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MGLA - Galactose/methyl galactoside import ATP-binding protein MglA
UniProt: P0AAG8 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10592
Length: 506 (492)
Sequences: 13979
Seq/Len: 28.41

MGLA
Paralog alert: 0.93 [within 20: 0.27] - ratio of genomes with paralogs
Cluster includes: ALSA ARAG GSIA LSRA MGLA MODF RBSA UUP XYLG YBHF YBIT YEJF YHES YJJK YPHE YTFR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
40_S 218_E 4.506 1.00
18_G 31_N 4.398 1.00
270_N 281_D 4.378 1.00
267_E 285_D 4.182 1.00
30_D 226_Q 3.972 1.00
269_R 319_T 3.928 1.00
290_E 475_R 3.708 1.00
17_S 69_T 3.688 1.00
306_V 462_I 3.479 1.00
69_T 76_E 3.391 1.00
42_H 220_T 3.36 1.00
15_E 35_K 3.332 1.00
268_V 271_L 3.315 1.00
267_E 321_T 3.168 1.00
16_M 19_I 3.157 1.00
319_T 326_Q 3.025 1.00
27_K 30_D 2.967 1.00
307_E 313_R 2.863 1.00
280_R 483_L 2.773 1.00
292_L 477_L 2.734 1.00
15_E 71_L 2.635 1.00
122_D 125_K 2.572 1.00
20_N 31_N 2.548 1.00
43_A 216_C 2.538 1.00
390_I 400_H 2.537 1.00
293_G 473_T 2.526 1.00
339_G 426_E 2.517 1.00
129_E 132_A 2.5 1.00
232_P 235_G 2.493 1.00
323_H 426_E 2.489 1.00
73_Q 169_K 2.488 1.00
268_V 284_F 2.45 1.00
193_R 214_Q 2.339 1.00
127_Y 144_R 2.337 1.00
270_N 283_S 2.3 1.00
145_A 149_T 2.279 1.00
269_R 321_T 2.279 1.00
273_S 308_T 2.269 1.00
56_L 205_I 2.255 1.00
22_S 27_K 2.244 1.00
136_E 198_R 2.219 1.00
18_G 33_N 2.214 1.00
264_V 267_E 2.198 1.00
273_S 316_S 2.155 1.00
463_S 469_L 2.115 1.00
288_K 426_E 2.113 1.00
23_F 63_Y 2.058 1.00
125_K 129_E 2.053 1.00
308_T 315_K 2.046 1.00
272_T 281_D 2.026 1.00
89_G 169_K 2.017 1.00
305_I 479_M 1.995 1.00
451_E 455_K 1.992 1.00
477_L 487_I 1.969 1.00
355_Y 405_G 1.958 1.00
129_E 167_N 1.952 1.00
20_N 27_K 1.949 1.00
306_V 429_M 1.937 1.00
272_T 317_A 1.93 1.00
37_R 40_S 1.903 1.00
220_T 227_W 1.835 1.00
79_F 88_N 1.831 1.00
16_M 34_L 1.828 1.00
263_E 288_K 1.825 1.00
216_C 233_L 1.805 1.00
104_S 107_D 1.787 1.00
286_L 292_L 1.782 1.00
287_H 290_E 1.782 1.00
16_M 59_L 1.779 1.00
461_I 472_I 1.758 1.00
81_S 84_E 1.747 1.00
17_S 71_L 1.741 1.00
128_R 132_A 1.737 1.00
102_Q 148_G 1.718 1.00
131_K 135_D 1.717 1.00
109_M 165_S 1.714 1.00
388_W 392_S 1.711 1.00
277_P 280_R 1.711 1.00
293_G 469_L 1.689 1.00
269_R 283_S 1.689 1.00
192_I 202_I 1.683 1.00
91_S 163_A 1.682 1.00
284_F 477_L 1.666 1.00
38_P 169_K 1.664 1.00
142_D 145_A 1.651 1.00
389_V 422_L 1.645 1.00
20_N 67_S 1.622 1.00
286_L 458_G 1.612 1.00
426_E 457_K 1.608 1.00
359_G 401_R 1.607 1.00
76_E 79_F 1.595 1.00
310_F 429_M 1.587 1.00
392_S 451_E 1.574 1.00
489_D 492_T 1.569 1.00
36_V 170_I 1.561 1.00
146_R 149_T 1.553 1.00
389_V 418_G 1.548 1.00
41_I 192_I 1.545 1.00
231_E 236_L 1.542 1.00
93_V 173_M 1.539 1.00
229_A 244_M 1.529 1.00
18_G 67_S 1.528 1.00
213_F 234_A 1.522 1.00
390_I 397_T 1.515 1.00
270_N 317_A 1.51 1.00
169_K 200_C 1.51 1.00
264_V 285_D 1.496 1.00
407_L 415_V 1.494 1.00
80_H 84_E 1.493 1.00
13_L 201_G 1.489 1.00
218_E 230_T 1.489 1.00
477_L 484_V 1.487 1.00
437_I 445_I 1.486 1.00
486_G 501_L 1.48 1.00
136_E 194_K 1.48 1.00
404_I 415_V 1.471 1.00
399_G 402_T 1.463 1.00
268_V 309_L 1.462 1.00
264_V 287_H 1.456 1.00
17_S 35_K 1.448 1.00
17_S 33_N 1.448 1.00
271_L 315_K 1.444 1.00
21_K 58_C 1.443 1.00
