00
343_V 362_L 2.18 1.00
392_P 406_S 2.158 1.00
554_E 564_A 2.15 1.00
369_F 541_A 2.146 1.00
447_W 460_R 2.08 1.00
448_Q 451_E 2.062 1.00
520_A 540_D 2.046 1.00
17_Y 103_D 2.04 1.00
436_T 446_V 2.036 1.00
345_N 361_N 2.015 1.00
548_H 567_R 2.003 1.00
51_D 280_E 1.995 1.00
51_D 282_G 1.985 1.00
347_S 355_L 1.978 1.00
370_V 543_T 1.973 1.00
450_L 459_A 1.941 1.00
349_A 394_T 1.936 1.00
349_A 355_L 1.933 1.00
364_V 529_V 1.93 1.00
449_A 453_V 1.871 1.00
341_I 529_V 1.858 1.00
444_E 447_W 1.843 1.00
445_R 494_T 1.838 1.00
436_T 443_E 1.838 1.00
357_L 360_I 1.83 1.00
404_P 407_S 1.81 1.00
553_V 567_R 1.81 1.00
545_L 552_A 1.779 1.00
339_G 401_D 1.771 1.00
372_L 383_L 1.762 1.00
222_Q 225_R 1.751 1.00
21_W 99_Q 1.734 1.00
512_E 534_R 1.693 1.00
131_D 317_R 1.678 1.00
447_W 466_I 1.668 1.00
164_D 274_S 1.659 1.00
319_F 323_D 1.655 1.00
532_A 537_T 1.654 1.00
370_V 545_L 1.652 1.00
445_R 448_Q 1.648 1.00
383_L 547_L 1.646 1.00
554_E 569_W 1.639 1.00
19_S 22_R 1.623 1.00
539_V 559_Q 1.622 1.00
359_N 551_Q 1.61 1.00
454_Q 514_A 1.599 1.00
471_G 476_N 1.598 1.00
452_T 521_A 1.597 1.00
369_F 530_V 1.588 1.00
548_H 553_V 1.586 1.00
443_E 467_Y 1.583 1.00
372_L 545_L 1.581 1.00
457_E 460_R 1.576 1.00
69_A 73_G 1.562 1.00
107_A 111_Q 1.548 1.00
368_N 542_D 1.533 1.00
441_I 492_V 1.529 1.00
348_F 382_T 1.521 1.00
562_L 572_Y 1.511 1.00
388_M 419_M 1.507 1.00
273_F 277_G 1.504 1.00
199_Y 236_S 1.499 1.00
431_F 485_L 1.497 1.00
393_L 405_L 1.487 1.00
450_L 456_A 1.481 1.00
507_I 515_I 1.471 1.00
513_Q 517_H 1.471 1.00
340_T 401_D 1.47 1.00
521_A 524_E 1.466 1.00
371_A 541_A 1.461 1.00
464_D 469_P 1.456 1.00
330_G 409_S 1.444 1.00
435_V 492_V 1.43 1.00
470_L 477_L 1.426 1.00
194_R 316_E 1.401 0.99
443_E 446_V 1.382 0.99
376_T 511_T 1.382 0.99
365_P 543_T 1.375 0.99
269_M 273_F 1.366 0.99
348_F 391_Y 1.363 0.99
398_I 405_L 1.361 0.99
360_I 383_L 1.357 0.99
338_S 401_D 1.349 0.99
459_A 466_I 1.349 0.99
517_H 521_A 1.348 0.99
567_R 570_Q 1.348 0.99
362_L 383_L 1.34 0.99
226_F 437_L 1.339 0.99
436_T 441_I 1.337 0.99
418_A 490_V 1.336 0.99
346_V 393_L 1.334 0.99
47_S 286_A 1.331 0.99
202_D 236_S 1.33 0.99
188_Y 191_P 1.327 0.99
455_L 459_A 1.325 0.99
400_L 497_I 1.324 0.99
428_A 469_P 1.322 0.99
161_F 168_A 1.317 0.99
375_H 567_R 1.316 0.99
462_M 468_T 1.309 0.99
117_D 391_Y 1.303 0.99
180_V 184_I 1.302 0.99
544_I 558_H 1.3 0.99
560_Q 564_A 1.298 0.99
107_A 326_R 1.296 0.99
452_T 491_L 1.294 0.99
479_V 484_L 1.293 0.99
449_A 491_L 1.29 0.99
375_H 548_H 1.29 0.99
532_A 538_I 1.284 0.99
386_L 398_I 1.278 0.99
228_E 232_E 1.277 0.99
213_G 425_V 1.275 0.99
161_F 165_W 1.259 0.99