353_Y 364_I 1.44 1.00
133_I 165_S 1.431 1.00
378_D 381_R 1.428 1.00
269_R 285_D 1.417 1.00
288_K 458_G 1.414 1.00
356_L 360_F 1.412 1.00
274_L 316_S 1.408 1.00
125_K 128_R 1.383 0.99
36_V 42_H 1.376 0.99
19_I 58_C 1.372 0.99
387_Q 400_H 1.368 0.99
34_L 220_T 1.366 0.99
60_F 92_M 1.363 0.99
357_D 360_F 1.362 0.99
499_L 502_A 1.351 0.99
343_V 430_L 1.346 0.99
240_K 243_A 1.341 0.99
99_L 147_V 1.341 0.99
151_S 154_Q 1.336 0.99
194_K 198_R 1.333 0.99
286_L 427_I 1.33 0.99
186_N 214_Q 1.32 0.99
196_K 217_D 1.316 0.99
385_D 388_W 1.312 0.99
279_I 282_V 1.31 0.99
268_V 320_I 1.309 0.99
475_R 487_I 1.309 0.99
190_T 194_K 1.307 0.99
21_K 54_T 1.297 0.99
291_I 449_I 1.296 0.99
72_F 170_I 1.287 0.99
62_I 94_H 1.272 0.99
206_S 212_I 1.271 0.99
132_A 136_E 1.266 0.99
194_K 197_E 1.262 0.99
273_S 313_R 1.261 0.99
14_L 72_F 1.261 0.99
363_L 382_M 1.253 0.99
290_E 474_D 1.251 0.99
493_T 497_E 1.243 0.98
387_Q 391_D 1.241 0.98
358_I 415_V 1.233 0.98
359_G 400_H 1.23 0.98
402_T 406_S 1.223 0.98
193_R 196_K 1.217 0.98
110_W 130_T 1.217 0.98
12_Y 37_R 1.192 0.98
71_L 76_E 1.189 0.98
322_L 427_I 1.188 0.98
322_L 327_I 1.179 0.98
127_Y 131_K 1.178 0.98
403_Q 406_S 1.176 0.98
237_T 240_K 1.174 0.98
58_C 70_I 1.167 0.97
384_S 388_W 1.163 0.97
22_S 67_S 1.16 0.97
449_I 459_I 1.158 0.97
271_L 308_T 1.157 0.97
340_F 427_I 1.15 0.97
430_L 449_I 1.15 0.97
490_T 493_T 1.149 0.97
110_W 126_M 1.146 0.97
488_V 501_L 1.145 0.97
56_L 172_I 1.141 0.97
40_S 217_D 1.135 0.97
264_V 288_K 1.134 0.97
31_N 226_Q 1.134 0.97
131_K 143_P 1.125 0.97
134_F 143_P 1.122 0.97
281_D 483_L 1.122 0.97
292_L 460_I 1.12 0.96
23_F 54_T 1.119 0.96
58_C 65_K 1.118 0.96
106_M 130_T 1.117 0.96
56_L 92_M 1.116 0.96
106_M 127_Y 1.113 0.96
20_N 30_D 1.11 0.96
231_E 235_G 1.105 0.96
294_I 477_L 1.102 0.96
361_N 419_R 1.1 0.96
186_N 190_T 1.098 0.96
352_I 404_I 1.098 0.96
16_M 70_I 1.095 0.96
100_V 111_L 1.092 0.96
216_C 219_V 1.092 0.96
274_L 277_P 1.086 0.96
72_F 90_I 1.085 0.96
381_R 384_S 1.082 0.96
383_K 387_Q 1.078 0.95
353_Y 356_L 1.078 0.95
29_L 32_V 1.078 0.95
14_L 59_L 1.076 0.95
341_A 425_P 1.074 0.95
137_L 161_A 1.072 0.95
272_T 280_R 1.067 0.95
91_S 168_A 1.066 0.95
264_V 321_T 1.064 0.95
321_T 326_Q 1.063 0.95
19_I 65_K 1.063 0.95
265_I 458_G 1.062 0.95
101_L 155_M 1.062 0.95
284_F 305_I 1.061 0.95
75_K 84_E 1.06 0.95
155_M 346_E 1.06 0.95
195_L 200_C 1.06 0.95
84_E 87_E 1.049 0.94
494_T 497_E 1.049 0.94
150_L 158_I 1.045 0.94
38_P 201_G 1.044 0.94
167_N 198_R 1.031 0.94
21_K 63_Y 1.028 0.94
265_I 323_H 1.027 0.94
279_I 308_T 1.026 0.94
23_F 28_A 1.024 0.93
43_A 212_I 1.022 0.93
53_S 57_K 1.02 0.93
132_A 135_D 1.016 0.93
135_D 140_D 1.008 0.93
147_V 158_I 1.007 0.93
42_H 230_T 1.004 0.93
295_A 469_L 1.003 0.93
240_K 244_M 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4finA20.90321000.23Contact Map0.754
3g5uA20.96441000.246Contact Map0.65
4f4cA10.96251000.251Contact Map0.709
1yqtA10.92491000.287Contact Map0.641
2iw3A20.88931000.299Contact Map0.72
3bk7A10.92291000.3Contact Map0.62
3ozxA20.89331000.302Contact Map0.674
3ux8A10.94661000.317Contact Map0.589
3j16B10.92291000.317Contact Map0.471
2vf7A30.96841000.414Contact Map0.558

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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