559_Q 563_A 1.256 0.99
458_L 481_Q 1.248 0.99
445_R 492_V 1.241 0.98
167_M 287_F 1.24 0.98
441_I 445_R 1.238 0.98
166_R 278_T 1.237 0.98
165_W 169_L 1.23 0.98
360_I 552_A 1.228 0.98
442_S 492_V 1.224 0.98
43_P 290_Y 1.224 0.98
348_F 386_L 1.223 0.98
523_R 528_L 1.222 0.98
371_A 538_I 1.221 0.98
65_A 69_A 1.22 0.98
218_Q 223_Q 1.219 0.98
344_D 361_N 1.214 0.98
342_E 402_G 1.207 0.98
345_N 395_E 1.205 0.98
450_L 455_L 1.2 0.98
460_R 465_G 1.2 0.98
444_E 448_Q 1.197 0.98
134_V 314_A 1.195 0.98
206_G 233_A 1.192 0.98
104_V 321_L 1.187 0.98
343_V 387_L 1.184 0.98
403_R 408_L 1.181 0.98
224_A 228_E 1.18 0.98
347_S 358_K 1.178 0.98
331_N 407_S 1.168 0.97
230_M 234_S 1.165 0.97
403_R 407_S 1.163 0.97
107_A 322_M 1.158 0.97
387_L 529_V 1.157 0.97
34_V 81_L 1.153 0.97
199_Y 202_D 1.15 0.97
547_L 552_A 1.144 0.97
47_S 51_D 1.129 0.97
447_W 450_L 1.128 0.97
341_I 400_L 1.127 0.97
454_Q 511_T 1.126 0.97
331_N 334_R 1.126 0.97
420_V 490_V 1.126 0.97
20_P 99_Q 1.122 0.97
461_S 481_Q 1.117 0.96
393_L 398_I 1.117 0.96
364_V 527_T 1.117 0.96
410_H 414_R 1.114 0.96
458_L 462_M 1.112 0.96
210_I 226_F 1.112 0.96
120_P 123_Q 1.109 0.96
464_D 467_Y 1.108 0.96
369_F 528_L 1.107 0.96
160_M 287_F 1.099 0.96
435_V 485_L 1.098 0.96
432_L 466_I 1.097 0.96
280_E 283_V 1.096 0.96
460_R 466_I 1.096 0.96
558_H 562_L 1.089 0.96
477_L 485_L 1.089 0.96
117_D 385_S 1.087 0.96
471_G 474_G 1.086 0.96
343_V 383_L 1.086 0.96
199_Y 240_A 1.08 0.95
342_E 361_N 1.079 0.95
430_T 433_A 1.079 0.95
66_G 70_A 1.074 0.95
31_M 84_A 1.07 0.95
226_F 229_R 1.07 0.95
376_T 484_L 1.069 0.95
110_R 326_R 1.062 0.95
274_S 278_T 1.06 0.95
455_L 461_S 1.058 0.95
449_A 492_V 1.056 0.95
13_R 319_F 1.055 0.95
123_Q 201_A 1.051 0.94
270_L 274_S 1.049 0.94
119_Q 123_Q 1.048 0.94
31_M 81_L 1.046 0.94
346_V 386_L 1.044 0.94
448_Q 494_T 1.041 0.94
340_T 402_G 1.04 0.94
370_V 529_V 1.031 0.94
487_L 500_L 1.025 0.93
388_M 499_I 1.021 0.93
400_L 413_L 1.02 0.93
330_G 410_H 1.014 0.93
454_Q 517_H 1.013 0.93
102_T 106_D 1.008 0.93
107_A 110_R 1.007 0.93
366_S 496_Q 1.005 0.93
127_R 320_E 1.002 0.92
457_E 461_S 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qf4B10.97641000.145Contact Map0.727
3b60A40.9681000.149Contact Map0.746
3b5xA20.9681000.151Contact Map0.102
4a82A40.95451000.153Contact Map0.076
4f4cA10.99661000.154Contact Map0.726
2yl4A10.97981000.165Contact Map0.719
3qf4A10.96631000.167Contact Map0.747
3g5uA20.99661000.172Contact Map0.673
3nh6A10.50931000.434Contact Map0.782
3vx4A20.45191000.497Contact Map0.84

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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